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Showing 1 to 10 of 10 for “"Ubx"”.
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The role of Ultrabithorax negative autoregulation in Drosophila melanogaster
… on the D. melanogaster Hox gene Ultrabithorax (Ubx), I explore how cis-regulatory elements of developmental control genes contribute to these two hallmarks of developmental biology: versatility and robustness. Ubx specifies the identity of the third thoracic (T3) segment along the …
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Investigation of Interactions between Homeodomain Proteins and DNA
… von Bicoid- (Bcd), Ultrabithorax- (Ubx) und Engrailed- (En) Homeodomänen hat gezeigt, dass die Bindung dieser Proteine an doppelsträngige 15 bp Oligonukleotide Veränderungen in der Sruktur der Homeodomänen hervorruft. Diese Veränderungen sind unterschiedlich für Wechselwirkung mit …
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The Cellular And Genetic Mechanisms Underlying Morphological Diversity Of Insects
… the homeotic gene <i>Ultrabithorax (Ubx)</i> is responsible for allometric differences in size between the mid and hind legs. While the embryonic role of <i>Ubx</i> has been well documented, virtually nothing is known about its post-embryonic function in hemimetabolous insects. In the …
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The p97 cofactors UBXN7 and UBXN8 interact with and modulate the function of cullin-RING complexes and Fanconi anaemia proteins FANCD2/FANCI, respectively
… large number of cofactors including the 13 human UBX-domain containing proteins. My PhD projects focused on two of the UBX-domain proteins, UBXN7 and UBXN8.<br/><br/>Among human UBA-UBX proteins, UBXN7 is the most proficient in interacting with CRL (cullin-RING E3 ligase) subunits, in particular …
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Unraveling The Genetic Mechanisms Involved In The Evolution And Development Of The Thoracic Appendages In Insects
… has shown that the homeotic gene Ultrabithorax (Ubx) plays a key role in the enlargement of hind legs not only in orthopterans, but other insect species as well. Another example of a greatly modified hind leg is seen in the honeybee, Apis mellifera, which has been adapted for the collection and …
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Protein quality control in the mammalian endoplasmic reticulum
… proteins are osteosarcoma amplified-9 (OS9), UBX domain containing-8 (UBXD8), Ubiquitinconjugating enzyme-6e (UBC6e), and ancient ubiquitous protein-i (AUP1). Each of these proteins participates in different steps of ER quality control. OS9 directs misfolded soluble glycoproteins to the …
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Characterising the function and evolution of enhancers in Drosophila
… a novel post-embryonic enhancer of the Hox gene Ubx, which provides new insights into how Hox genes are integrated into post-embryonic GRNs that determine fine-scale adult morphology. To help understand the cis-regulatory logic of enhancers, I focussed on a functionally related set of genes in a …
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The role of FOXK transcription factors in Wnt signal transduction
… for transcription factors. Use of a minimal Ubx enhancer system corroborates the function of FOX proteins in general during Wg signalling in the fly. I found that a previously published FoxK fly mutant does not carry a FoxK null allele and consequently generated new knockout alleles using …
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Regulation of sterol regulatory element binding protein-1 in bovine mammary epithelial cells
… by disrupting the interaction between Insig1 and UBX domain-containing protein 8 (Ubxd8), which is part of a degradation complex that removes Insig1 from the ER. In the third study, three potential regulators of SREBP1 activation and their pathways were investigated in insulin, t10, c12-CLA or …
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Appendage development and early Distal-less regulation in arthropods: A study of the chelicerate Tetranychus urticae (Acarida)
… abdominal segments occurs due to powerful Hox (Ubx/AbdA) repression of the early Dll cis-regulatory element; this is discussed in relation to the independently evolved limbless chelicerate opisthosoma, informed by hypothetical scenarios of cis (regulatory DNA) and trans (coding sequence) …