Global ETD Search
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Showing 1 to 4 of 4 for “"Uricase"”.
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Reengineering a human-like uricase for the treatment of gout
… can be efficiently alleviated by the enzyme uricase. This enzyme breaks down uric acid, the causative agent of gout, so it can be flushed from the body. In humans and the other great apes, uricase is a pseudogene and as such is inactive. Research on therapeutic uricases has focused on using …
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Spray coated bentonite/MWCNT composite enzymatic biosensor for uric acid detection
… both electron transfer and long-term stability. Uricase (UOX) was immobilized on the BT/MWCNTs modified electrode using glutaraldehyde (GA) crosslinking, forming a stable enzyme matrix with strong adhesion and reduced leaching. The fabricated BT/MWCNT/GA/UOX biosensor was systematically …
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Gut Microbiome Dysbiosis Exacerbates Malaria Severity in Ugandan Children
… uric acid, which supports the growth of uricase producing bacteria such as Enterobacteriaceae. Furthermore, Enterobacteriaceae associated with multiple complications of SM such as coma, severe anemia, acidosis, acute kidney injury (AKI), and intestinal damage. Most positive blood cultures …
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Immune activation at the lung epithelial barrier
… PI3Kd signalling pathway. Treatment of mice with uricase at the time of HDM sensitization reduced the features of allergic airway inflammation. Chapter 6 shows that after HDM exposure, IL-1a is one of the key cytokines released by epithelial cells and acts in an autocrine loop to enhance Th2 …