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Showing 1 to 5 of 5 for “"Ultra-high dose rate"”.
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Pre-clinical evaluation of lethal and sublethal DNA damage in human cell cultures by ultrashort pulse and ultra-high dose rate laser accelerated protons
… brain and heart. Numerous studies have demonstrated the feasibility of using high LET particles in tumor cells; however, the very high installation and operational costs limit the utilization of particle therapy.<br/><br/>The idea of future facilities based on laser-driven ion accelerators has …
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The Role of UCP2 in Pancreatic Cancer Metabolism and Its Potential as a Radiosensitizer
… pancreatic cancer (PDAC), the ETC is highly stimulated to generate the copious ATP needed by the tumor to grow. However, extended ETC use increases reactive oxygen species (ROS), and if left unchecked, results in cell death. To evade this, PDAC employs antioxidant strategies, including …
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Ion dosimetry for radiobiology experiments employing laser-accelerated beams
Cell behaviour in ultra-high dose rate environments, characteristic of laser driven ion acceleration, is a largely unexplored field of research, the understanding of which is crucial to the development of an all-optical delivery of ion beams suitable for cancer treatment. In conducting cell …
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Facilitating the Clinical Translation of Flash Radiotherapy Through Dosimetry Development and Beam Parameter Optimization
… complications<sup>1</sup>. Recently, ultra-high dose-rate (UHDR) RT (mean dose rates ≥40 Gy/s for a total duration of ≤200 ms) has been reported to selectively spare normal tissues and organs while maintaining an isoeffective tumoricidal effect compared to conventional (CONV) dose rate …
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Radiation biophysical modeling of the FLASH effect: from mechanistic understanding towards clinical endpoint prediction
Background Ultra-High Dose Rate (UHDR) or, commonly, FLASH irradiation is a novel dose-delivery technique based on fast beam release, with typically a total irradiation time < 100 ms and a total mean dose rate > 40 Gy/s for a single dose, usually higher than 10 Gy. Experimentally, compared to …