Global ETD Search
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Showing 1 to 11 of 11 for “"Ubiquitin Specific Protease"”.
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Interactions and Functions of the Ubiquitin Specific Protease 7 in Human Cells
The ubiquitin-specific protease 7 (USP7) is a deubiquitylating enzyme that regulates many important cellular processes and is highly studied for its contributions to cancer. Our lab has previously discovered a binding pocket in the USP7 N-terminal TRAF domain that mediates interactions with target …
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Identifying Novel Interactions Between Human Ubiquitin-Specific Protease 7 (USP7) and Histone Methylating/Demethylating Proteins
The deubiquitinase, Ubiquitin-Specific Protease 7 (USP7) is an indispensable protein responsible for regulating appropriate turnover of proteins involved in numerous signaling pathways and biological processes including immune response, DNA damage response, DNA replication, epigenetics and cell …
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Identifying Novel Interaction Between CDK8 Kinase Module and The Deubiquitinating Enzyme Ubiquitin Specific Protease 7 (USP7)
Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme that regulates and interacts with various cellular substrates, playing regulatory roles in various pathways such as DNA damage repair and epigenetics. This thesis explores the role of USP7 in regulating components of gene expression …
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Identifying Novel Interaction Between the E3 Ubiquitin Ligase Ring Finger Protein 20 (RNF20) and the Deubiquitinating Enzyme Ubiquitin Specific Protease 7 (USP7)
USP7, which is a ubiquitin-specific protease, is an essential deubiquitinating enzyme involved in a plethora of cellular processes such as epigenetic regulation, DNA damage response and oncogenic processes. In this study, RNF20, which is an E3 ligase, has been identified as a novel substrate for …
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Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling
… this thesis. The first project characterizes the ubiquitin-specific protease UBP41 as a protein which upon overexpression causes apoptosis induction in several mammalian cancer cell lines. The second project investigates a possible involvement of the lysosomal cysteine proteases cathepsin-L and …
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The Role of Arabidopsis thaliana P80 in Inositol Signaling
… lab have also shown that P80 is a part of a deubiquitinating enzyme complex along with WDR20 and Ubiquitin-specific protease called UBP3. Our p80 mutants have a root deficient phenotype under low energy conditions which is normalized by addition of sucrose. p80 mutants show reduced growth and …
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Identification and Optimization of Small Molecule Binders for ALK2, USP5, and DCAF1
… cancers: Activin receptor-like kinase 2 (ALK2), ubiquitin-specific protease 5 (USP5), and DDB1-cullin4 associated factor 1 (DCAF1). For ALK2, a kinase involved in the development of diffuse intrinsic pontine glioma, we report the design, synthesis, and evaluation of a first-in-class set of 5- to …
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The role of USP17 in lysosome trafficking and lysosomal function
Ubiquitination and deubiquitination are the important types of post-translational modifications that are involved in the regulation of most complex cellular processes. USP17, a member of the ubiquitin specific protease (USP) family of deubiquitinases, has been shown to be required for cell cycle …
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Defining the regulatory determinants in substrate catalysis by biochemical, biophysical, and kinetic studies for the development of specific small-molecule inhibitors of ubiquitin specific proteases 7 and 17
Ubiquitination is an important post-translational modification involved in maintaining cellular homeostasis by regulating many delicate cellular processes, including the cell-cycle, membrane protein trafficking, endocytosis and apoptosis. Ubiquitin Specific Proteases (USPs) remove ubiquitin …
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Structural and Functional Characterization of the Endosome-associated Deubiquitinating Enzyme AMSH
… required for transport (ESCRT) machinery is a ubiquitin-dependent molecular mechanism made of up of four individual complexes: ESCRT-0, -I, -II, III, that is necessary for regulating the degradation of cell surface receptors directed towards the lysosome. Not only are the ESCRTs implicated in …
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Analysis of the role of the mineralocorticoid receptor in renal principal cell sodium reabsorption in vivo
… the MRAQP2Cre mice, an inducible principal cell-specific gene inactivation system was established in parallel to induce MR inactivation in adult mice. The large genomic DNA fragment harbouring the AQP2 gene, used for the generation of the constitutive AQP2Cre transgene, was also used to drive the …