Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"Ubiquitin-Proteasome Pathway"”.
-
Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention
… OF TUMOR CELL DEATH PROGRAM BY TARGETING THE UBIQUITIN-PROTEASOME PATHWAY: SIGNIFICANCE IN CANCER TREATMENT AND PREVENTION</p> <p>by</p> <p>MICHAEL FREZZA</p> <p>August 2010</p> <p>Advisor: Dr. Q. Ping Dou</p> <p>Major: Cancer Biology</p> <p>Degree: Doctor of Philosophy</p> <p>The …
-
Role of the ubiquitin-proteasome pathway in the inner ear : identification of an E3 ubiquitin ligase for Atoh1
… the amount of protein be decreased. Since the ubiquitin-proteasome pathway regulates catabolism of key regulatory proteins, we assessed its role in the degradation of Atoh1. E3 ubiquitin ligases confer substrate specificity to degradation of proteins by transferring a ubiquitin tag to a …
-
The Role of the Ubiquitin-Proteasome Pathway During Xylem Differentiation in <I>Zinnia elegans</I> Mesophyll Cells and <I>Arabidopsis thaliana</I>
A biochemical characterization of ubiquitin (Ub)-proteasome pathway activity was conducted in <I>Zinnia</I> mesophyll cell cultures to examine potential differences between differentiating cells of tracheary element (TE) cultures and non-differentiating cells of control cultures. The pathway is …
-
Molecular function and regulation of the Bax-associating protein MOAP-1
… protein due to constitutive degradation by the ubiquitin-proteasome system. MOAP-1 is rapidly up-regulated by multiple apoptotic stimuli through inhibition of its poly-ubiquitination process. Elevation of MOAP-1 levels sensitizes cells to apoptotic stimuli, whereas, cells with stable expression …
-
Modulation of Transcription Factor Activity by Mono-Ubiquitin
The Ubiquitin-Proteasome Pathway plays both proteolytic and non-proteolytic roles in the regulation of transcription. We recently reported that the ATPases of the 26S proteasome can destabilize activator-DNA complexes in a non-proteolytic manner that requires direct interactions between the Rpt4 …
-
Mdm2-Mediated Degradation of Sirt6 Phosphorylated By Akt1 Promotes Tumorigenesis and Trastuzumab Resistance In Breast Cancer
… It also regulates various cancer-associated pathways and was recently established as a bonafide tumor suppressor in colon cancer. This suggests that SIRT6 is an attractive target for pharmacological activation in cancer treatment, and hence, identification of potential regulators of SIRT6 …
-
Involvement of mitochondrial transcription factor A (TFAM) in porcine gametogenesis and preimplantation embryo development
… was found to be posttranslationally modified by ubiquitination and relegated to sperm tail principal piece in fully differentiated spermatozoa. These data suggest that mitochondrial transcription factor TFAM is developmentally regulated in porcine gametes and embryos, and may exert a critical …
-
Exploring the link between RAG1 Cellular Distribution and Components of the CRL4DCAF1 E3 Ligase
… of RAG1 is dependenton DCAF1, the CRL4DCAF1 E3 ubiquitin ligase, and the 26S proteasome. RAG1 sequestration in nucleoli and nuclear puncta have been implicated in regulating its activity. RAG1 nucleolar egress and puncta formation are dependent on the same domain as DCAF1 association. We …
-
Understanding Structural And Functional Mechanisms of Emi1 Inhibition of the Anaphase Promoting Complex
… is accomplished largely through two major pathways: in bulk through processes such as autophagy and phagocytosis, or in a targeted manner through the ubiquitin-proteasome pathway. Autophagy utilizes an encompassing body to encapsulate targets and surrounding materials for decomposition in a …
-
Investigation into the mechanisms responsible for muscle atrophy in cancer cachexia
… of this study was to investigate the signalling pathway by which PIF reduces protein synthesis in skeletal muscle and to determine the link, if any, to the ability to induce protein degradation. In murine myotubes PIF induced an increase in expression of the active form of the dsNRA dependent …
-
PROTEASOME REGULATES TRANSCRIPTION AND TRANSLATION IN LONG-TERM SYNAPTIC PLASTICITY
… degradation of regulatory proteins by the ubiquitin-proteasome pathway (UPP). To study the molecular mechanisms of learning and memory, we use the late phase of long-term potentiation (L-LTP) in the murine hippocampus as a cellular model of long-term synaptic plasticity. Our previous work …
-
The Role and Regulation of Cyclin G2 in Human Ovarian Cancer Cells
… unstable, and degraded very quickly by the ubiquitin-proteasome pathway. This study also suggests the calpain-mediated proteolysis is a major factor that contributes to the degradation of cyclin G2. This process is dependent on the presence of the cyclin G2 C-terminal PEST motif, as well as …
-
Fbxw7 Triggers Degradation Of Kmt2d To Favor Growth Of Mature B-Type Malignant Cells
The ubiquitin-proteasome system (UPS) precisely controls the levels of most proteins in a cell. As such, the UPS regulates cellular processes such as proliferation and survival and is dysregulated in a variety of diseases including cancer. Lymphoid malignancies are the fourth most common cancer and …
-
Diacylglycerol lipaseα-dependent endocannabinoid signaling in neural stem cells
… the possibility of a specific degradation pathway being involved. DAGLα has a consensus motif for a putative destruction (d-) box that might target DAGL for ubiquitin-proteasome mediated degradation. No evidence was found to support that the d-box is involved in DAGLα degradation, however …
-
Molecular Studies On The Anti-Tumor Effects Of Metal-Based Complexes: Involvement Of The Ubiquitin-Proteasome And Apoptotic Pathways
<p>The ubiquitin-proteasome pathway is crucial to normal cellular function, and as such, has been extensively investigated as a potential target for cancer therapeutics. Many compounds have been tested for their proteasome inhibitory ability, including various small peptide aldehydes, and, …
-
Metabolism of Alpha-Synuclein by the 20S Proteasome
… that oligomeric forms cause dysfunction of the ubiquitin-proteasome pathway of protein degradation, thereby enhancing an alternative pathway that involves ubiquitin-independent degradation by the 20S core particle of the proteasome. The 20S proteasome is known to degrade proteins with regions of …
-
Regulation of Diacylglycerol Acyltransferase-2 and Triacylglycerol Synthesis by Protein Ubiquitination
… is a short-lived protein and is degraded via the ubiquitin- proteasome pathway. Our objective was to identify the lysine residues that are ubiquitinated and determine the role of ubiquitination in regulating DGAT2 stability and triacylglycerol synthesis. Initial experiments found that a …
-
The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity
… recent studies indicate that proteolysis by the ubiquitin-proteasome pathway (UPP) plays a critical role in long-term synaptic plasticity, and dysregulation of this pathway is associated with cognitive impairments in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s …
-
Characterising the mechanism of DCUN1D1 activity in prostate cancer and identifying DCUN1D1 inhibitors for prostate cancer treatment
DCUN1D1 is an E3 ligase of the neddylation pathway. It mediates the posttranslational modification of majority of the cullin family of proteins with NEDD8. This activity is known to enhance ubiquitination of the cullin RING E3 ligases, however, the extent of the impact of DCUN1D1's activity is …
-
Characterising the mechanism of DCUN1D1 activity in prostate cancer and identifying DCUN1D1 inhibitors for prostate cancer treatment
DCUN1D1 is an E3 ligase of the neddylation pathway. It mediates the posttranslational modification of majority of the cullin family of proteins with NEDD8. This activity is known to enhance ubiquitination of the cullin RING E3 ligases, however, the extent of the impact of DCUN1D1's activity is …
Page 1 of 2