Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 128 for “"Unfolded Protein Response"”.
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Stress-signal recognition in the unfolded protein response
The unfolded protein response (UPR) maintains protein folding homeostasis in the endoplasmic reticulum (ER) by adjusting its folding capacity to the load of unfolded proteins in the compartment. This critical feedback mechanism governs the functioning of the secretory pathway, impacting various …
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Contribution of the Unfolded Protein Response to VEGF Expression
… interfere with the proper maturation of nascent proteins synthesized there. The resultant accumulation of unfolded proteins activates a signal transduction pathway known as the Unfolded Protein Response, which serves primarily to protect the cell during stress and helps restore homeostasis to …
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Regulation of the unfolded protein response by GADD34 and CReP
<p>The regulation of protein synthesis and protein folding is crucial for normal cell function. The endoplasmic reticulum (ER) has crucial roles in safeguarding the correct folding and assembling of proteins through the use of ER molecular chaperones. Homeostasis disruption of the ER leads to …
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Role of SLMAP in Endoplasmic Reticulum Stress and Unfolded Protein Response
… Disruptions in homeostatic balance of these proteins and calcium regulation results in activation of ER stress response. Sarcolemmal membrane-associated proteins (SLMAPs) are found in cell membrane, SR/ER, and mitochondria. Overexpression of SLMAP in the myocardium has shown to impair …
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Modeling The Unfolded Protein Response And Its Connection To Cellular Stress
… plays a pivotal role in cellular functioning. Proteins undergo modifications in the ER. The cell monitors protein folding and has a quality control. The incorrectly folded proteins are tagged for degradation or sent back to the refolding cycle. Upon accumulation of incorrectly folded proteins …
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Translational Control by the Ribosome-Associated Complex in the Unfolded Protein Response
… implies the coordinating role of de novo protein folding with translation. Deletion of RAC causes growth defects and sensitizes to osmotic, cold, and aminoglycoside stresses in yeast. Furthermore, studies have shown that Mpp11 is over-expressed in head and neck squamous cell cancer and …
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Mitochondrial Unfolded Protein Response Regulator Atf5 In Mitochondrial Targeted Therapies In Aml
<p>Mitochondrial unfolded protein response (UPR<sup>mt</sup>) is an adaptive transcriptional response induced by damaged proteins accumulated in mitochondria. UPR<sup>mt</sup> signaling involves induction of mitochondrial specific chaperones and proteases such as HSP60, LonP1 and ClpP, aiding in …
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The unfolded protein response and HLA-B27 misfolding: implications for ankylosing spondylitis
The unfolded protein response (UPR) detects the presence of misfolded proteins in the endoplasmic reticulum (ER) and subsequently relieves ER stress by increasing the folding capacity of the ER. The secretory pathway substrate HLA-B27 is highly associated with the chronic inflammatory disease …
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The anticipatory unfolded protein response and estrogen receptor mutations in breast cancer
… endoplasmic reticulum and mild activation of the unfolded protein response. I identified that this anticipatory UPR is a conserved pathway shared by different mitogenic hormones including epidermal growth factor, estrogen and progesterone. EGF rapidly induced a calcium increase in the cytosol and …
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Modulating The Unfolded Protein Response as a Therapeutic Target in Alzheimer’s Disease
… are implicated in Alzheimer’s disease is the unfolded protein response (UPR). Previous basic science work has suggested that the UPR becomes and remains activated during disease which stops or diminishes protein synthesis. This, in turn, means that proteins essential for synaptic and neuronal …
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Exploring the role of the unfolded protein response in C. elegans neurons
… a role in the orchestration of systemic stress responses. One of these stress responses, the unfolded protein response of the endoplasmic reticulum (UPRER), is activated to re-establish protein homeostasis (proteostasis) upon the detection of ER stress. Overexpression of active, spliced XBP-1 …
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The unfolded protein response regulates hepatocellular injury during the pathogenesis of nonalcoholic steatohepatitis
… of cellular stress pathways such as the Unfolded Protein Response (UPR), an adaptive response to disruptions in endoplasmic reticulum (ER) homeostasis. Because the role of the UPR in the progression of liver disease is not well understood, we established an in vitro model to evaluate the …
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IMPACT OF DRP1 ACTIVATION, UNFOLDED PROTEIN RESPONSE INDUCTION AND FGF21 LEVELS IN DMD PROGRESSION
… that lead to the complete loss of dystrophin protein are responsible for this very severe phenotype. Dystrophin is a subsarcolemmal protein that not only provides structural integrity and functional stability to the muscle fiber during contraction but also plays crucial roles in cell signaling …
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The Unfolded Protein Response Increases Production of Pro-Angiogenic Factors by Tumor Cell Lines
… negatively affect the proper folding of nascent proteins in the endoplasmic reticulum (ER) and lead to accumulation of unfolded protein within ER which is referred to as ER stress. Consequently, it will trigger the unfolded protein response (UPR) signal pathway through ER membrane stress sensor …
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Investigating the role of the Caenorhabditis elegans unfolded protein response in immunity and development
Proteins destined for the secretory pathway are folded, posttranslationally modified, and assembled into complexes in the endoplasmic reticulum (ER). To maintain ER proteostasis, the rate of nascent peptide influx into the ER must be matched with the rate of protein folding and export. An imbalance …
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Regulation of autophagy, endoplasmic reticulum and unfolded protein response by glucocorticoids in physiology and disease
… endoplasmic reticulum stress (ER stress) and unfolded protein response (UPR) respectively, in acute lymphoblastic leukemia cell lines including CEM-C1-15, CEM-C7-14 and Molt4. The results showed that autophagy inhibition by CLQ increased cell death and combination treatment with Dex exerted …
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Necrotic cell death: A novel outcome of BHPI-hyperactivation of the anticipatory unfolded protein response
… ERa to hyperactivate a lethal anticipatory unfolded protein response (UPR), hijacking a normally protective and pro-proliferative action of estrogen and ERa. We have found that BHPI effectively inhibits proliferation of and kills breast cancer cells expressing constitutive and antiestrogen …
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How activating the protective and cytotoxic anticipatory unfolded protein response controls transcription and cancer cell death
Embargo set by: Seth Robbins for item 123454 Lift date: 2024-04-29T21:58:46Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system
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Investigating the potential of enhanced neuroprotection through unfolded protein response inhibition and autophagy induction in neurodegeneration
… neurodegenerative diseases are classified as protein misfolding diseases (PMDs). Despite their uniqueness, these PMDs share common pathways connected to their pathophysiology. Preclinical evidence demonstrates that these can be manipulated for new disease-modifying drug therapies. The unfolded …
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