Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 133 for “"Untranslated Region"”.
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Regulating transcript fate through RNA elements in the 3' untranslated region
… and sequences located primarily in the 3' untranslated region (3'UTR), termed RNA motifs or RNA elements. A common mechanism of post-transcriptional control is guided by small non-coding RNAs (sncRNAs) such as microRNA or piRNA, where proteins are guided to their target transcripts via …
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Development of an Attenuated Zika Virus by Editing the 5’ Untranslated Region
… several different nucleotide lengths into the 5’ untranslated region (UTR) of the viral genome. We generated a viable mutated ZIKV virus (Z7) was after inserting a 50-nt sequence into the 5’UTR. We then characterized Z7 by comparing growth kinetics <em>in vivo</em> replication by using qPCR and …
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Regulation of Salmonella pathogenicity island I through the hilD mRNA 3' untranslated region
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Investigating the importance of the Zika virus 3′ untranslated region to viral fitness
… been shown to bind to the Zika virus (ZIKV) 3′ untranslated region (3′UTR) and enhance viral replication. MSI1 is present in high levels in neural progenitor cells of the foetal brain, and previous work proposed that MSI1 could drive the pathogenesis caused by ZIKV, and therefore, could be …
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Characterization of the 5̕ untranslated region ( 5̕ UTR) of the alcohol oxidase I (AOX I) gene in Pichia pastoris.
… on the characterization of the 122 nucleotide 5' Untranslated Region (UTR) of the Alcohol Oxidase I (AOXI) gene in Pichia pastoris. The 5' UTR influences the expression of many heterologous proteins in P. pastoris. However, no systematic analysis has ever been performed on this region to date. …
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Isolation and Characterization of a Full Length Retrotransposon: CR1
… Goose using probes complimentary to the flanking regions of the element. The findings unveiled sequences with a complete ORF1, ORF2, 3' untranslated region and a portion of the 5' untranslated region. This study gets one step closer a further understanding the transposition mechanism that are …
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Characterization of features of the initiation of translation of satellite tobacco necrosis virus RNA
… RNA were shown to reside in the 5$\sp\prime$-untranslated region by replacing these upstream sequences with either a random sequence or the 5$\sp\prime$-untranslated region of brome mosaic virus RNA 4. Such a replacement caused a loss of translation when the mutant RNA was made without a cap. …
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The Mechanism of Cap-Independent Initiation of Translation of Satellite Tobacco Necrosis Virus RNA
… cap group. Interestingly, the 5$\sp\prime$-untranslated region of STNV RNA contains a nucleotide sequence that is complementary to the 3$\sp\prime$-terminal region of the 18S rRNA.
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Expression Of Hepatitis C Viral Non-structural 3 Antigen In Transgenic Chloroplasts
… for the spectinomycin selectable marker, psbA 5' untranslated region to enhance translation in the light and 3' untranslated region for transcript stability and trnI & trnA homologous flanking sequences for site specific integration into the chloroplast genome. Chloroplast integration of the NS3 …
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Functional analysis of A 5' untranslated variant in rhodopsin : implications for the retinitis pigmentosa phenotype
… of RP. A sequence variant identified in the 5' untranslated region of RHO, g.269A>G, also known as c.-26A>G, was proposed to increase the risk of developing RP. In this study, the functional effect of this variant, individually and in cis with known pathogenic variants, was investigated using …
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Knockout of the trans-acting riboswitches in Listeria monocytogenes to disrupt downstream virulence factors
… plasmid is used in an attempt to knock-out the untranslated region (UTR) of the prfA gene located on the LIPI-1 pathogenicity island of the L. monocytogenes.</p>
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Esi47, a stress-inducible protein kinase gene from Lophopyrum elongatum is involved in plant hormone signaling
… Esi47 gene revealed that it contains in the 5 ' -untranslated region of its mRNA a small upstream open reading frame that has been demonstrated to mediate the ABA regulation of Esi47 expression in an independent study. Three Arabidopsis homologs of Esi47 were identified and different members of …
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Isolation of novel ABF-1 splice forms
… five clones harboring changes within the coding region of the reported full-length ABF-1 eDNA. In some cases, these changes resulted in the elimination of the coding region specifying the bHLH domain and likely affect DNAbinding and dirnerization of ABF-1. For the other retrieved splice products, …
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Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes
… variants within the functional COL5A1 3’- untranslated region (UTR) have previously been associated with (1) chronic Achilles tendinopathy, (2) Anterior Cruciate Ligament (ACL) ruptures in females, (3) endurance running performance and (4) range of motion (ROM). Since this gene encodes for …
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Isolation of the aldose reductase gene (XvAld1) from the resurrection plant Xerophyta viscosa, and characterisation of the gene product and transgenic plants expressing the gene
… copies of the gene. An 870-bp clone of the 5′ untranslated region, matching the 5′ leader sequence on the XvAld1 cDNA was analysed for cis-acting response elements. Many of the sequence motifs matched those for hormonal regulation, organ specific expression, dehydration, high or low temperature …
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MiR-145 is a tumor suppressor in both tumor progression and metastasis
… level by interacting with the 3'-untranslated region (3'-UTR) of a target gene. Our previous studies indicate that miR-145 is downregulated in breast and colon cancer; moreover, it functions as a tumor suppressor capable of inhibiting tumor cell growth both in vitro and in vivo. In …
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Enhancing mRNA stability through the addition of stabilizing untranslated regions
… gene was prepared with four different hemoglobin untranslated regions (UTR's), which are known for their stabilization effects on mRNA. Each mRNA template was created through the digestion and ligation of a cDNA template, reversed transcribed from total RNA, and transfected into fibroblasts. The …
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Studies of the UNC-45A Molecular Chaperone Expression in Human Cancer
… cells. UNC-45A(a) 929 isoform had a long 5' untranslated region (UTR) and 944 isoform had a specific 15 amino acid sequence close to its N-terminus. Furthermore, we showed that UNC-45A 929 accumulated higher level in human breast cells. More importantly, the ubiquitin-proteasome system …
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Studies of the UNC-45A Molecular Chaperone Expression in Human Cancer
… cells. UNC-45A(a) 929 isoform had a long 5' untranslated region (UTR) and 944 isoform had a specific 15 amino acid sequence close to its N-terminus. Furthermore, we showed that UNC-45A 929 accumulated higher level in human breast cells. More importantly, the ubiquitin-proteasome system …
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