Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Ubiquitin-independent"”.
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Molecular Dissection of the Ubiquitin-Independent Degradation Signal At the Unstructured Amino Terminal End of Human Thymidylate Synthase
… covalent attachment of a small protein called ubiquitin. However, in recent years, several proteasomal substrates have been shown to be degraded efficiently without requirement of this modification, revealing additional yet poorly understood recognition mechanisms, and expanding the possible …
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Substrate Selection by the 20S Proteasome and Implications in Disease Pathogenesis
… by the 20S proteasome in vitro, through a ubiquitin-independent mechanism, are similar to those found in the cingulate cortex of patients with Lewy body diseases. The work presented here describes an investigation into the mechanism by which alpha-synuclein is recognized and degraded by the …
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Interdependent Regulation of Cytomegalovirus Proteins in Complex
… pM141 is degraded in a proteasome-dependent, but ubiquitin-independent pathway. The M141 protein is stabilized by pM140 in a concentration-dependent manner and we identified the region of pM140 required to stabilize pM141. However, direct complexing between pM140 and pM141 is not sufficient to …
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PROTEASOME-DEPENDENT ENTRY OF HERPES SIMPLEX VIRUS
… cells in the absence of a functional host ubiquitin-activating enzyme, suggesting that viral entry is ubiquitin independent. Herpes simplex virus immediate-early protein ICP0 is a multifunctional regulator of herpes simplex virus infection. Late in infection ICP0 interacts dynamically with …
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Metabolism of Alpha-Synuclein by the 20S Proteasome
… that oligomeric forms cause dysfunction of the ubiquitin-proteasome pathway of protein degradation, thereby enhancing an alternative pathway that involves ubiquitin-independent degradation by the 20S core particle of the proteasome. The 20S proteasome is known to degrade proteins with regions of …
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The p97 cofactors UBXN7 and UBXN8 interact with and modulate the function of cullin-RING complexes and Fanconi anaemia proteins FANCD2/FANCI, respectively
… progression, membrane fusion, DNA repair and ubiquitin-dependent protein degradation (including endoplasmic reticulum-associated protein degradation, ERAD). The functional diversity of p97 is achieved by its association with a large number of cofactors including the 13 human UBX-domain …
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Interrogating novel functions of the I kappa B kinases via CRISPR-Cas9 gene editing and small molecule inhibition
… make NEMO a highly effective substrate for ubiquitin-dependent and/or ubiquitin-independent proteasomal degradation. BMS-345541 is a commercially available allosteric inhibitor of IKKβ that has been used extensively in numerous studies, including a report that proposed novel functions for …
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Expression of the repressor element-1 silencing transcription factor (REST) is regulated by IGF-I and PKC in human neuroblastoma cells
… I investigated any possible involvement of the ubiquitin–proteasome system (UPS), a multienzymatic pathway which degrades polyubiquinated soluble cytoplasmic proteins [Pickart and Cohen, 2004]. For this purpose, SH-SY5Y cells are concomitantly exposed to PMA and the proteasome inhibitor MG132. …
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Dynamic relocalization of maternal transcripts during oocyte meiotic maturation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Molecular Mechanisms of Growth Inhibition Mediated by Retinoic Acid in Human Pancreatic Cancer Cells
… studies revealed that the degradation of p21 was ubiquitin-independent, an increase in expression of a novel E3 ligase p53RFP was also seen. Therefore, it can be concluded that (1) p21 can be subject to degradation by several systems, which are independently predominant under particular …