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Showing 1 to 20 of 43 for “"Umbilical cord blood"”.
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Pitfalls in Interpreting Umbilical Cord Blood Gases and Lactate at Birth
Acid-base status in umbilical cord blood is an objective measure of the fetus’ exposure to and ability to handle hypoxia. The objective of this thesis was to clarify some of the methodological pitfalls in interpreting umbilical cord blood gases and lactate values at birth. Study I pinpoints the …
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Signaling pathways regulating self-renewal, differentiation, and multipotency of CD133+ umbilical cord blood stem cells
Our goal is to increase the number of immature umbilical cord blood stem cells (UCBSCs) for hematopoietic transplantation. Towards this goal, our lab adapted a culture technique to grow immature CD133+ UCBSCs (CD133+ cells). Although CD133+ cells proliferate rapidly in culture, a minority …
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Development of a novel approach to expand umbilical cord blood-derived haematopoietic stem/progenitor cells ex vivo for clinical transplantation
Umbilical cord blood (UCB) is a well established alternative source of haematopoietic stem/progenitor cells (HSPC) for haematopoietic stem cell transplantation (HSCT). One factor limiting the wider use of UCB for transplantation is the relatively low cell dose from a UCB unit compared to bone …
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Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
Introduction: Malignant Melanoma (MM), caused by UV radiation-induced DNA damage, is the most invasive form of skin cancer and has an increasing incidence worldwide. The hallmarks of MM include the presence of reactive oxygen species (ROS) and excessive proliferation of tumour cells. Many …
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Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
Introduction: Malignant Melanoma (MM), caused by UV radiation-induced DNA damage, is the most invasive form of skin cancer and has an increasing incidence worldwide. The hallmarks of MM include the presence of reactive oxygen species (ROS) and excessive proliferation of tumour cells. Many …
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Isolation of Mesenchymal Stem Cells Derived from Adult Bone Marrow and Umbilical Cord Blood and Their Potential to Differentiate into Osteoblasts
… stem cells from both adult bone marrow and umbilical cord blood using a novel isolation method based on immunodepletion. Furthermore we will look at the potential of these isolated MSCs to differentiate into mature, bone producing osteoblasts. The results of the studies showed that our novel …
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Evaluation of Anti-cancer effect of a Novel Formulation from Umbilical Cord Blood Stem CellDerived Exosomes and Retinoic acid as a potential therapeutic candidate against Malignant Melanoma
… safety profiles, i.e., Retinoic acid (RA) and Umbilical cord blood stem cell (CBSC)-derived exosomes as an anti-cancer drug. The current in vitro study has evaluated the genotoxicity and cytotoxicity of RA and CBSC-derived exosomes, either alone or combined, on lymphocytes from healthy …
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Cord Blood Collection in Pregnant Women for Stem Cell Research
Umbilical cord blood (UCB) stem cells form commonly banked types of human tissue. Confusion remains about sources of stem cells and their use. Birth is a once in a lifetime opportunity with 74 million births per year in the world and four million occur in the United States. Cord blood contains …
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Multi-Scale Osteointegration and Neovascularization of Biphasic Calcium Phosphate Bone Scaffolds
… scaffold mechanical properties and (2) human umbilical cord blood-derived endothelial colony forming cells have potential for promoting neovascularization in a bone defect when combined with rhBMP-2.
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Ex Vivo Expanded Cord Blood Natural Killer Cells As A Novel Therapeutic For Multiple Myeloma
… malignancies and may have a role against MM. Umbilical cord blood is a potential source for allogeneic NK cells and <em>ex vivo</em> expanded umbilical cord blood-derived NK (CB-NK) cells demonstrate activity comparable to that of peripheral blood-derived NK cells. However, large-scale …
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Deconvolution of Leukemic Evolution Through Initiation, Progression and Relapse
… answering these questions. Using primary human umbilical cord blood cells, transduced with leukemic variants in a xenograft assay, we uncovered the importance of novel transcriptional programs, including induced stem cell transcriptional programs, in leukemogenic transformation. Recent evidence …
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The Roles of Krüppel-Like Factor 1 (KLF1) in the Human Fetal Erythroid Compartment.
… knockdown in in vitro-differentiated CD34+ human umbilical cord blood cells. -globin expression appears dependent on KLF1; it is increased with modest KLF1 knockdown but not in cells with low KLF1. KLF2 mRNA amounts are usually increased in KLF1 knockdown. KLF1 knockdown in CD34+ cells results in …
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Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity
… as a novel treatment strategy for diabetes. Umbilical cord blood (UCB)-derived hematopoietic stem/progenitor cells (HSPC) isolated by high aldehyde dehydrogenase activity (ALDHhi) reduce hyperglycemia after transplantation into streptozotocin (STZ)-treated NOD/SCID mice. However, UCB-derived …
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Ice Recrystallization Inhibition as a Mechanism for Reducing Cryopreservation Injury in a Hematopoietic Stem Cell Model
… inhibition used in the cryopreservation of umbilical cord blood and recovery of viable non-apoptotic cells and hematopoietic progenitor function. Furthermore, increased numbers of apoptotic cells in hematopoeitic stem cell grafts were associated with reduced hematopoietic function and …
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Microbial, metabolic and molecular determinants of neonatal mortality in the rural areas of Limpopo Province, South Africa: umblical cord blood metabolomic profile and bacterial anaysis and their association with perinatal complications
… test profiling) and metabolomic profiling of umbilical cord blood to identify potential biomarkers for perinatal complications. METHODS: A cross-sectional study utilizing purposive sampling was conducted at selected district hospitals in the Vhembe district from May 2023 to September 2023. …
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Cell separation and cryopreservation of cord blood fractions for immunotherapeutic applications
… 2008 Anthony Nolan opened the UK’s first public umbilical cord blood (CB) bank (Anthony Nolan Cell Therapy Centre, ANCTC) in which CB is stored for haematopoietic stem cell (HSC) transplantation. Due to strict quality thresholds, the majority of units are not suitable for transplantation. …
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A Tissue-Engineered Microvascular System to Evaluate Vascular Progenitor Cells for Angiogenic Therapies
… following hypotheses: (1) cocultures of human umbilical cord blood-derived endothelial progenitor cells (hCB-EPCs) with mural cells can produce the microenvironmental cues necessary to support physiological microvessel formation in vitro; (2) poly(ethylene glycol) (PEG) hydrogel systems can …
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Exploration of biological causes of psychological problems in polycystic ovary syndrome (PCOS)
… Results: 1/ Elevated T was found in the umbilical cord blood of the female fetus in PCOS pregnancies; 2/ Mood problems in PCOS were not directly caused by T. 3/ Women with PCOS showed higher levels of mood problems typical of hypoglycaemia than controls. Conclusions: The findings suggest …
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