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Showing 1 to 20 of 146 for “"Uncoupling"”.
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Uncoupling Lipid Metabolism from Inflammation in Adipose Tissue
… defined. In my thesis research, we identified uncoupling protein 2 (UCP2) and Sirtuin 3 (Sirt3) as important mediators of the anti-inflammatory phenotype in FABP4 deficient macrophages. Increased expression of UCP2 in FABP4 null macrophages contributes to both suppressed inflammation and …
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Structure and regulatory mechanism of human uncoupling protein 1
Uncoupling protein 1 (UCP1) in the mitochondrial inner membrane is responsible for the thermogenic properties of brown adipose tissue. In response to cold exposure, UCP1 is activated by free fatty acids and catalyses proton leak, dissipating the proton motive force, which mitochondria use to drive …
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Biochemical Studies on Uncoupling Proteins and Glucose Metabolism in Skeletal Muscle
Uncoupling protein (UCP) is an inner-mitochondrial membrane protein that uncouples the production of ATP from the electron transport chain, thereby inducing thermogenesis. Recently, a family of UCP homologues was identified, two of which (UCP-2 and UCP-3) are highly expressed in skeletal muscle. …
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Fundamental Studies of Chemical Looping Combustion with Oxygen Uncoupling (CLOU) of Biomass Char
… using Chemical Looping Combustion with Oxygen Uncoupling (CLOU), a variant of CLC in which the oxygen carriers can release gaseous oxygen. In CLOU, the gaseous O₂ released from the oxygen carriers reacts heterogeneously with the particles of char, producing a mixture of combustion products, CO …
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Computational and experimental detection of uncoupling between transcriptome and translatome changes of gene expression
… From the comparison of the results an extensive uncoupling between transcriptome and translatome variations of mRNA levels emerges, measured by a significant difference between steady state and polysomal fold changes induced by a cellular physiological or pathological transition. It seems clear …
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Evaluating mitochondrial uncoupling potentials of A7E and DNP in Saccharomyces cerevisiae : implications for human obesity
… death. Weight loss supplements frequently claim uncoupling as a mechanism of action. Uncoupling agents could be used for weight loss because they disrupt mitochondrial metabolism thereby reducing adenosine triphosphate (ATP) yield. Consequently, metabolic efficiency diminishes increasing basal …
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Investigation of the proteomic interaction profile of uncoupling protein 3 and its effect on epigenetics
Uncoupling proteins (UCPs) are localized on the inner mitochondrial membrane (IMM) and “uncouple” the electrochemical proton gradient formed by the electron transport chain (ETC) from ATP production. Though the prototypical uncoupling protein 1 (UCP1) is known to mediate the cold-induced …
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Struktur- und Funktionsanalyse der humanen Uncoupling Proteine 1, 2 und 3 (hUCP1, hUCP2 und hUCP3)
… 1997 wurden zusätzlich zu dem bekannten Uncoupling Protein (UCP1) im braunen Fettgewebe (BAT) die humanen Uncoupling Proteine 2 und 3 (hUCP2, hUCP3) entdeckt, die in verschiedenen Geweben des Menschen vorkommen. In den Mitochondrien von Nagetieren und Winterschläfern fungiert das …
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Studies on the Uncoupling Action of 2,4-Dichlorophenoxyacetic Acid as a Basis for Growth Inhibition
Made available in DSpace on 2014-12-10T17:12:22Z (GMT). No. of bitstreams: 1 6507077.pdf: 6998312 bytes, checksum: 4c8e4498f97985203b5d21b21616bc44 (MD5) Previous issue date: 1965
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Uncoupling sweetness and energy in habitual high and low consumers of artificial sweetners: effects on appetite
… however, sweetness and energy can be uncoupled. Uncoupling sweetness and energy, the consumption of artificial sweeteners may have profound effects on appetite and appetite control. Uncoupling sweetness and energy in the single consumption of artificial sweeteners has previously been widely …
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Intrinsic uncoupling in the ATP synthase of Escherichia coli. Studies on WT and ε-truncated mutants
… for evidence of this phenomenon of intrinsic uncoupling in this organism as well. First of all, we have shown that the DCCD-sensitive ATP hydrolysis activity of E.coli internal membranes was strongly inhibited by ADP and Pi, with a half-maximal effect in the submicromolar range for ADP and at …
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Development and characterisation of a copper-based oxygen carrier for chemical-looping with oxygen uncoupling (CLOU)
In chemical-looping, a fuel is oxidised by a solid metal oxide, MeO, in one reactor: (2$n+m$)MeO+C$_{n}$H$_{2m}\rightarrow$(2$n+m$)Me+$m$H$_{2}$O+$n$CO$_{2}$. The exit gas yields pure CO$_{2}$ after the steam has been condensed. The reduced metal oxide, Me, is transferred to an oxidation reactor …
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Functional and structural uncoupling of the angiogenic and enzymatic inhibitory activity of TIMPs : loop 6 of TIMP-2 is a novel inhibitor of angiogenesis
Tissue inhibitors of metalloproteinases (TIMPs) regulate tumor growth, progression and angiogenesis in a variety of experimental cancer models and in human malignancies. However, numerous studies have revealed important differences between TIMP family members in their ability to inhibit angiogenic …
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Design and Synthesis of Mitochondrial Uncouplers for the Treatment of Mitochondrial Dysfunction
… respiration facilitated by membrane bound uncoupling proteins. Uncoupling proteins create leaks in the inner mitochondrial membrane (IMS), shuttling protons against the electrochemical gradient independent of ATP production. Another manner of uncoupling respiration is by using small …
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The use of a genetic strategy to study the role of modulation of oxidative stress by uncoupling proteins 2 and 3 in the pathogenesis of Type 2 Diabetes
… the early pathogenesis of Type 2 Diabetes. The uncoupling proteins 2 and 3 are mitochondrial proteins found in man that have been implicated in protecting mammals from the effects of over-nutrition. Examination of the effect of genetic variation in the UCP2-UCP3 genetic cluster has so far been …
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Complex Heterocycles as Mitochondrial Uncouplers
… increased energy expenditure. Mild mitochondrial uncoupling has therapeutic potential in treating obesity, diabetes, neurological diseases, non-alcoholic steatohepatitis (NASH), and aging. Our group has previously reported the discovery of a small molecule mitochondrial uncoupler BAM15, which was …
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The Role of UCP2 in Pancreatic Cancer Metabolism and Its Potential as a Radiosensitizer
<p>Uncoupling protein 2 (UCP2) is a mitochondrial protein that regulates the flow of protons down the gradient established by the electron transport chain (ETC) without generating ATP, thus uncoupling the proton gradient from ATP generation. In tumors, specifically pancreatic cancer (PDAC), the ETC …
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Investigating the Functional Response of a Subsurface Biofilm Community to Xenobiotic Stress
… elicit two responses, oxidative phosphorylation uncoupling and GGKE, that appeared to be concentration dependent. Oxidative uncoupling was the controlling metabolic response up to 10 mg/L PCP, while the GGKE stress response was activated near 20 mg/L PCP. PCP column biomass did not show long-term …
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Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy
… ADP phosphorylation) in the RV while promoting uncoupling of mitochondrial oxidative phosphorylation (increased state 4 respiration and basal leak) in the LV.
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