Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Ugi"”.
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Arilglioxales en reacciones Passerini y Ugi. Síntesis de heterociclos
… “Tautomería cetoenólica en aductos Passerini y Ugi”, se hace un estudio de la tautomería y reactividad de las β-cetoamidas obtenidas en reacciones Passerini y Ugi utilizando arilglioxales como reactivos de partida, equilibrio que se ha estudiado desde el punto de vista teórico y experimental. …
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Síntesis de sistemas heterocíclicos nitrogenados en secuencias Ugi/ciclación a partir de glioxales y ácidos haloacéticos
… como reactivos de partida en la reacción de Ugi ha demostrado ser una poderosa herramienta en la construcción de sistemas heterocíclicos nitrogenados. Por un lado, al utilizar el ácido cloroacético combinado con aminas con H-α ácidos como reactivos de partida se han obtenido 2-azetidinonas, …
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Endoscopic Incidence of Upper Gastrointestinal Submucosal Tumors and Endosonographic Findings
… But recently, the upper gastrointestinal(UGI) endoscopy has been frequently performed for the purpose of routine health check-ups and the trend of detecting SMTs has been increased, but no study has been conducted on the incidence rate. So, the authors investigated the endoscopic incidence …
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Synergies and Trade-offs in Urban Green Infrastructure
Urban Green Infrastructure (UGI) is increasingly integrated into urban planning to tackle climate change, biodiversity loss, and public health challenges. Its multifunctionality and ability to deliver multiple Ecosystem Services (ESs) make UGI a "win-win" nature-based solution. Yet, focusing only …
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Synergies and Trade-offs in Urban Green Infrastructure
Urban Green Infrastructure (UGI) is increasingly integrated into urban planning to tackle climate change, biodiversity loss, and public health challenges. Its multifunctionality and ability to deliver multiple Ecosystem Services (ESs) make UGI a "win-win" nature-based solution. Yet, focusing only …
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Harnessing cheminformatics for catalyst design I. Investigation into a general, asymmetric synthesis of cinchona alkaloid analogs towards asymmetric phase transfer II. Development of an enantioselective brønsted acid catalyzed four-component Ugi reaction
… in regards to the brønsted acid catalyzed Ugi reaction. In regards to Cinchona alkaloids, the concentration was first on methodology develop to rapidly synthesize diverse Cinchona-like analogs in a highly enantioenriched fashion. Systematic examination of the C(9) aryl substitution on …
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The effectiveness of Urban Green Infrastructure for urban heat regulation.
… in this context. Urban Green Infrastructure (UGI) is receiving spotlight attention recently as a mitigation solution for excess heat. UGI provides multiple ecosystem services (ESS) to cities, including excess heat regulation. Cooling potential of UGI is extensively studied in existing …
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The effectiveness of Urban Green Infrastructure for urban heat regulation.
… in this context. Urban Green Infrastructure (UGI) is receiving spotlight attention recently as a mitigation solution for excess heat. UGI provides multiple ecosystem services (ESS) to cities, including excess heat regulation. Cooling potential of UGI is extensively studied in existing …
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Synthese von Peptidmimetika und analoger Verbindungen aus heterocyclischen Iminen
… Strukturen der Peptidmimetika aus. In einer UGI-3-Komponenten-Reaktion gelingt die Darstellung von Mono- und Dithio-bisamiden. Eine modifizierte UGI-SMILES-3-Komponenten-Reaktion mit aromatischen Thiolverbindungen führt zu N-Arylthioamiden. Eine zweistufige Synthese, bestehend aus einer …
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Darstellung unnatürlicher Alpha-Aminosäurederivate durch Additionsreaktionen an acyclische und cyclische Imine
… dargestellt werden können, der Ugi-Reaktion unter Verwendung 'wandelbarer' Isocyanide und der modifizierten Strecker-Reaktion unter Verwendung von Trimethylsilylcyanid. Weiterhin wird eine Eintopfsynthese von vollgeschützten PNA-Monomeren mittels der Ugi-Reaktion vorgestellt. Die …
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Balancing outdoor tourism and recreation development and environmental conservation after major infrastructure improvements: dualling the A9 through Cairngorms National Park.
