Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Unc-52."”.
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Genetic and molecular analysis of mutations in the unc-52 gene of Caenorhabditis elegans, and isolation of a suppressor, sup-38
Mutations in the unc-52 gene in Caenorhabditis elegans have been grouped into four categories based on their mutant phenotypes and complementation patterns. Class 1 mutations result in gradual paralysis beginning in the late larval stages or early in adulthood. Animals homozygous for these alleles …
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Role of SMU Homologues in Pre-mRNA Splicing During Maize and Arabidopsis Development
… a genesimilar to the smu-2 (suppressor of mec-8 unc-52) gene in nematodes. Previous studies showed that the mutations in either thenematode smu-1 or smu-2 genes affect splicing of the unc-52 pre-mRNA, and SMU-1 protein interacts with SMU-2 protein. In addition, human homologues of SMU-1 and SMU-2 …
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The extracellular matrix of the nematode Caenorhabditis elegans : a model to study the role of cell-matrix interaction in animal development.
… important role in tissue formation. I focused on UNC-52/perlecan, a proteoglycan ECM molecule, because it contains two RGD (Arg-Gly-Asp) motifs in their domains. The mutations in two RGD motifs showed that the removal of a motif in RGD2023 position resulted in embryonic lethality, while a point …
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Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans
… essential for viability, although their exact function is still unclear. In <em>Caenorhabditis elegans</em> only one ortholog of <em>APP</em> is present, <em>apl-1</em>. Similar to <em>APP</em> family members, <em>apl-1</em> is essential for viability; APL-1 is cleaved and releases an …
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New Insights into the Regulatory Network Controlling Neuroblast Migration in C. elegans
… Proper migration of neurons leads to proper function while incorrect migrations can lead to neurodevelopmental disorders such as epilepsy and mental retardation. Therefore it is worthwhile to study the genetic mechanisms that control migrating neuroblasts.The model organism Caenorhabditis …