Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Ubiquilin"”.
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New Insights Regarding the Intracellular Effects, Trafficking, and Quality Control of the Amyloid Precursor Protein: Implications for Alzheimer’s Disease Pathogenesis
… disease mechanisms. Recently, the gene encoding ubiquilin was shown to be associated with late-onset AD, but the molecular mechanism by which the ubiquilin protein contributes to disease pathogenesis is still unclear. We sought to determine: 1) whether disruption of intracellular calcium …
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Identification of novel target genes for the plasticity-related transcription factor Zif268
… thesis proposes two known proteins, gephyrin and ubiquilin, as well as a novel gene (urma), as potential downstream targets of Zif268. Both gephyrin and ubiquilin are associated with GABAA receptors at inhibitory synapses. Gephyrin is thought to cluster and anchor GABAA receptors at postsynaptic …
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Notch Signaling in Human Neuroblastoma Cells
… this thesis we show that Hash-1 interacts with ubiquilin-1, a protein involved in protecting proteins from degradation. In addition, we show that valproic acid (VPA) induces differentiation of neuroblastoma cells by modulation of the Notch signaling cascade. Aberrant signaling through the EGF …
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The Phase Behavior of Ubqln Proteins and Implications for Protein Quality Control
… our lab discovered that the shuttle protein Ubiquilin-2 (UBQLN2) is recruited to stress granules in cells and undergoes liquid-liquid phase separation (LLPS) in vitro. LLPS is a biophysical process by which proteins separate themselves from the surrounding aqueous solution by forming …
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Characterizing Multivalent Interactions Between Folded Protein Domains and Intrinsically Disordered Regions or Peptide Substrates
… the liquid-liquid phase separation (LLPS) of ubiquilin-2 (UBQLN2). UBQLN2 is a shuttle protein for the proteasome that functions by binding to proteasomal receptors and ubiquitinated substrates via its N-terminal ubiquitin-like (UBL) and C-terminal ubiquitin associated (UBA) domains, …