Global ETD Search
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Showing 1 to 8 of 8 for “"Ubiquitin-Protein Ligases"”.
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Molecular and Genetic Analysis of Parkin in Microglia Activation and Inflammation-Related Neurodegeneration
… recessive PD. The parkin gene encodes an E3 ubiquitin ligase linked to mitochondrial dysfunction. Most studies on Parkin concentrate on its role in neurons, however, we hypothesize that Parkin function in microglial activation and inflammatory signaling also affect DA neuron survival. Our …
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Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance
… are conserved in all eukaryotes and encode for proteins sharing a common MAGE homology domain. Although only a single MAGE gene exists in lower eukaryotes, the MAGE family rapidly expanded in eutherians and consists of more than 50 highly conserved genes in humans. A subset of MAGEs initially …
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Mechanistic Basis of Signal Amplitude Modulation by the Ras Effector IMP
… Finally, we identify some candidate IMP binding proteins to further investigate how IMP impacts cell behaviors through protein-protein interactions and how IMP is modulated by other proteins.
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Proteasome-Mediated Degradation of PNPLA3
Pages 33-49 are misnumbered as pages 34-50, pages 50-75 are misnumbered as pages 52-77, and pages 76-133 are misnumbered as pages 75-132.
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Behavioral, Neurochemical, and Histological Characterization of Mice Deficient for Parkin, DJ-1, and Antioxidant Proteins
… for the major mitochondrial antioxidant protein Mn-superoxide dismutase or Cu/Zn-superoxide dismutase. Previous studies have shown that mice with reduced levels of Cu/Zn-superoxide dismutase or Mn-superoxide dismutase are more sensitive to dopaminergic neurotoxins whereas mice with …
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The Cancer Specific Ubiquitin Ligase MAGE-A3/6-TRIM28 Drives Tumorigenesis by Ubiquitination and Proteasomal Degradation of AMPK
… that MAGE-A3/6 binds and regulates the E3 ubiquitin ligase TRIM28, I investigated its biochemical role in cancer. I used unbiased methods to identify 19 novel substrates of MAGE-A3/6-TRIM28, including the known tumor suppressor AMPK. Ubiquitination of AMPK by MAGE-A3/6-TRIM28 induces its …
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Studies on Cellular Nutrient Responses and Protein Degradation
… to amino acids. Amino-acid abundance promotes protein synthesis and cell growth via activation of the protein kinase mTOR, while amino-acid deprivation promotes protein degradation by autophagy. The heterodimeric G protein coupled receptor (GPCR) T1R1-T1R3 can act as an extracellular sensor for …
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Biochemical Characterization of IpaH E3 Ubiquitin Ligase Effector Proteins and Their Host Substrates
… 3 secretion system (T3SS) to inject effector proteins in the cytoplasm of host cells to manipulate host cells processes. T3SS effectors are able to post translationally modify host proteins to reprogram intracellular signaling pathways, actin dynamics, membrane trafficking, and innate immune …