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Showing 1 to 20 of 31 for “"Ubiquitin E3 ligase"”.

  1. Ubiquitin E3 ligase mediated regulation of HMG-CoA Reductase

    Menzies, SamUniversity of Cambridge2018

    … of HMGCR with Insig proteins, which recruit E3 ubiquitin ligase complexes to mediate degradation of HMGCR by the ubiquitin proteasome system. However, the identity of the E3 ligase(s) responsible for HMGCR ubiquitination is controversial. Here, I use a series of genome-wide CRISPR knockout …

    cambridge Repository record

  2. Artemis Interacts With The Cul4A Ubiquitin E3 Ligase Complex and Regulates The Cell Cycle Progression

    Yan, Yiyi2011

    … cycle regulation as a component of Cullin-based E3 ligase complex. I show that Artemis interacts with Cul4A-DDB1 ligase complex via a direct interaction with the substrate-specific receptor DDB2, and deletion mapping analysis shows that part of the Snm1 domain of Artemis is responsible for this …

    uthsc Repository record

  3. Functional characterization of poly(ADP-ribose) dependent ubiquitin E3 ligase in the DNA damage response

    김, 재진2016

    … overlay assay 20 9. Dot blot 20 10. In vitro ubiquitination assay 20 11. In vivo ubiquitination assay 21 12. Western blot 22 13. Mass spectrometry analysis 22 14. Chromatin immunoprecipitation 22 15. BIOID assay 23 16. Immunofluorescence 24 17. Clonogenic assay 25 18. Protein microarray 25 19. …

    ajou Repository record

  4. Mechanisms of translational control by the ubiquitin E3 ligase neural precursor cell expressed developmentally down-regulated gene 4-like, Nedd4-2

    Lodes, Daphne ElizabethUniversity of Illinois at Urbana-Champaign2022

    Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01

    uiuc Repository record

  5. The identification and characterisation of proteins interacting with SUMO-ubiquitin hybrid chains

    Anderson, OliverUniversity of Dundee2015

    … modification of substrate proteins by either ubiquitin or the small ubiquitin-like modifier, SUMO. In recent years, points of convergence between the once thought distinct and independent SUMO- and ubiquitin-conjugation pathways have been identified. The ubiquitin E3 ligase RNF4 catalyses the …

    dundee Repository record

  6. A study on PIP5Kalpha degradation by Nedd4-1-mediated ubiquitination

    TRAN, HOANG MAI2016

    … PIP5K. Hence, we have examined whether PIP5K is ubiquitinated working as another route for such a regulatory pathway. We found that PIP5Kα, an isoform of PIP5K, interacts with Nedd4-1, a HECT domain-containing ubiquitin E3 ligase, and undergoes proteasomal degradation via Nedd4-1-mediated …

    ajou Repository record

  7. Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)

    Wottawa, Marieke Claudia2012

    … normoxische Degradation von ATF-4 durch das Ubiquitin-Proteasom-System vermittelt wird. Bezüglich der ATF-4 Degradation durch das Ubiquitin-Proteasom-System wurde die Beteiligung der Ubiquitin-E3-Ligase beta-Transductin repeat containing protein (ß TRCP) nachgewiesen. Allerdings konnte mit …

    goettingen Repository record

  8. Defining the mechanism of arsenic-induced degradation of PML

    Hands, Katherine J.University of Dundee2012

    … modification of PML and with the small ubiquitin like modifier (SUMO). SUMO modification of PML recruits the SUMO targeted ubiquitin E3 ligase RNF4 via four SUMO interaction motifs within the N-terminal region of RNF4. PML is then ubiquitylated and targeted for proteasomal degradation. …

    dundee Repository record

  9. Investigating the Role of Pellin03 in TNF Signalling

    Wang, BingweiNational University of Ireland Maynooth2011

    … we observed that knockdown or knockout of the ubiquitin E3 ligase, Pellino3, sensitizes cells to TNF-induced apoptosis. Suppressed expression of Pellino3 leads to the activation of NF-κB, thereby inducing the expression of a series of antiapoptotic proteins, indicating that the increased …

    maynooth Repository record

  10. The study of Murine double minute-2 (Mdm2) in regulating neuronal activity-dependent protein translation

    Liu, Dai-Chi (Debby)University of Illinois at Urbana-Champaign2020

    … function of Murine double minute 2 (Mdm2), an ubiquitin E3 ligase, which is involved in the Gp1 mGluR-mediated translational control and activation leads to the elevation of neural activity. Using a fragile X syndrome (FXS) mouse model, we demonstrated this phenomenon is modulated by …

