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Showing 1 to 4 of 4 for “"Ugi reaction"”.
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Harnessing cheminformatics for catalyst design I. Investigation into a general, asymmetric synthesis of cinchona alkaloid analogs towards asymmetric phase transfer II. Development of an enantioselective brønsted acid catalyzed four-component Ugi reaction
… phase transfer catalyzed cyclopropanation reaction. Second, (R)-BINOL derived phosphoric acids were studied in regards to the brønsted acid catalyzed Ugi reaction. In regards to Cinchona alkaloids, the concentration was first on methodology develop to rapidly synthesize diverse …
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Development of stapled peptide targeted covalent inhibitors and synthesis of novel ADC payloads for applications in cancer therapy
… was achieved, through a four-component Ugi reaction, in total 14 steps (longest linear sequence of 10 steps) in 11% overall yield. The convergent synthetic route also enabled the synthesis of taltobulin (HTI-286), a similarly potent synthetic analogue. Through the synthesis of complex …
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Biological Evaluation Of The Vaccine Candidate Tf-Ps A1 And A One-Pot Multicomponent Coupling/cyclization For Natural Product Herbicide (±)-Thaxtomin A
… one-pot procedure with a 32% isolated yield. The Ugi reaction was utilized with 4-nitroindolylacetaldehyde, methylamine, 3-hydroxyphenylpyruvic acid, and methyl isocyanide to prepare in situ a dipeptide intermediate which then underwent an alkaline mediated keto-amide cyclization to provide TA and …
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Kinetic modeling and automated optimization in microreactor systems
… kinetic investigation, or scale-up of a reaction often requires significant time and materials. Silicon microreactor systems have been shown advantageous for studying chemical reactions due to their small volume, rapid mixing, tight temperature control, large range of operating …