Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 429 for “"Up-Regulation"”.
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Epidermal Growth Factor Receptor Induces Fyn Expression Via Up-Regulation of P47Phox In Glioblastoma Multiforme
… well described; however, the SFK Fyn is commonly up-regulated at the mRNA level in multiple human cancers, including GBM, where the mode of increased expression is poorly understood. Since activating mutations in the epidermal growth factor receptor (EGFR) are commonly occurring in GBM, we …
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Up-regulation of junctophilin-2 prevents ER stress and apoptosis in hypoxia/reoxygenation-stimulated H9c2 cells
… Ca2+ release for stable excitation-contraction coupling. Down-regulation of JPH2 has been observed in diseased hearts and is related to cardiac dysfunction and T-tubule remodeling. In this study, we show that the protein levels of JPH2 are down-regulated in cardiomyocytes following …
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Regulatory Regions required for β-Defensin-2 Up-regulation by Interleukin-1α in the Human Middle Ear Epithelial Cell Line
… luminometer after corresponding substrate was supplemented to the cell lysate. RESULTS: hBD-2 was upregulated by IL-1a in HMEEC-1. The treatment of IL-1a upregulates the activity of promoter 7.60±1.45 (average ± standard deviation) folded in 2.7kpb sized 5’ flanking region, 3.81 ± 0.78 folded in …
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Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
… resistance arteries. 2. The level of the up-regulation of contractile AT1 and ETB receptors depends on the degree of underlying IHD. The phenomenon is also correlated to the level of the systolic blood pressure. 3. Temporal arteries from patients with GCA have up-regulation of AT1 and ETB …
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Mechanism of Chimeric Vaccine Mediated Immune Suppression of Human Dendritic Cells
… of vaccine inoculated DCs revealed strong up-regulation of the tryptophan catabolic enzyme indoleamine 2, 3-dioxygenase (IDO1) shown to be directly linked to CTB-INS-induced DC activation and maturation. Treatment of vaccinated DCs with the pharmacological NF-κB inhibitors ACHP or DHMEQ …
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Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development
Disruptions in glutamatergic neurotransmission may play a role in the pathogenesis of schizophrenia. The purpose of this study was to determine phencyclidine (PCP)-induced changes in the NMDA receptor subunit composition and the relationship of these changes to the deficits in pre-pulse inhibition …
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The effect of hypoxia on ER-β expression in the lung and cultured pulmonary artery endothelial cells
… we hypothesized that hypoxia selectively up-regulates ER-β in the lung and pulmonary endothelial cells. In our Male Sprague-Dawley rat model, chronic hypoxia exposure (10% FiO2) resulted in a robust HPH phenotype associated with significant increases in ER- β but not ER-α protein in the …
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The effect of fasting on anti-inflammatory mediators, IL-1RA and IL-1R2, and their role in resistance to sickness behaviors in mice
… in addition to brain and uncovered a major up-regulation of IL-1 endogenous inhibitors, IL-1RA and IL-1R2 in peripheral tissues. These findings imply that attenuation in sickness behaviors observed may be due to counter-regulation of IL-1 via up-regulation of IL-1R2 and/or IL-1RA shown in …
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Molecular characterization and functional analysis of cytochrome P450 genes in the yellow fever mosquito Aedes aegypti (Diptera: Culicidae)
… and deltamethrin) resulted in either down or up-regulation of these transcripts. Functional analyses of the selected P450 transcripts were conducted by using RNA interference (RNAi) followed by insecticide bioassay. RNAi was achieved by feeding mosquito larvae with chitosan/double stranded RNA …
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Involvement of TGF-beta in skin photoaging
… is a multifunctional cytokine involved in the regulation of extracelluar matrix and is known to be up-regulated by UVR. Involvement of reactive oxygen species (ROS) in the development of solar elastosis has been demonstrated by many studies using antioxidants and anti-inflammatory agents in the …
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Next Generation Sequencing Reveals Gene Expression Patterns in the Zebrafish Inner Ear Following Growth Hormone Injection
… remain elusive. To understand the gene regulation during hair cell regeneration, our previous microarray study on zebrafish inner ears found that growth hormone (GH) was significantly upregulated after noise exposure. In this current study, we utilized Next Generation Sequencing (NGS) to …
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Gene expression profiling in Saccharomyces cerevisiae grown at different specific gravity environments
… manner. The repressed expression of GDH1 and up-regulation of ARO10 within the contrast of Q270/Q10 indicated high energy demanding of yeast cells under high sugar stress. Activities of G3P shuttle indicated that under very high gravity environment, sufficient assimilatory nitrogen enhances …
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Regulating the anterior medial prefrontal cortex : exploratory investigation of real-time fMRI training
… prefrontal cortex (rMPFC) to learn improved regulation of this brain area was examined in a group of 5 young adults. Subjects received real-time feedback from the target brain region while engaging in a blocked-design task involving alternating blocks of attempted up-regulation and …
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The Role of Transforming Growth Factor Beta Signaling in Inflammation-Dependent Colon Cancer
… the addition of H. hepaticus resulting extreme up-regulation of TLR4 and the downstream effectors IRAK4 and NF-κB in Smad3⁻/⁻-infected colonic tissues. Examination of adaptive immune regulation in this model demonstrated that SMAD3 was necessary for FOXP3 expression in H. hepaticus-infected …
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The role of matrix metalloproteinases and their inhibitors in irinotecan-induced oral mucositis: an animal model.
… painful ulcerations and erythematous eruptions and occurs in between 40-100% of all patients undergoing chemotherapy. Currently, there are no standard treatments available to prevent oral mucositis and the consequences on health care systems remain extensive. Research into the …
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Genetic effects of prolonged UV-B exposure in a Namaqualand daisy - Dimorphotheca sinuata
… of photosynthetic function, involving a down-regulation of photosynthetic genes and an up-regulation of flavonoid biosynthesis.
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The mode of action of a lipid mobilising factor in cancer cachexia
… of lipid in the liver. There was also up-regulation of uncoupling protein-1 and -2 mRNA and protein expression in brown adipose tissue, suggesting that an adaptive process occurs due to increased energy mobilisation. There was also up-regulation of UCP-2 in the livers of LMF treated …
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The role of podovirus-like bacteriophage in the virulence of Vibrio harveyi strain 47666-1
… with the phage VHPL. SDS-PAGE analysis showed an up regulation and production of extracellular proteins in previously naïve V. harveyi strains receiving this phage compared with uninfected strains. Haemolysin assays indicated a significant increase (P<0.001) in both halo of clearing and colony …
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