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Showing 1 to 10 of 10 for “"Uracils"”.
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The Loss Of Genomic Uracil Homeostasis And Aid-Dependent Accumulation Of Dna Damage In B Cell Lymphomas
… DNA cytosine deaminase that introduces uracils in immunoglobulin genes. This DNA mutator is required for somatic hypermutation and class switch recombination- processes involved in the affinity maturation and diversification of antibodies. AID, however, can also lead to deleterious …
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Studies in the synthesis of pyrimidines, pyrazoles, and pyrazolo pyrimidines. New syntheses of 1, 3 and 5 substituted pyrazolo [3, 4-d] pyrimidines, including glycosides related to naturally occurring pyrimidines, imidazoles, purines and their nucleoside derivatives.
… methods for the facile synthesis of various uracils, pyrazoles and pyrazolo [3,4-d] - pyrimidines with alkyl, aryl and glycosyl substituents such that the nature of the ring substituents is easily varied. To this end a number of ethoxymethylene reagents were prepared which, by reaction with …
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Aspekte der Koordinationschemie des Zinks mit Nucleobasen, Nucleosiden und deren Derivaten als Liganden
… des Xanthins, Cytosins, Adenins, Diaminopurins, Uracils und Thymins wurden mit Hilfe der NMR-Spektroskopie auf Wechselwirkungen über Wasserstoffbrücken mit den Verbindungen 9-Isobutylguanin, 1-Isopropylcytosin, 1-Isopropylthymin bzw. 1-Methylthymin und 9-Ethyladenin untersucht. Für das Basenpaar …
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The Effect of Activation Induced Cytidine Deaminase Phosphorylation and Herpes Virus Uracil Dna Glycosylase On Antibody Diversification
… its recognition and removal of AID introduced uracils is essential in both SHM and CSR. Mice lacking AID or UNG are deficient in SHM and CSR resulting in a compromised immune system.</p> <p>Due to its mutagenic activity AID is heavily regulated by diverse mechanisms including post-translational …
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Single-Stranded Dna Scanning And Deamination With Single-Molecule Resolution
… based on the binding of Pfu polymerase to uracils formed upon C deamination by Apo3G. Scanning of Apo3G may consist of sliding and hopping/jumping as shown by its large salt dependency, whereas AID primarily uses sliding to scan the ssDNA, and is not sensitive to the changes in salt …
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Atm-/-Ung-/- Mice Present Reduced Levels of Switched Immunoglobulin Isotypes IgG1 and IgG3
… AID produces mutations that convert cytosines to uracils within the intronic switch regions that precede and follow the target immunoglobulin isotype coding sequence. To resolve the mutations, B cells conduct either base excision repair (BER) or mismatch repair (MMR). Inactivating genetic …
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Structural studies of the deaminase domain of the human HIV-1 restriction protein APOBEC3G
… provirus by deaminating the cytosines to uracils on the minus-strand viral cDNA. Consequently, A3G can genetically inactivate HIV and recent studies have demonstrated that this activity is as potent as any current anti-retroviral drug. However, the exact model of this mechanism at atomic …
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APOBEC3 Transcriptional Regulation and HIV-1 Restriction in T Lymphocytes
… enzymes catalyze the deamination of cytosines to uracils in viral reverse transcription intermediates, resulting in mutations that can render viral gene products non-functional. The HIV-1 Vif protein counteracts the antiviral activity of the APOBEC3 enzymes by commandeering a cellular ubiquitin …
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Investigations into the mode of action of the DNA uridine endonuclease Mth212 of Methanothermobacter thermautotrophicus ΔH
… für die Erkennung und Prozessierung des Uracils vorgeschlagen. Bei der kristallographischen Analyse von Mth212/D151N im Komplex mit spezifischen DNA-Substraten lag in allen Protein-DNA Komplexen ein exo-Bindungsmodus vor, wobei eines der 3"-Enden der DNA-Substrate im aktiven Zentrum …
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Synteza, analiza spektroskopowa oraz ocena aktywności biologicznej nowych pochodnych graminy
Celem rozprawy doktorskiej była synteza, analiza spektroskopowa oraz ocena aktywności biologicznej nowych pochodnych graminy. Gramina jest alkaloidem indolowym i wykazuje szeroką aktywność fizjologiczną. Jej pochodne znalazły praktyczne zastosowanie w wielu dziedzinach nauki, medycyny i przemysłu. …