… geographic information (UGI) from social media and GPS-tracking platforms.<br/>Involving the perspectives of visitors in the National Park, outdoor tourism businesses, and<br/>experts, and comparing these to UGI allowed the exploration of changes from different …
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Antimalarial and cysteine protease inhibitor pharmacophores as scaffolds for new antimalarial agents
… were designed and synthesized using the Ugi 4 component condensation reaction and its variants. The synthesized compounds ranged from simple peptidic molecules to rigid heterocycles.
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Beitrag zur Chemie von Iminen: Synthese und Reaktivitätvon N,X-Heterocyclen (X=N,S)
… wurde 4,9- Dihydro-3H-beta-carbolin im Sinne der Ugi-Reaktion zu totalgeschützten alpha-Aminosäuren umgesetzt. Durch Einsatz chiraler Edukte wurde die Diastereoselektivität der Reaktion überprüft.
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Elaboration of 4′-Phosphopantetheine Adenylyltransferase inhibitors and Benzoxaboroles as antimalarial agents
… (AZ) containing two chemical series, viz. Ugi and cyclohexyl pyrimidine series, was subjected to the medium-throughput screening at the University of Cape Town (UCT)'s Holistic Drug Discovery and Development Centre (H3D). PPAT is a previously unexplored target in P. falciparum, and the …
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Single and hybrid antimalarials based on artemisinin, chloroquine and ß-lactams : synthesis, antiplasmodial activity, cytotoxicity and effect of selected artemisinin-chloroquine hybrids on the parasitic endocytosis pathway
… moiety were synthesized via the Staudinger and Ugi 3-component 4-centre condensation reactions. The compound with the best activity from the series was used to couple these reactions to post-condensation chemical modifications via the Mannich reaction, another multi-component reaction, to create …
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Development of stapled peptide targeted covalent inhibitors and synthesis of novel ADC payloads for applications in cancer therapy
… was achieved, through a four-component Ugi reaction, in total 14 steps (longest linear sequence of 10 steps) in 11% overall yield. The convergent synthetic route also enabled the synthesis of taltobulin (HTI-286), a similarly potent synthetic analogue. Through the synthesis of complex …
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Propuesta de normalización para la representación cartográfica en Internet : Aplicación a los mapas geomorfológicos
… de la Unión Geográfica Internacional (UGI), el método francés, el sistema del IGME y la propuesta de la Sociedad Española de Geomorfología (SEG). De forma complementaria, también se incluyó en este estudio el método alemán. Dada la gran diversidad en contenidos y métodos de …
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Biological Evaluation Of The Vaccine Candidate Tf-Ps A1 And A One-Pot Multicomponent Coupling/cyclization For Natural Product Herbicide (±)-Thaxtomin A
… one-pot procedure with a 32% isolated yield. The Ugi reaction was utilized with 4-nitroindolylacetaldehyde, methylamine, 3-hydroxyphenylpyruvic acid, and methyl isocyanide to prepare in situ a dipeptide intermediate which then underwent an alkaline mediated keto-amide cyclization to provide TA and …
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The design and synthesis of fluorescent peptides and disaccharides for tumour imaging.
… appended chromophores were synthesised via the Ugi four-component condensation reaction. The plan was to discern the most effective energy transfer mediated long-lifetime luminescent combinations, for subsequent attachment to the cyclic peptide as long-lifetime imaging agents which would allow …
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Diverse Applications of Flow Technology in Discovery Chemistry
… was developed. Coupling this method to the Ugi four-component reaction, a series of medicinally relevant amides was synthesized. Reactions performed in the flow system experienced an overall reduction in transformation time from two-days to two-hours and gave yields that were generally …
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