Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Ursodeoxycholic acid (UDCA)"”.
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Developing novel prophylactic approaches against SARS-CoV-2 infection
… z-guggulsterone (ZGG) and the off-patent drug ursodeoxycholic acid (UDCA), downregulates ACE2 in human lung, cholangiocyte and intestinal organoids and in the corresponding tissues in mice and hamsters. I also show that UDCA-mediated ACE2 downregulation reduces susceptibility to SARS-CoV- 2 …
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Genetische Prädisposition der intrahepatischen Schwangerschaftscholestase : Mutationsanalyse des Phospholipidtransporters ABCB4 und der Gallensäurenexportpumpe ABCB11
… benefit from a therapy with the hydrophilic bile acid ursodeoxycholic acid (UDCA) substituting endogenous hydrophobic bile acids. Thereby the cytotoxic action of endogenous bile acids on cholangiocytes can be lowered below a critical threshold.
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Quantitative und qualitative Analyse der Derivate der Ursodeoxycholsäure im Urin gesunder Probanden
… and qualitative Analysis of Derivatives of Ursodeoxycholic Acid in urine of healthy human subjects Ursodeoxycholic acid (750 mg daily) was administered orally to ten healthy human subjects over a period of ten days. 24 hour urine samples were collected the day before and on the last day of …
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Mechanisms into the development of fatty liver disease: role of bile acids, Betaine and MHY908
… remains elusive, though it is known free fatty acids such as palmitate promote liver injury. Therefore, there is a pressing need to find a potent therapeutic approach for NAFLD. Firstly, this study aimed to investigate the lipotoxicity and mitochondrial dysfunction attributable to palmitic acid. …
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Immune activation at the lung epithelial barrier
… in the MLN. In chapter 4 we describe that bile acid ursodeoxycholic acid (UDCA) has immune regulatory properties by directly acting on the nuclear farnesoid X receptor on DCs. Treatment with UDCA during the secondary immune responses resulted in reduced features of allergic airway inflammation. …
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ROLE OF NATURAL KILLER CELLS IN THE PATHOGENESIS OF PRIMARY BILIARY CHOLANGITIS
… of now, anticholestatic therapy, in particular Ursodeoxycholic acid (UDCA), stands as the primary treatment approach for PBC, serving as the established first-line therapy irrespective of the disease stage. Unfortunately, up to 40% of PBC patients experience treatment failure with UDCA, facing …
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Diet in the promotion or prevention of colorectal cancer
… Initially, we focused on the effects of two bile acids, deoxycholic acid (DCA), with colon cancer promoting capacity, and ursodeoxycholic acid (UDCA), a chemopreventive compound, induced in Caco-2 cell line. We found that DCA in fact increase DNA damage and apoptosis in Caco-2 cell line. Also, …
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ΚΙΝΗΤΙΚΗ ΜΕΛΕΤΗ ΚΑΙ ΑΝΑΛΥΤΙΚΕΣ ΕΦΑΡΜΟΓΕΣ ΕΝΖΥΜΙΚΩΝ ΣΥΣΤΗΜΑΤΩΝ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΧΟΛΙΚΩΝ ΟΞΕΩΝ ΣΕ ΒΙΟΛΟΓΙΚΑ ΥΓΡΑ
… KINETIC STUDY OF ENZYMATIC SYSTEMS USING BILE ACIDS AS SUBSTRATES AND ITS APPLICATION FOR THE DETERMINATION OF BILE ACIDS ARE BASED ON THE SPECIFIC OXIDATION OF THEIR HYDROXYL GROUPS BY NICOTINAMIDE ADENINE DINUCLEOTIDE (B-NAD+) OR BY B-NADP+ IN THE PRESENCE OF HYDROXYSTEROID DEHYDROGENASES …