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Showing 1 to 1 of 1 for “"Ubiquitin-Protein Ligase Complexes"”.
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The RASSF1A Tumor Suppressor Regulates a Cascade of Oncogenic Signals That Are Restrained by G1 Checkpoint Mechanisms
… G1/S progression through modulation of the ubiquitin ligase SCF-BTrCP. Thus, RASSF1A represents a critical line of defense against tumorigenesis as its loss triggers cell arrest; however, loss of RASSF1A also promotes proliferative signaling events, and additional malfunctions in cell cycle …