Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Ultraconserved Elements"”.
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Mutational Landscape of Noncoding Ultraconserved Elements in Human Cancers: Functional Relevance and Clinical Utility
<p>The mutational landscape of phylogenetically ultraconserved elements (UCEs), especially those in noncoding DNA regions (ncUCEs), and their functional and clinical relevance in cancers remain poorly characterized. In this thesis, we perform a systematic analysis of whole-genome sequencing (WGS) …
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Harnessing Cancer Omics to Inform Precision Oncology
… mining based on natural language. We identified ultraconserved elements (UCE) that can be enhancers of tumor suppressor and silencers of oncogene in colon cancer via whole genome and targeted UCE sequencing from two cohorts. We characterized the tumor microenvironment of melanoma brain metastasis …
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Pseudoscorpion Systematics & Phylogenetics: Exploring the Effects of Accelerated Rates of Evolution on Both Ancient and Recent Diversification
… phylogenomic analysis for the order, using ultraconserved elements (UCEs) to infer evolutionary relationships between chthoniid lineages and estimate divergence times using Bayesian inference and fossil calibrations. In Chapter 2, I zoom in on one subset of the chthoniid phylogeny, …
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Evolution of the aquatic beetle family Noteridae (Coleoptera: Adephaga): integrating methods to examine patterns of diversification across temporal scales.
… the first phylogenomic study of Adephaga with ultraconserved elements (UCEs). UCEs are captured by targeted, probe-based, enrichment and subsequent next-gen sequencing, and are known for effective phylogenetic reconstructions at both deep and shallow time scales. Capturing over 300 loci, we …
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Assessing the information content of fossilizable data, with a focus on the Asian origin and diversification of Glires (Mammalia)
My thesis explores how the information content of fossil Glires (rodents + rabbits) effects phylogenetic reconstruction and the implications for downstream analysis and interpretation. The first two chapters take a detailed look at the phylogenetic signal contained within fossil Glires, while the …