Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Uracil-DNA Glycosylase"”.
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Isolation and Characterization of the Xiphophorus Maculatus Uracil-DNA Glycosylase Gene
No abstract prepared.
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The Effect of Activation Induced Cytidine Deaminase Phosphorylation and Herpes Virus Uracil Dna Glycosylase On Antibody Diversification
… locus where it deaminates cytosines to generate uracil residues in DNA. This generates guanine-uracil (U:G) mismatch lesion which are recognized by uracil DNA glycosylase (UNG), a DNA repair enzyme that removes uracil from DNA and triggers downstream repair of the lesion. While UNG is a …
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Computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil-DNA glycosylase enzyme
… the nature of binding of the 6-(4-Alkylanilino)-uracil inhibitors in hsvUDG and hUDG to provide a platform for the development of improved inhibitors.
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Uracil Accumulation Response To Folate Depletion Is A Function Of Dna Repair Imbalance That May Be A Mechanism Of Aging
… biological functions during many reactions, like DNA synthesis, RNA synthesis, DNA methylation, DNA repair, cell division and growth. Through biochemical techniques to determine the gene expression, enzyme activity, uracil level in DNA, and through microbiological assay to determine the folate …
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DNA Damage and Cell Death Mediated by Thymidylate Synthase Inhibitors: Role of UNG and SMUG1 DNA Glycosylase
… traditional chemotherapeutics such as 5-fluorouracil (5-FU) remain one of the most widely used agents for management of cancer in clinic. Currently, 5-FU is approved in USA for therapy of various cancers including that of colorectal and breast. Pharmacological actions of 5-FU are mediated by …
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Functional assessment of BRAF and CRAF through Base Editor 3 mutagenesis reveals residues and regions critical for ERK1/2 signalling
… nickase Cas9 fused to a cytidine deaminase and a uracil DNA glycosylase inhibitor. This can be used to generate high-efficiency C to T mutations. This thesis describes the use of a high efficiency BE3 mutation screen in an arrayed format with the high-throughput functional readout of p-ERK1/2 …
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Stemness status in differentiated and undifferentiated glioma cells
… be tested as potential biomarkers. They included Uracil DNA glycosylase (UDG), Phosphoglycerate kinase 1 (PGK1), Heterogeneous nuclear riboprotein K (HNRNPK) and moesin that can be used as differentiated markers for glioma cells. Vimentin, Eukaryotic translation initiation factor 4e (EIF4e), …
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Atm-/-Ung-/- Mice Present Reduced Levels of Switched Immunoglobulin Isotypes IgG1 and IgG3
… AID produces mutations that convert cytosines to uracils within the intronic switch regions that precede and follow the target immunoglobulin isotype coding sequence. To resolve the mutations, B cells conduct either base excision repair (BER) or mismatch repair (MMR). Inactivating genetic …
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The Loss Of Genomic Uracil Homeostasis And Aid-Dependent Accumulation Of Dna Damage In B Cell Lymphomas
… deaminase (AID) is a sequence-selective DNA cytosine deaminase that introduces uracils in immunoglobulin genes. This DNA mutator is required for somatic hypermutation and class switch recombination- processes involved in the affinity maturation and diversification of antibodies. AID, …
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THE ROLE OF DNA REPAIR IN DNA METHYLATION DYNAMICS
… involves the erasure and re-establishment of DNA methylation by both passive and active mechanisms, including DNA repair pathways, and occurs concurrently with an increase in developmental potency. In addition to Uhrf1 and the Tet enzymes, the interplay between activation induced cytidine …
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Identifizierung und Charakterisierung von thermostabilen Uracil Glykosylasen von Archaeon Methanobacterium thermoautotrophicum und Bakterium Thermus thermophilus
… (BER) vorgeschlagen und die Wirkung von Uracil und T/G, U/G "Fehlpaarungen" spezifischen DNA-Glycosylasen postuliert. Mit dem Ziel das Wissen über U/G und T/G entfernende Enzyme zu vertiefen, lag der Fokus dieser Arbeit in der Isolierung und enzymatischen Charakterisierung …