Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Uropathogenic E"”.
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Isolation and Characterization of Bacteriophages Targeting Uropathogenic E. coli
… common human bacterial infections, caused by uropathogenic E. coli (UPEC). Conventionally, UTI’s are treated with antibiotics, such as sulpha-mathoxazole/trimethoprim and ampicillin. However, a significant proportion of UPEC strains have become resistant to these antibiotics, resulting in a …
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Characterization of β-lactamases and Porins in Uropathogenic E. coli
Uropathogenic Escherichia coli, the predominant causative agent of urinary tract infections, are becoming increasingly resistant to commonly utilized β-lactam antibiotics leading to higher medical costs, prolonged treatment from persistent infections, and increased mortality. This rising resistance …
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An Investigation into the utilisation of ethanolamine by uropathogenic E. coli
… organism responsible for 75% of all cases. Uropathogenic E. coli (UPEC) naturally reside in the gastrointestinal tract (GI tract) and infect the urinary tract via migratory ascension of the urethra. Ethanolamine, an amino alcohol found naturally in phospholipids as phosphatidylethanolamine, …
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Analysis of the genome organization and fitness traits of non-pathogenic Escherichia coli strain Nissle 1917 (O6:K5:H1)
… those of analogous islands in the genome of uropathogenic E. coli strain CFT073 (O6:K2(?):H1), but they lack important virulence genes of uropathogenic E. coli (hly, cnf, prf/pap). Evidence for instability of GEI IINissle 1917 was given, since a deletion event in which IS2 elements play a …
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Studies on the Role of Histone-like Proteins in Gene Regulation in Uropathogenic Escherichia coli Isolate 536
… of histone-like proteins in gene regulation in uropathogenic Escherichia coli isolate 536 was monitored. The histone-like nucleoid structuring protein H-NS is a global regulator in Escherichia coli that has been intensively studied in non-pathogenic strains. No comprehensive study on the role of …
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Cranberry metabolites with urinary anti-adhesion activity
… blood cell (HRBC) anti-agglutination assay with uropathogenic P-fimbriated E. coli. Active urine fractions but not control urine or inactive fractions were found to contain complex mixtures of oligosaccharides but not PACs. An octasaccharide, consisting of a tetrameric, β-(1→4)-linked D-glucose …
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Investigating Bacterial Filamentation as a Survival Strategy for Infection
… bacteria such as Escherichia coli. Filamentous uropathogenic E. coli appear to play important roles in combating host defences during urinary tract infections through their decreased engulfment by phagocytic immune cells like macrophages. Bacterial filamentation, as a strategy to avoid …
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The Physiological and Morphological Responses of the Bladder Urothelium to Differential Injury
… we used a UTI injury model from instillation of uropathogenic E. coli: UPEC), a cellular damage model from single dose protamine sulfate: SDPS) instillation, and an inflammatory damage model from multiple instillations of lipopolysaccharide: LPS). We identified that UPEC injury increased the pain …
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Pilus biogenesis in uropathogenic Escherichia coli : An electrophysiology study on the PapC usher
Uropathogenic Escherichia coli are the main causal agents of urinary tract infections. Pili are bacterial surface adhesive organelles that are critical virulence factors in the successful colonization of the urinary tract by uropathogenic E. coli. Pili are composite in structure and are formed from …
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Studies on the architecture and on transferability of pathogenicity islands of uropathogenic Escherichia coli strain 536
… and functional analysis of DNA regions of uropathogenic Escherichia coli strain 536 that belong to the flexible E. coli gene pool. The first part of this thesis focused on the identification and structural characterisation of pathogenicity island V of strain 536 (PAI V536). PAI V536 is …
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INVESTIGATION OF ANTIBIOFILM AND ANTIVIRULENCE ACTIVITY OF 5-FLUOROCYTOSINE IN ESCHERICHIA COLI
… the expression of all major virulence factors of uropathogenic E. coli (UPEC) like curli fibers, secreted toxins, type I and P fimbriae, suggesting that the effect of 5-FC can also take place in clinically relevant isolates of E. coli. This result is further supported by the observation of …
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REGULATION AND EXPRESSION OF AMYLOID CURLI IN SALMONELLA INFECTION
… studies involving Burkholderia pseudomallei and uropathogenic E. coli revealed an association between nitrate reduction and biofilm dispersal and biofilm extracellular matrix (ECM) biosynthesis in vitro, respectively. Therefore, we investigated whether nitrate could serve as a signal for biofilm …
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Untersuchungen zum Einfluß der Pathogenitätsinseln I536 und II536 auf die Genexpression des uropathogenen Escherichia coli Stammes 536
Escherichia coli wird als der häufigste Erreger von Harnwegsinfektionen des Menschen beschrieben. Um die Krankheit auslösen zu können, benötigen die Bakterien ganz bestimmte Eigenschaften, die als Virulenzfaktoren bezeichnet werden und durch die sie sich von apathogenen Stämmen unterscheiden. Der …
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Toll like Receptor 4-Mediated Immune Responses in the Bladder Epithelium
<p>The urinary tract is one of the most intractable mucosal surfaces for pathogens to colonize. In addition to the natural barriers at this site, potential pathogens have to contend with the vigorous local innate immune response that is initiated by engagement of surveillance molecule TLRs. TLR4 …