Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Ulcerative colitis (UC)"”.
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Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity
… study was to determine which symptom domains in ulcerative colitis (UC) are important in the evaluation of disease activity. An important symptom is that which 1) occurs during flares, 2) improves during effective therapy, and 3) resolves during remission. Twenty eight symptom domains were …
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Evaluation of pediatric acute ulcerative colitis management protocol
<p>Pediatric patients with ulcerative colitis (UC) represent a high-risk population with severe disease that requires hospitalization. This study evaluates the impact of implementing an acute UC management protocol on 39 pediatric patients. After analysis, significant trends were shown for admitted …
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Complex Evaluation of the Effectiveness of Biological Therapy in Patients with Active Ulcerative Colitis // Комплексна оценка на ефективността от биологична терапия при болни с активен язвен колит
Inflammatory bowel diseases (IBD), namely ulcerative colitis (UC) and Crohn's disease (CD), are chronic immune-mediated conditions with a high incidence in developed countries and a rapidly increasing incidence in highly industrialized countries. The pathogenesis of UC is complex and still unclear. …
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DNA alkylation repair deficient mice are susceptible to chemically induced Inflammatory Bowel Disease
… forms of inflammatory bowel disease (IBD) are ulcerative colitis (UC) and Crohn's Disease (CD), which affect more than 1 million Americans. Recently the incidence of IBD has been rising in Japan, Europe and North America.' Colorectal cancer is a very serious complication of IBD, and a patient's …
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Geographic Differences in the Risk of Surgery in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis
Crohn’s disease (CD) and ulcerative colitis (UC), collectively known as the inflammatory bowel diseases (IBD), are chronic immune mediated conditions. The pathophysiology of these disease is not well understood but genetic predisposition, dietary and microbiome-related factors, and environment …
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Immunological responses following surgery in ulcerative colitis
… soluble adhesion molecules, plasma and mucosal cytokines were studied following surgery for ulcerative colitis (UC). A high prevalence of ANCA was found in UC but not in Crohn’s disease. ANCA positive UC sera were found to recognise a variety of antigens, namely lactoferrin, cathepsin G, …
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The Role of Transforming Growth Factor Beta Signaling in Inflammation-Dependent Colon Cancer
Chronic inflammatory conditions such as Crohn's disease (CD) and Ulcerative colitis (UC) are risk factors for colon cancer. TGFβ has been shown to be dysregulated in colon cancer. Bacteria-induced inflammation is necessary for the induction of colon cancer in TGFβ mouse models. However, the …
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Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis
Ulcerative colitis (UC) is a heterogeneous inflammatory bowel disease (IBD) associated with chronic inflammation of the gastrointestinal tract. Characterized by genetic and immunological abnormalities, UC has overly aggressive T-cell responses to commensal bacteria eventually leading to disease …
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Elucidating the biology of G-protein coupled receptor 35
… to primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). GPR35 is also upregulated in numerous cancers. Multiple studies of GPR35 have so far fallen short of revealing its core biology. In this project we set out to gain further understanding of the biology of GPR35. Starting with …
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Effect of Coconut Oil on Ulcerative Colitis in the Mouse Model
<p>Ulcerative colitis (UC) is a chronic disease of the colon or large intestine that causes inflammation and ulceration of the inner lining of the colon and rectum. In patients with ulcerative colitis, the body’s immune system overreacts and the body mistakes food, bacteria or other internal …
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The mucosal microbiome of inflammatory bowel diseases
… this and other cutting edge techniques to elucidate the mucosal associated microbiome in Inflammatory Bowel Disease and finally examines the viability of using mucosal samples for shotgun metagenomics or metatranscriptomics. Taxonomic classification is a corner stone for the characterisation …
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Efeito do consumo de iogurte caprino probiótico no perfil bioquímico e histopatológico de ratos
… a matrix suitable for inclusion of ingredients such as honey, which is an important food not only for its nutritional properties, but also by their functional and biological properties are mainly attributed to the presence of phenolic compounds and flavonoids. Inflammatory Bowel Disease (IBD) …
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The effect of oxidative stress in lymphocytes from patients with inflammatory bowel disease and various cancer states compared with healthy control individuals.
… (CD) were found to have higher responses than Ulcerative colitis (UC) patients. The responses for all IBD and HCI were all reduced in the presence of chaga mushroom extract which behaved in an antioxidant manner. A second group of IBD patients were treated with the heterocyclic amine (food …
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The effect of oxidative stress in lymphocytes from patients with inflammatory bowel disease and various cancer states compared with healthy control individuals.
… (CD) were found to have higher responses than Ulcerative colitis (UC) patients. The responses for all IBD and HCI were all reduced in the presence of chaga mushroom extract which behaved in an antioxidant manner. A second group of IBD patients were treated with the heterocyclic amine (food …
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Testing the Anti-Inflammatory Effects of Dietary Phytochemicals in Intestinal Inflammation Models
Ulcerative colitis (UC) is an immune-mediated chronic disease characterized by colonic inflammation, ulcers and erosion. Medications benefit 50% UC patients and have serious adverse effects. Therefore, safe and efficient molecules are needed as stan-alone drugs or in combination with available …
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Disruption of Immunoregulatory Functions of Intestinal Mesenchymal Stromal Cells and their Progenitors in Inflammatory Bowel Disease
Crohn’s Disease (CD) and Ulcerative Colitis (UC), the two major forms of Inflammatory Bowel Disease (IBD), are multifactorial autoimmune diseases caused by an abnormal immune response to gut microbiota in genetically susceptible individuals resulting in dysregulation of type 1/2/17 immune …
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Applications of LC-MS metabolomic profiling in inflammatory bowel disease and the development of derivatisation methods to enhance selective detection of certain compound classes
… and is represented by two major variations, ulcerative colitis (UC) and Crohn's disease (CD). It is diagnosed based on the pattern of inflammation. In order to understand the pathology of the disease better urine and saliva samples were collected from patients with IBD, patients in remission …
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Ethnic Variations of Pediatric Inflammatory Bowel Disease Within Canada
… IBD Network (CIDsCaNN) inception cohort was conducted. Children were categorized into eight different ethnic groups using a modified Statistics Canada classification method. Baseline data such as demographic characteristics, disease phenotype and activity, family history of IBD, surgeries, and …
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Sulfate -Reducing Bacteria and Their Contribution to Intestinal Epithelial Disorders
Ulcerative colitis (UC) and colon cancer are complex and enigmatic diseases, thought to originate from a similar interplay between genetic predisposition and environmental insults. Intestinal hydrogen sulfide (H2S), produced by commensal sulfate-reducing bacteria (SRB), may represent such an …
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Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors
Tolerance is crucial for maintaining immunological balance and avoid autoimmune diseases like type 1 diabetes and the inflammatory bowel disease, ulcerative colitis (UC). In Study I, we have investigated the regulatory role of a class of noncoding RNAs, the miRNAs, during thymocyte development of …
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