Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Use of stem"”.
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Engineered, perfusable, human microvascular networks on a microfluidic chip
… microvascular networks on-demand using state of the art microfluidics technology. We have demonstrated the utility of this platform for studying cancer metastasis and as a test bed for drug discovery and analysis. In parallel, this platform enabled us to study, in a highly controlled …
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ENDOTHELIAL- EPITHELIAL INTERACTIONS Blood vessels friends or foes?
Diabetes affects enormous amounts of patients. In type 1 diabetes the insulin producing β cells in the islet of Langerhans are destroyed by the immune system. The β cells, which are located in the pancreas, regulate blood glucose levels. The lack of insulin production requires administration of …
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The Role of Cell Communication and 3D Cell-Matrix Environment in a Stem Cell-Based Tissue Engineering Strategy for Bone Repair
The use of stem cells for the repair of bone and cartilage is a primary research interest in modern tissue engineering strategies. The goal of this doctoral thesis was to investigate the role of cell communication and mechanical stimulation in a 3D tissue engineered construct, and to determine …
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Microgravity Exerts an Age-Dependent Effect on Cardiovascular Progenitor Cell Development
<p>The heart and its cellular components are profoundly altered by missions to space and injury on Earth. Increasing evidence has identified that one such alteration induced by spaceflight is the promotion of the efficacious use of stem cells in therapies on Earth. For this reason, neonatal and …
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In vivo bone formation using Adipose Derived Stromal Stem Cells. The histomorphometry of the ovine defect model
The use of stem cells to augment the healing of bone defects represents an exciting new frontier in many surgical disciplines. This thesis verified the in vitro osteogenic capability of ovine Adipose Derived Stromal Stem Cells (ADSCs) and Bone Marrow Derived Stem Cells (BMSCs), examined the in vivo …
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Identification of dopamine neuron progenitors in the embryonic midbrain and stem cell cultures - Studies on the role of neuronal subtype and differentiation state for cell replacemen in a rodent model of Parkinson's disease
… for PD and the available drug treatments only offer symptomatic relief and are often associated with severe side effects. Thus, there is an obvious need for alternative therapies. A promising alternative approach is cell replacement therapy, which aims to replacethe lost dopamine-producing …
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Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2
… disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. Clinical trials have shown that cell …
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Keratose Hydrogels Promote Vascular Smooth Muscle Differentiation from c-kit+ Human Cardiac Stem Cells: Underlying Mechanism and Therapeutic Potential
Cardiovascular disease is the leading cause of death in the United States, and coronary artery disease (CAD) kills over 370,000 people annually. There are available therapies that offer a temporary solution; however, only a heart transplant can fully resolve heart failure, and donor organ shortages …
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Alginate-based Hydrogels for Central Nervous System Tissue Regeneration
As the central nervous system shows very little capability for self-repair following injury, regenerative medicine approaches are increasingly interested in the use of stem cells for cell replacement strategies. Biomaterials are an interesting tool to carry out this type of therapies. They allow …
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Caracterização físico-química, anatômica e fisiológica de palmito pupunha para processamento mínimo
No palmito se distinguem três regiões: basal ou palmito caulinar; mediana ou palmito foliar e palmito foliar apical. O processamento convencional do palmito geralmente descarta as regiões apical e basal, sendo, no entanto, desejável seu aproveitamento integral. Objetivou-se avaliar características …