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Showing 1 to 8 of 8 for “"Ubiquitin-Conjugating Enzymes"”.
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Mechanistic Studies of the Activation of Ubiquitin-Conjugating Enzymes by Ring-Type Ubiquitin Ligases
Ubiquitination, modification with ubiquitin, is a post-translational regulation of proteins in eukaryotes. Ubiquitin-activating enzymes (E1) activate ubiquitin and form thioester linkages with ubiquitin, which are then transferred onto ubiquitin-conjugating enzymes (E2). Ubiquitin-conjugating …
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A phylogenetic study of ubiquitin conjugating enzymes and structural analysis of human UBE2J proteins
The ubiquitin proteasome system (UPS) is responsible for the degradation and turnover of proteins in eukaryotes. As such it is a key process that is involved in normal and in some cases, abnormal cellular functions. Ubiquitin conjugating enzymes (UBCs) are key components of the UPS and may serve as …
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Ein Gen für ein neues Ubiquitin-konjugierendes Enzym: Genomische Organisation, Expression und Funktion
… Homologien zu Mitgliedern der Genfamilie der 'ubiquitin conjugating enzymes' (E2-Enzyme) aufweist. Diese E2-Enzyme sind in den Ubiquitin-abhängigen Proteinabbau von regulatorischen und abnormalen Proteinen involviert. Sie zeichnen sich durch eine sogenannte UBC-Domäne aus, eine konservierte …
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Regulation of Protein Degradation by ADP-Ribosylation
… is essential for cellular homeostasis. The Ubiquitin-Proteasome System (UPS) is responsible for the regulated breakdown of intracellular proteins. All proteins are not degraded at the same rate in the cell. For instance, global protein turnover rates in mammals change with an average time …
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Investigating the ubiquitin conjugating machinery in *Plasmodium falciparum*
… novel targets against malaria are required. The ubiquitin-proteasome system (UPS), which involves the attachment of the small protein ubiquitin to target proteins, is essential to all eukaryotes and represents a promising target for antimalarial therapies. However, the components of this system …
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The regulation of TGFβ/BMP signalling by deubiquitylating enzymes
… to control TGFß/BMP signalling. Several E3 ubiquitin ligases have been reported to regulate the turnover and activity of TGFß/BMP receptors and R-SMADs, however little is known about their cognate deubiquitylating enzymes (DUBs). A proteomic screen identified the DUBs OTUB1 and USP15 as …
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Ubiquitin Conjugase UBE2K Is Essential for Normal Rat Development and Spermatogenesis
… rat body growth and reproduction. UBE2K is an ubiquitin ligase, and knocking its gene (Ube2k) out in rats resulted in stunted growth, compromised motor capacity of hind legs and infertility. I found infertility in male UBE2K-deficient rats to be caused by an arrest during meiosis-I that …
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Key Role of Lys63-Linked Polyubiquitination in Viral Activation of IRF3
… procedures, Ubc5 was identified as a specific ubiquitin-conjugating enzyme (E2) involved in IRF3 activation. Taking advantages of inducible-RNAi strategy, catalytically active Ubc5 was shown to be essential for viral activation of IRF3. Furthermore, evidences were obtained indicating that …