Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 129 for “"Ubiquitin Proteasome"”.
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Epigenetic and Ubiquitin-Proteasome Mechanisms of Obesity Development
… a high fat diet dysregulates the activity of the ubiquitin-proteasome system, the master regulator of protein degradation in cells, in the hypothalamus of male rodents. Despite this, whether this can occur in both sexes and directly contributes to abnormal weight gain has not been investigated. …
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PMI 5011 regulates the ubiquitin proteasome system in skeletal muscle
… a process that is primarily regulated by the ubiquitin-proteasome system. Studies have shown that an extensively characterized ethanol extract of Artemisia dracunculus L (Russian Tarragon), termed PMI 5011, enhances insulin signaling in human primary skeletal muscle cells and in a rodent model …
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Design and synthesis of molecular tools for the ubiquitin proteasome system
… 0.5% of the population living with dementia. The ubiquitin proteasome system (UPS), in particular the interaction between a mutant form of ubiquitin, Ubb+1, and the E2-conjugating enzyme E2-25K, has been identified as playing a possible pathophysiological role in the early and late stage …
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The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity
… recent studies indicate that proteolysis by the ubiquitin-proteasome pathway (UPP) plays a critical role in long-term synaptic plasticity, and dysregulation of this pathway is associated with cognitive impairments in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s …
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Age related memory loss and the role of the ubiquitin proteasome system
… as the accumulation of damaged proteins. The ubiquitin-proteasome system (UPS), responsible for breaking down damaged proteins, exhibits dysfunction in neurodegenerative disorders like Alzheimer's disease or dementia. While we acknowledge that proteasome function declines with age, its …
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An investigation into the role of the ubiquitin-proteasome system in plant defence
Ubiquitin is a highly conserved regulatory protein that is ubiquitously expressed in eukaryotes. The ubiquitin pathway appears to be more diversified in plants compared to the other organisms. In plants, the ubiquitin-26S proteasome pathway appears to be particularly involved in regulating plant …
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Non-proteolytic roles of the ubiquitin-proteasome system in memory formation across the lifespan
… Epigenetic modifications, such as histone monoubiquitination and ubiquitin signaling, have emerged as key players in these processes. While monoubiquitination of histone H2B is a well-established regulator of increased gene transcription in memory formation, the role of histone H2A …
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Sex-differences in proteasome-independent roles of the ubiquitin proteasome system in memory formation
… in protein degradation during fear memory is the ubiquitin-proteasome system (UPS), which utilizes the small protein ubiquitin to label proteins. Ubiquitin contains eight linkage sites that each lead to a unique outcome for the protein being labeled and a protein can gain one (monoubiquitination) …
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Investigating new roles of the ubiquitin proteasome system in cell death and innate immune signalling
… we explored the role of some regulators of the ubiquitination and proteasome systems in cell death and innate immune signalling pathways in macrophages. Initial studies focused on a form of regulated cell death termed necroptosis, a type of cell death mediated by the receptor-interacting protein …
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The Role of the Ubiquitin-Proteasome System in the Regulation of Nuclear Hormone Receptor-Dependent Transcription
… rekrutieren NHRs auch Komponenten des Ubiquitin-Proteasom-Systems an die Zielgene. Das Ubiquitin-Proteasom-System (UPS) ist das wichtigste intrazelluläre Proteinabbausystem und ist Ziel in der Krebstherapie (Bortezomib). Verschiedene Indizien sprechen für eine wesentliche Rolle des UPS …
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Mechanisms of Controlled Proteolysis during Drosophila Spermatogenesis: Coordinate Action of Apoptotic Caspases and the Ubiquitin-Proteasome System
… We also isolated two members of a Cullin-3-based ubiquitin ligase complex, Cullin-3T and KLHL10. The mutations in cullin-3 were in a specialized intron that splices into a testis-specific isoform, the first characterization of a tissue-specific isoform of this gene. It was the first report …
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Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention
… OF TUMOR CELL DEATH PROGRAM BY TARGETING THE UBIQUITIN-PROTEASOME PATHWAY: SIGNIFICANCE IN CANCER TREATMENT AND PREVENTION</p> <p>by</p> <p>MICHAEL FREZZA</p> <p>August 2010</p> <p>Advisor: Dr. Q. Ping Dou</p> <p>Major: Cancer Biology</p> <p>Degree: Doctor of Philosophy</p> <p>The …
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Components of the Ubiquitin Proteasome System are Required for the Nonapoptotic Death of the C. Elegans Linker Cell
… Our work suggests that components of the ubiquitin proteasome system (UPS) act to promote linker cell death. We show that LET-70, an E2 ubiquitin-conjugating enzyme, is required cell-autonomously for linker cell death. LET-70 levels, as well as those of ubiquitin and some proteasome …
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Role of the ubiquitin-proteasome pathway in the inner ear : identification of an E3 ubiquitin ligase for Atoh1
… the amount of protein be decreased. Since the ubiquitin-proteasome pathway regulates catabolism of key regulatory proteins, we assessed its role in the degradation of Atoh1. E3 ubiquitin ligases confer substrate specificity to degradation of proteins by transferring a ubiquitin tag to a …
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Molecular Studies On The Anti-Tumor Effects Of Metal-Based Complexes: Involvement Of The Ubiquitin-Proteasome And Apoptotic Pathways
<p>The ubiquitin-proteasome pathway is crucial to normal cellular function, and as such, has been extensively investigated as a potential target for cancer therapeutics. Many compounds have been tested for their proteasome inhibitory ability, including various small peptide aldehydes, and, …
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The Role of the Ubiquitin-Proteasome Pathway During Xylem Differentiation in <I>Zinnia elegans</I> Mesophyll Cells and <I>Arabidopsis thaliana</I>
A biochemical characterization of ubiquitin (Ub)-proteasome pathway activity was conducted in <I>Zinnia</I> mesophyll cell cultures to examine potential differences between differentiating cells of tracheary element (TE) cultures and non-differentiating cells of control cultures. The pathway is …
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Molecular function and regulation of the Bax-associating protein MOAP-1
… protein due to constitutive degradation by the ubiquitin-proteasome system. MOAP-1 is rapidly up-regulated by multiple apoptotic stimuli through inhibition of its poly-ubiquitination process. Elevation of MOAP-1 levels sensitizes cells to apoptotic stimuli, whereas, cells with stable expression …
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Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling
… this thesis. The first project characterizes the ubiquitin-specific protease UBP41 as a protein which upon overexpression causes apoptosis induction in several mammalian cancer cell lines. The second project investigates a possible involvement of the lysosomal cysteine proteases cathepsin-L and …
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Persistent “hijacking” of brain proteasomes in HIV-associated dementia
… HIV-associated dementia. Findings of increased ubiquitin-stained deposits and high molecular weight ubiquitin-protein conjugates in brains of HIV-positive subjects suggest impaired protein turnover by the ubiquitin-proteasome system analogous to neurodegenerative disorders such as Alzheimer’s …
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