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Showing 1 to 13 of 13 for “"Uncoupling protein 1"”.
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Structure and regulatory mechanism of human uncoupling protein 1
Uncoupling protein 1 (UCP1) in the mitochondrial inner membrane is responsible for the thermogenic properties of brown adipose tissue. In response to cold exposure, UCP1 is activated by free fatty acids and catalyses proton leak, dissipating the proton motive force, which mitochondria use to drive …
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The mechanistic action and application of a beta-3 selective adrenergic modulator (LY488756) in finishing cattle
Animal-derived food products provide protein, vitamins, and minerals necessary for a healthy diet. In the next few decades, the expansion of global animal agriculture will be forced to keep pace with an expected world population growth of 2.3 billion people. Feeding the growing world will either …
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The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism
… fat mass. There was a significant induction of uncoupling protein 1 (UCP1) in the brown adipose tissue (BAT) of IIA+ mice, suggesting enhanced mitochondrial uncoupling in their adipose tissue to drive this metabolic phenotype. Previous work in Dr. Park’s laboratory suggested that hepatic PLA2G2A …
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The mode of action of a lipid mobilising factor in cancer cachexia
… in the liver. There was also up-regulation of uncoupling protein-1 and -2 mRNA and protein expression in brown adipose tissue, suggesting that an adaptive process occurs due to increased energy mobilisation. There was also up-regulation of UCP-2 in the livers of LMF treated mice, suggesting a …
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Adrenergic control of proteolysis in brown adipocytes
… tissue atrophy by loss of cells, mitochondrial proteins, and uncoupling protein 1 (UCP1), the molecular basis for thermogenesis. The overall objective is to gain a better understanding of the control and the mechanisms underlying BAT atrophy. Specific objectives are: (1) whether in vivo patterns …
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Glucose and Lipid Dysregulation Following Loss of Hepatic Aryl Hydrocarbon Receptor in Mice.
… and increased expression of thermogenic gene, uncoupling protein 1 (UCP1) or the browning of the white adipose tissue (WAT) vs. controls. Next generation RNA sequencing of AhR-CKO vs. control mice liver transcriptomes revealed significantly increased expression of fibroblast growth factor (FGF) …
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Investigation of the proteomic interaction profile of uncoupling protein 3 and its effect on epigenetics
Uncoupling proteins (UCPs) are localized on the inner mitochondrial membrane (IMM) and “uncouple” the electrochemical proton gradient formed by the electron transport chain (ETC) from ATP production. Though the prototypical uncoupling protein 1 (UCP1) is known to mediate the cold-induced …
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The Reprogramming of White Adipose Tissue to Brown Adipose Tissue Mediates Adverse Metabolic Dysfunction After A Burn Injury
… characterized by hyperglycemia, lipolysis, and protein catabolism. Perhaps the most serious gap in our understanding of the hypermetabolic response in burns is the role of the adipose tissue. Humans harbour two distinct adipose depots, white adipose tissue (WAT) and brown adipose tissue (BAT) …
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Examination of voluntary wheel running on markers of adipose thermogenesis in intact and ovariectomized female mice
… of brain-derived neurotrophic factor (BDNF) and uncoupling protein-1 (UCP1) in adipose tissue. This study aimed to investigate the effect of voluntary wheel running (VWR) in ovariectomized (OVX) mice on whole body energy expenditure and body composition, key protein markers of thermogenesis and …
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Using immune cells to combat obesity: adipose eosinophils as mediators of metabolic homeostasis
… increased endothelial cells, and increased uncoupling protein 1 (Ucp1) expression, indicating an elevation in thermogenic beige adipose tissue. Cold exposure is the main stimulus for beige adipose tissue activation. It is well understood that the cold activation of beige adipose tissue …
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Struktur- und Funktionsanalyse der humanen Uncoupling Proteine 1, 2 und 3 (hUCP1, hUCP2 und hUCP3)
… 1997 wurden zusätzlich zu dem bekannten Uncoupling Protein (UCP1) im braunen Fettgewebe (BAT) die humanen Uncoupling Proteine 2 und 3 (hUCP2, hUCP3) entdeckt, die in verschiedenen Geweben des Menschen vorkommen. In den Mitochondrien von Nagetieren und Winterschläfern fungiert das …
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Anti-Obesity Effects of Adipose-Targeting Resveratrol Nanocarriers
… and dose-dependently induced mRNA expression of uncoupling protein 1 (UCP-1) in 3T3-L1 cells under an isoproterenol (ISO)-stimulated condition. To impart ASC target specificity, we have conjugated ASC-targeting peptide (sequence: GSWKYWFGEGGC) to …
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REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY ARYL HYDROCARBON RECEPTOR
… In addition, Real-time PCR data show that uncoupling protein 1(Ucp1) is higher in brown adipose tissue which supports the higher heat production; moreover, the muscle gene profile reveals that the fatty acid beta-oxidation genes and mitochondrial respiratory genes are higher in AHR+/- mice …