Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Ultra High Performance Liquid Chromatography"”.
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Development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods for screening of selective androgen receptor modulators in urine and blood
… significant advancements in the analytical performance of antidoping testing and established a deep knowledge of steroid profiles in humans, athletes continue to cheat and exploit the properties of emerging novel anabolic drug enhancers namely selective androgen receptor modulators (SARMs). …
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The Development and Validation of a Quantitative Mass Spectrometric Method for the Analysis of Polypeptides in Human Plasma
… as solid phase extraction in conjunction with ultra-high performance liquid chromatography. Methods to improve the limit of detection of AVP have been performed, utilising mass spectrometry. High field asymmetric ion mobility has been trialed to assess if the interface gave benefits. The limit …
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METHOD DEVELOPMENT OF STANDARD DILUTION ANALYSIS ON MOLECULES AND DISSOLUTION STUDIES OF IBUPROFEN TABLETS ALONG WITH COMMON BEVERAGE CONSTITUENTS
… elements called standard dilution analysis. This high-risk, high reward attempt used the newly developed standard dilution analysis on complex molecules and Ultra-High-Performance Liquid Chromatography and produced errors from 11% to 15% that were attributed to pump pressure ripples. Biphenyl was …
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Studies of UHPLC-MS performance and application to rapid sensitive and robust drug analysis
This thesis comprises studies of ultra high performance liquid chromatography (UHPLC) performance with a particular focus on the application of liquid chromatography-mass spectrometry (LC-MS) for the analysis of basic drugs. UHPLC-MS technologies are investigated to facilitate fast, sensitive and …
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Adsorption of Organic Pollutants onto Microplastics
… of EtP and BP-3 onto PE MPs was analyzed using ultra-high performance liquid chromatography (UHPLC). The UHPLC parameters and figures of merit for EtP and BP-3 were established. The adsorption experiments used size of MPs, weathering of MPs, and time as the experimental variables. Pristine small …
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Development of an LC-MS/MS method for the analysis of triacylglycerols from meat and application in the discrimination of cooked meat products
A single stage reversed phase high performance liquid chromatography (RP HPLC) separation of animal fat triacylglycerols (TAGs) has been developed for coupling with atmospheric pressure chemical ionization tandem mass spectrometry using an ion trap mass spectrometer. The method developed offers …
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Pharmacocinétique comparative des curcuminoïdes avec ou sans oméga-3 : une étude en chassé-croisé randomisée
… of 7 days. Plasma samples were analyzed by ultra high-performance liquid chromatography with a triple quadrupole mass spectrometer (UPLC-MS/MS). Participants mean age was 27.6 ± 6.0 years old and they had an average body mass index of 25.1 ± 3.8 kg/m2. Twenty-four hours after a single dose …
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Development and Application of Rapid Methods for the Analysis of Selected Pollutants in Environmental Aquatic Matrices
… industrial and semi-rural areas.<br/><br/>Ultra High Performance Liquid Chromatography (UPLC) and Tandem Mass Spectrometry with electrospray ionisation as an interface was used to establish the optimal chromatographic separation and detection parameters for analytes. The data was evaluated …
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Assessment of road pollutants in roadside retention ponds.
… the aquatic environment. A direct injection ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated to analyse 25 additive chemicals in environmental samples. Method quantification limits (MQLs) ranged from 4.3 × 10-3 – 13 μg/L …
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Diel patterns of insect herbivory and plant secondary metabolites in understory shrubs on Barro Colorado Island
… species during daytime and nighttime hours using ultra high-performance liquid chromatography (UHPLC), electrospray ionization and molecular fragmentation, and tandem mass spectrometry (MS/MS). Network analyses show that plant secondary metabolites varied greatly in their presence in leaves over …
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Diterpenes as models for the study of their effect on neural progenitor cells and on cytochrome p-450 enzymes
… for identification of Euphorbia component. A Ultra-High performance liquid chromatography coupled with high resolution mass spectrometry (UHPLC/HRMS) based targeted and untargeted identification workflow using MSE data-independent acquisition tandem mass spectrometry was developed to analyze …
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The Gut Mucosal Microbiome of HIV- exposed Uninfected Infants in Africa
… Africa has a large HIV disease burden, with the highest rate of infection occurring in young women of the childbearing age. This gave impetus to the Prevention-of-Mother-To-Child-Transmission (PMTCT) program, that has been successfully implemented. Due to the success of the PMTCT program, …
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Performance of septic tanks for pharmaceutical removal and their impact to river water quality.
… the aim of this research was to understand the performance of STs for pharmaceutical removal and their impact to river water quality. A methodology for the analysis of 68 pharmaceuticals, including prescription and over-the-counter drugs, related metabolites, hormones, and other human wastewater …
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In vitro evaluation of the enzyme inhibition and membrane permeation properties of benzophenones extracted from honeybush
… experiments were analysed by means of ultra-high performance liquid chromatography (UHPLC). The crude extract ARC188 has presented with better inhibition against the rat α-glucosidase and pig lipase enzymes (IC50 = 150 μg/ml and IC50 = 198 μg/ml, respectively) than the crude extract …
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Effects of malting and dehulling on the functional structural antioxidant properties of Bambara Groundnut (Vigna Subterranean) flour
… metabolomic profiles were evaluated using Gas Chromatography Tandem Mass Spectrometry and Ultra-High Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. Malting significantly (p < 0.05) enhanced the water absorption capacity of BGN flours, with cream and red varieties …
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An investigation of the association between structural proteins and lipids with scalp hair curvature
… whereby African hair generally incorporated higher drug levels than Asian and Caucasian hair types. It was hypothesized that higher absolute lipid amounts in African curly hair may affect the rate at which lipid-soluble metabolites are passively incorporated into the growing hair shaft. …
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Emerging anabolic drugs - investigation of the in vitro and in vivo metabolism of selective androgen receptor modulators
… generate phase I and II metabolites followed by ultra-high performance liquid chromatography- quadrupole time of flight mass spectrometry (UHPLC-QTOF MS) analysis. All fractions produced metabolites that have previously been described as important target analytes of the investigated SARM …