    uiuc Repository record

  11. Sumo and Ubiquitin Ligases Regulate Hepatocyte Nuclear Factor - 1 Beta Transcriptional Activity

    McNally, Brian Timothy2010

    … proteins that interact with HNF-1β The SUMO E2 ligase, Ubc9, SUMO E3 ligases, PIAS1 and PIASgamma , and the ubiquitin E3 ligase, Arkadia, were isolated as putative interacting proteins. SUMOylation of transcription factors affects their subcellular localization, intracellular transport, …

    utswmed Repository record

  12. The Multifunctional Kinase Bub1 Acts as a Signaling Hub for the Spindle Checkpoint

    Jia, Luying2018

    … to anaphase requires the activation of an ubiquitin E3 ligase, anaphase-promoting complex or cyclosome (APC/C). Cdc20 is the mitosis-specific APC/C activator. The spindle checkpoint prevents premature sister chromatids separation by preventing Cdc20 from activating APC/C. Bub1 is a highly …

    utswmed Repository record

  13. Mechanism of Ubiquitin Induced Activation of RIG-I Like Receptors in Antiviral Innate Immunity

    Jiang, Xiaomo2012

    … signaling protein, MAVS, is not clear. Protein ubiquitination have pivotal roles in diverse cell signaling pathways, including those in the immune system. A ubiquitin E3 ligase, TRIM25, promotes Lysine 63-linked polyubiquitination of RIG-I, and is essential for the RIG-I antiviral pathway. …

    utswmed Repository record

  14. The Role of K63-Linked Ubiquitination Cycles In Akt Kinase Activation

    Yang, Wei-Lei2013

    … Akt membrane translocation is unclear. Protein ubiquitination is a significant posttranslational modification that controls many biological functions such as protein trafficking and signaling activation. Therefore, we hypothesize that ubiquitination may be involved in Akt signaling …

    uthsc Repository record

  15. Brit1/Mcph1 Mediates The Dna Damage Response By Inducing P53 Stability and Promoting Atr Signaling

    Wang, Edward2014

    … dependent on its negative regulator, the MDM2 ubiquitin E3 ligase. Here, we provide evidence that in addition to its role as an upstream regulator of DNA damage response, BRIT1 is able to directly interact with p53 to promote p53 stability. Our results suggest that BRIT1 protects p53 from …

    uthsc Repository record

  16. Establishing the role of RNF4 in the vertebrate DNA damage response

    Chua, Shijia JoyUniversity of Dundee2012

    RNF4 belongs to the family of SUMO-targeted ubiquitin E3 ligases (STUbLs). The role of STUbLs in maintaining genomic stability was first discovered in yeast. The <br/>yeast STUbL mutants displayed genomic instability, elevated mutation rates, sensitivity to DNA damaging agents and also demonstrated …

    dundee Repository record

  17. The Bca2 And Ampk Paradigm: Unraveling The Cancer Connection

    (buac) Ventro, Daniela2013

    … 2 (BCA2/Rabring7/RNF115), a novel RING-finger ubiquitin E3 ligase, is overexpressed in >50% of breast tumors. Herein, I hypothesized that BCA2 is an endogenous inhibitor of AMPK activation in breast cancer cells and that BCA2 inhibition would therefore increase the efficacy of metformin. My …

    wayne-thes Repository record

  18. Mechanisms of TRIM21-directed intracellular degradation

    Rhinesmith, TylerUniversity of Cambridge2023

    … In addition to antibody binding, TRIM21 is a ubiquitin E3 ligase, an enzyme which catalyzes the formation of polymers of the protein ubiquitin around target substrates. When viruses coated in non-neutralizing antibodies escape into the cytosol, TRIM21 binds and decorates the complex with these …

    cambridge Repository record

  19. Characterization of the Genes Essential for Mouse Spermatogenesis

    Wu, Qiuxia2012

    … was reported to directly interact with CUL3 (an ubiquitin E3 ligase), suggesting KLHL10 is involved in the ubiquitination pathway to regulate protein turnover. Using yeast two-hybrid, we screened an adult mouse testis library to identify testicular proteins that can interact with KLHL10 and …

    unr Repository record

  20. PHDS, Stress, And Starvation: The Identification Of A New RPD3 Deacetylase Complex Involved In The Yeast Oxidative Stress And Metabolism Pathways

    Baker, Lindsey A

    … to test whether any yeast PHD fi ngers possess ubiquitin E3 ligase activity, a function ascribed to the PHD-related RING domain. In Chapter 3, I discuss experiments performed to identify the protein interaction partners of Jhd2 and Ecm5,culminating in the discovery that Ecm5 interacts with the …

    rockefeller Repository record

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