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Showing 1 to 14 of 14 for “"Ursolic acid"”.
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Ursolic acid and oleanolic acid as novel therapeutic agents in breast cancer
… The effects of non-toxic triterpenes, oleanolic acid and ursolic acid and the role of autophagy and apoptosis as mechanisms to overcome drug resistance in breast cancer were studied in vitro in MCF-7 breast cancer cells and MCF10A breast cells. In this study the first aim was to establish the …
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Synergistic inhibition of prostate tumor progression with a combination of curcumin and ursolic acid in the diet
… that two phytochemicals, Curcumin (Curc) and ursolic acid (UA), exert synergistic effects on tumor growth in a xenograft model of PCa. In the current studies, we demonstrated that Curc+UA administered through the diet significantly inhibited prostate tumor progression in two transgenic mouse …
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URSOLIC ACID INHIBITED PROLIFERATION AND INVASION OF MDA-MB-231 HUMAN BREAST CANCER CELLS VIA REGULATING CELLULAR SIGNAL TRANSDUCTION PATHWAYS
… to phytochemicals in fruits and vegetables. Ursolic acid (UA), a widely-distributed triterpenoid in fruits, vegetables, herbs, and spices, has been reported to have anti-cancer activities. However, its mechanism of actions against breast cancer remain unclear. The hypothesis of this study is …
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Antimycobacterial, docking and molecular dynamic studies of pentacyclic triterpenes from Buddleja saligna leaves
… Two isomeric pentacyclic triterpenes, oleanolic acid and ursolic acid, were isolated from the leaves of B. saligna using silica gel column chromatography. Compounds oleanolic acid and ursolic acid were subjected to derivatization with acetic anhydride in the presence of pyridine to obtain …
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ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΤΩΝ ΧΗΜΙΚΩΝ ΣΥΣΤΑΤΙΚΩΝ ΤΩΝ ΑΝΘΕΩΝ ΤΟΥ FRAXINUS ORNUS
… OF SUBSTANCES HAVE BEEN DETECTED: TANNINS, AMINO ACIDS (8 IDENTIFIED) POLYPHENOLS (FLAVONOID, COUMARINS) FREE SUGARS, TRITERPENES, MUCILAGE. THE SEARCH FOR SAPONINS, ALKALOIDS, GUINONES, AND ESSENTIAL OIL WAS NEGATIVE. B. MAIN RESEARCH. THE MATERIAL (DRIED FLOWERS) WAS SUCCESSIVELY EXTRACTED BY …
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Phytochemical and cytotoxicity studies on Arbutus pavarii, Asphodelus aestivus, Juniperus phoenicea and Ruta chalepensis growing in Libya
… (76); four diterpenes. 13-epi-cupressic acid (42), imbricatholic acid (41), 3-hydroxy sandaracopimaric acid (44) and dehydroabietic acid (46), one alkanol (heptacosanol) and two lignans, deoxypodophyllotoxin (29) and β-peltatin methyl ether (28)] from J. phoenicea leaves; one flavonoid, …
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Antimalarial activity of hypoxis colchicifolia, bak, mimusops caffra, E. Mey. ex A.DC and mimusops obtusifolia, lam from South Africa
… μg/ml). The pentacyclic tritepenoid (PTCs) ursolic acid isolated from the leaves of M. caffra was most active (IC50 = 6.8 μg/mL) in comparison to taraxerol and Sawamilletin isolated from the stem bark of M. obtusifolia with IC50 of > 100. Chemical modification of the ursolic acid to …
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Part A: Investigation of a newly identified plant Hernandia didymantha Donn, synthesis of phenethyl cinnamide Part B: Selective removal of ascaridol from the essential oil of Chenopodium ambrosioides var ambrosioides Part C: Synthesis of canophyllol analogues
… C16, and C18 saturated and unsaturated fatty acides. The presence of the ethyl ester of the CI7 fatty acid was indicated by GC-MS. The major non polar component was shown to be nerolidol, 4, an open chain sesquiterpene. Ethnobotanical reports indicate that this sesquiterpene can be used as a …
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Pharmacognostic study of 5 medicinal plant species from Western Cape Province (South Africa) for anti-tubercular activity
… the identification of pentacyclic triterpenoids, ursolic acid (UA) and oleanolic acid as major antitubercular constituents of B. saligna, L. gnaphaloides, and 1. graveolens. The in vitro cytotoxicity assays of the isolated bioactive constituents showed no cytotoxicity against Chinese Hamster …
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Leishmanicidal, anti-inflammatory and anti-obesity properties of natural products from common medicinal and edible plants.
… dogwood) afforded eight compounds: (1) betulinic acid, (2) ursolic acid, (3) β-sitosterol, (4) ergosta-4,6,8,22-tetraene-3-one, (5) 3β-O-acetyl betulinic acid, (6) 3-epideoxyflindissol, (7) 3β-O-cis-coumaroyl betulinic acid, (8) 3β-O-trans-coumaroyl betulinic acid. The most active leishmanicidal …
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Phytochemical studies on natural products and their biological activities against Trypanosoma
… effects, including eugenol, euginal, ursolic acid, carvacrol, linalool, limatrol, and caryophyllene. The phytochemistry of this plant is studied in the first section of this thesis.;Propolis is also receiving ample attention in the context of initiatives to discover novel drugs, thanks …
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Anti-inflammatory and anti-colon cancer potential of yerba mate (Ilex paraguariensis St. Hilaire) bioactive constituents
… extract, decaffeinated MT extract, chlorogenic acid (CHA), caffeine from MT (matein), mate saponins, quercetin, ursolic and oleanolic acids were tested by measuring their ability to inhibit COX-2/PGE2 and iNOS/NO pathways. Quercetin was the most potent inhibitor of pro-inflammatory responses at …
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PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR PRE-CLINICAL TARGETING OF PROSTATE CANCER
… drugs (nelfinavir, piperlongumine, and ursolic acid) mechanisms of actions can be clarified and used as putative therapeutic targets for prostate cancer. In summary this thesis provides evidence to support the ideas that: a) PC cells differentially utilize glucose, pyruvate, and …
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Elastase inhibitory, anti-inflammatory, and antioxidant potential of South African plants in a multi-faceted anti-ageing approach
… µg/ mL) compared to the positive drug control, Ursolic acid (5.03±0.47 µg/mL). These lead extracts were selected for further investigation to determine their in vitro cytotoxicity, anti-inflammatory potential using cyclooxygenase-I, cyclooxygenase-II and 5-lipoxygenase, and their propensity to …