Global ETD Search
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Showing 1 to 10 of 10 for “"Ubiquitin-Protein-Ligase"”.
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Respostas bioquímicas, fisiológicas e moleculares em sementes e plântulas de cenostigma pyramidale após hidratação descontínua
… Dos cincos genes de memória analisados, três (E3 ubiquitin-protein ligase CpRZF1; PYR_PYL_RCAR_like e PRK11107_GAF) foram diferencialmente expressos, revelando insights sobre uma possível memória hídrica na espécie estudada. Em conjunto, nossos dados ressaltam a importância de estudos que visam …
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Characterisation of the EDD gene and its role in cancer.
… EDD is also a multifunctional HECT family E3 ubiquitin protein-ligase, with reported roles in both progesterone action and the DNA damage response. To investigate the possible involvement of EDD in human cancer, several cancer types were analysed for allelic gain or loss (allelic imbalance, …
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Role of PARK2Gene in Maintenance of Pancreatic Beta Cell Functions
… and rs9365294, in the PARK2 gene encoding an E3 ubiquitin-protein ligase (parkin) were significantly associated with fasting plasma glucose levels and insulin secretion indices in response to glucose stimulation in men (3,747 subjects). Replication analysis in two other Korean cohorts and a …
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Electrostatic properties at the interface of p53 Transactivation domain binding
Intrinsically disordered proteins (IDPs) are an abundant class of proteins and protein regions which rapidly change between multiple structures without an equilibrium position. IDPs exist as a series of conformational ensembles of semi-stable conformations that can be adopted based on a hilly …
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The RASSF1A Tumor Suppressor Regulates a Cascade of Oncogenic Signals That Are Restrained by G1 Checkpoint Mechanisms
… G1/S progression through modulation of the ubiquitin ligase SCF-BTrCP. Thus, RASSF1A represents a critical line of defense against tumorigenesis as its loss triggers cell arrest; however, loss of RASSF1A also promotes proliferative signaling events, and additional malfunctions in cell cycle …
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MenzelJohannes_MSc_July_2013
… Complex (APC) is an evolutionarily conserved ubiquitin-protein ligase composed of 13 subunits in yeast, required for M and G1 cell cycle progression, and is associated with cancer and premature aging in many model systems when defective. The APC targets substrates for proteasome-dependent …
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Understanding Host-Pathogen Interactions of Rift Valley Fever Virus That Contribute to Viral Replication
… to replicate. This study identified three host-protein interactors of the viral Gn and L proteins that aid in viral replication. UBR4 was determined to be an interactor of Gn via immunoprecipitation followed by either LC/MS/MS or western blot analysis. Its inhibition via siRNA or CRISPR-Cas9 …
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Kovalente und nicht-kovalente Interaktion ligandengesteuerter Ionenkanäle mit Ubiquitin in Xenopus-laevis-Oozyten
… of modification of cys-loop-receptors by ubiquitination, especially the Glycine-receptor and GABA-receptor. Ubiquitin is a small intracellular protein, which marks other cellular proteins for proteolytic degradation by the proteasome on the one hand and for endocytic elimination from the …
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Untersuchung und Spezifizierung der molekularen Interaktion von Ubiquitin und Sumo mit dem rekombinanten a1-Glyzinrezeptor
… modification by sumoylation and ubiquitination of membrane proteins – in this case of the GlyR alpha 1-subunit and its ubiquitin mediated internalisation – is described. The clinical relevance of those mechanisms is wide spread and would in this case produce an inadequate receptor …
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Building a bridge between biophysics and neurobiology: A synergic approach to develop Alzheimer’s disease translational models and research tools
… and aggregation of the intrinsically disordered proteins amyloid-β (Aβ) and tau, respectively. For decades, these proteins have been the focal point of research efforts and drug discovery initiatives. Recently, the U.S. Food and Drug Administration approved the first three disease-modifying …