Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"Umbilical Cord"”.
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Newborn Umbilical Cord Care: An Evidence Based Quality Improvement Project
<p>No Abstract Available</p>
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Pitfalls in Interpreting Umbilical Cord Blood Gases and Lactate at Birth
Acid-base status in umbilical cord blood is an objective measure of the fetus’ exposure to and ability to handle hypoxia. The objective of this thesis was to clarify some of the methodological pitfalls in interpreting umbilical cord blood gases and lactate values at birth. Study I pinpoints the …
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Tissue Engineering the TMJ Condyle using Human Umbilical Cord Mesenchymal Stromal Cells
… pathologies. Prior to this thesis, human umbilical cord mesenchymal stromal cells (hUCMSCs), identified as multipotent cells only in this decade, had not yet been used for TMJ tissue engineering. Hence, this thesis proposed a revolutionary tissue engineering approach in which hUCMSCs and …
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INVESTIGATIONS ON POTENTIAL OF UMBILICAL CORD LINING STEM CELLS FOR IN VITRO MODELS
… therapy. In our study, the potential of human umbilical cord lining stem cells (UCLSCs) for in vitro models is investigated in two broad directions. Using a patented explantation method, umbilical cord lining mesenchymal cells (UCLMCs) are isolated and subjected to adipogenesis under varying …
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COMPARISON OF EQUINE BONE MARROW-, UMBILICAL CORD MATRIX-, AMNIOTIC FLUID- AND TENDON-DERIVED PROGENITOR CELLS
… there may be a stem cell population within both umbilical cord matrix and amniotic fluid. However, little knowledge exists about the characteristics of these progenitor cells within these sources in the equine species. This study wanted to investigate an alternative and non-invasive stem cell …
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Signaling pathways regulating self-renewal, differentiation, and multipotency of CD133+ umbilical cord blood stem cells
Our goal is to increase the number of immature umbilical cord blood stem cells (UCBSCs) for hematopoietic transplantation. Towards this goal, our lab adapted a culture technique to grow immature CD133+ UCBSCs (CD133+ cells). Although CD133+ cells proliferate rapidly in culture, a minority …
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Adenoviral Mediated Gene Delivery to Human Umbilical Cord Mesenchymal Stromal Cells for Inner Ear Hair Cell Differentiation
… thesis was to evaluate the potential of human umbilical cord mesenchymal stromal cells (hUCMSCs) as a possible source for regenerating inner ear hair cells. This thesis was successful in developing an adenoviral mediated gene delivery approach to deliver the Math1 gene to hUCMSCs. The …
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Immunological Characterization of Human Umbilical Cord Lining Derived Cells and their Therapeutic Application in a Diabetic Mouse Model
… primary epithelial cell-type from the human umbilical cord. Two types of cells can be derived from the umbilical cord lining membrane, termed cord lining epithelial cells (CLECs) and cord lining mesenchymal cells (CLMCs). Preliminary immunophenotyping showed that CLECs but not CLMCs express …
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Conversion of equine umbilical cord matrix mesenchymal stem cells to the trophectoderm lineage using the Yamanaka reprogramming factors
… challenges in equine regenerative medicine. Umbilical cord matrix mesenchymal stromal cells (MSC) were transduced with the non-integrating Sendai virus encoding for the OSKM transcription factors. The cells initially were cultured on mouse embryonic feeder cells supplemented with LIF (10 …
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The use of a neural network to recognize placental insufficiency from blood flow velocity waveforms in the umbilical cord
… decision-making is based on measuring the umbilical arterial blood flow velocity waveforms from one site of the cord. There is an ongoing debate on the predictive value of Doppler measurements in the evaluation of the foetal condition. The aim of this thesis is to investigate the use ofa …
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Brain Injury and Inflammation and Placental Inflammation in Response to Repetitive Umbilical Cord Occlusions in the Near Term Ovine Fetus
We hypothesized that repetitive umbilical cord occlusions (UCOs) leading to severe acidemia will stimulate a placental and fetal inflammatory response associated with brain injury, which will be exacerbated by chronic hypoxemia and low-grade infection. Chronically instrumented fetal sheep served as …
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The effects of magnetic field (MFs) on in vitro culture of human umbilical cord derived mesenchymal stem cells (hUC-MSCs)
… the proliferation rate of stem cells. Accordingly, this current study aims to investigate the potential impact of induced Static Magnetic Field (SMF) on human Umbilical Cord-Derived Mesenchymal Stem Cells (hUC-MSCs) using Samarium Cobalt (SmCo5). SmCo5 was selected for the study due to …
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Development of a novel approach to expand umbilical cord blood-derived haematopoietic stem/progenitor cells ex vivo for clinical transplantation
Umbilical cord blood (UCB) is a well established alternative source of haematopoietic stem/progenitor cells (HSPC) for haematopoietic stem cell transplantation (HSCT). One factor limiting the wider use of UCB for transplantation is the relatively low cell dose from a UCB unit compared to bone …
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Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
Introduction: Malignant Melanoma (MM), caused by UV radiation-induced DNA damage, is the most invasive form of skin cancer and has an increasing incidence worldwide. The hallmarks of MM include the presence of reactive oxygen species (ROS) and excessive proliferation of tumour cells. Many …
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Investigation of a Novel Formulation from Umbilical Cord Blood Stem Cell-Derived Exosomes and Antioxidant (Selenium) in Malignant Melanoma Cells
Introduction: Malignant Melanoma (MM), caused by UV radiation-induced DNA damage, is the most invasive form of skin cancer and has an increasing incidence worldwide. The hallmarks of MM include the presence of reactive oxygen species (ROS) and excessive proliferation of tumour cells. Many …
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Isolation of Mesenchymal Stem Cells Derived from Adult Bone Marrow and Umbilical Cord Blood and Their Potential to Differentiate into Osteoblasts
… stem cells from both adult bone marrow and umbilical cord blood using a novel isolation method based on immunodepletion. Furthermore we will look at the potential of these isolated MSCs to differentiate into mature, bone producing osteoblasts. The results of the studies showed that our novel …
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Home-based care for umblical cords neonates by family caregivers at Waterval Community in Mpumalanga Province
There is still a rise in neonatal umbilical cord sepsis despite the recommendations made by the World Health Organisation on umbilical cord care, adopted by most countries, including South Africa in 2014. The study aimed to explore and describe home-based care of neonates’ umbilical cords by family …
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Cord Blood Collection in Pregnant Women for Stem Cell Research
Umbilical cord blood (UCB) stem cells form commonly banked types of human tissue. Confusion remains about sources of stem cells and their use. Birth is a once in a lifetime opportunity with 74 million births per year in the world and four million occur in the United States. Cord blood contains …
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