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Showing 1 to 5 of 5 for “"Ubiquitin-like proteins (UBLs)"”.
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The physiological consequences of loss of tRNA thiolation in Saccharomyces cerevisiae
Ubiquitin and ubiquitin-like proteins (UBLs) have a diverse array of functions that serve to regulate many cellular processes in eukaryotic cells. The ubiquitin-related modifier UrmI is a conserved UBL that, in addition to serving as a protein modifier, functions as a sulfur carrier in tRNA …
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Biochemical and Structural Characterization of the Atg8/LC3 Lipidation Pathway
… eukaryotic orthologues LC3 and GARBARAP family proteins (referred here to Atg8 family proteins) play crucial roles in autophagy through their covalent ligation to lipids, typically phosphatidylethanolamine (PE), in a process known as lipidation. Lipidation of Atg8 family proteins regulates …
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Evaluation of drought tolerance in genetically modified Lolium perenne L. and Arabidopsis thaliana
Ubiquitin like proteins (UBLs) are known to have different functions including a potential role in drought tolerance of perennial ryegrass (Lolium perenne L.). UBLs are related in tertiary structure to ubiquitin (UB) and they both serve as regulators of many cellular processes. In previous work …
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Development and Application of Mass Spectrometry Based Methodologies to Study Ubiquitin-Like Modifiers
Ubiquitin-like proteins (UBLs) have broad activities including modification of proteins, lipids, and tRNA. Analysis of both UBL conjugation sites and characterisation of system wide proteome responses is essential to understanding the impact UBLs have on regulating cellular systems. While mass …
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Novel Insights into Ubiquitin-like Protein E1-E2 Interactions
… modification of macromolecules by ubiquitin-like proteins (UBLs) such as ubiquitin, Sumo and NEDD8 regulate a vast array of processes in the cell. Transfer of UBLs to their target generally occurs by a series of molecular handoffs down an E1‑E2‑E3 cascade. We are interested in …