Global ETD Search
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Showing 1 to 2 of 2 for “"Upc2A"”.
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Delineating the Upc2A Regulon in Candida glabrata
… sterol biosynthesis genes in yeast. Disrupting UPC2A in C. glabrata greatly increases its susceptibility to fluconazole (FLU) in both FLU-susceptible and -resistant clinical isolates. Therefore, the Upc2A and its target genes represent a potential pathway for overcoming FLU resistance in C. …
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Novel Determinants That Influence Azole Susceptibility in Candida glabrata and Candida albicans
… homologs for these transcription factors, <em>UPC2A </em>and <em>UPC2B</em>, were identified in <em>C. glabrata</em>. One of these, <em>UPC2A</em>, was shown to influence azole susceptibility. We hypothesized that due to the global role for Upc2 in sterol biosynthesis in <em>S. cerevisiae …