Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Under-replication"”.
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Post-Replicative Resolution of Under-Replication
The evolutionary pressure to prevent re-replication by inactivating licensing during S phase leaves higher-eukaryotes with large genomes, such as human cells, vulnerable to replication stresses. Origins licensed in G1 must be sufficient to complete replication as new origins cannot be licensed in …
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Priming the Data: Examining Self-Potentiation in a Word Fragment Completion Task
… Priming effects have suffered a plethora of replication issues, and the field is currently under intense scrutiny. By analyzing and refining the methodology used, we will be able to more effectively evaluate the significance and strength of these effects in future research, and increase the …
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Human common fragile sites, identification, and analysis of breaks using <i>saccharomyces cerevisiae</i>
… which are areas of the genome prone to breaks under replication stress, are frequently altered in tumor cells. Two hypotheses have been proposed to explain why common fragile sites break: (1)AT-rich segments with high flexibility in the fragile site fold into secondary structures, leading to …
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Elucidation and characterisation of checkpoint kinase interactions with the replisome
… copied in each cell cycle by the process of DNA replication. During replication, cells must endure assaults from a myriad of exogenous and endogenous agents and events which can interfere with replication. Cells have evolved a surveillance mechanism called the DNA replication checkpoint (DRC) …
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INVESTIGATING THE LINK BETWEEN HOMOLOGOUS RECOMBINATION PROTEIN BRCA2 AND DNA METHYLATION
… (HR) proteins BRCA2 which protects DNA replication intermediates from nuclease-mediated degradation. Emerging evidence demonstrates that HR proteins like BRCA2 co-evolved with the cytosine methylation machinery, suggesting a functional link between the two processes. Cytosine methylation …
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Low Molecular Weight Cyclin E Deregulates Dna Replication and Damage Repair to Promote Genomic Instability In Breast Cancer
… function(s) independent of FL-cycE are not fully understood. It is currently assumed that LMW-E drives the tumorigenic process by promoting G1/S cell cycle transition and accelerating mitotic exit. Biochemical features such as longer protein half-life, higher affinity to its kinase partner CDK2, …