Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Ube2W"”.
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Mechanisms of TRIM21-directed intracellular degradation
… action of ubiquitin E2 conjugating enzymes UBE2W and UBE2N, which cooperated with TRIM21 to catalyze the formation of a specific type of linear polyubiquitin chain linked through lysine 63 on ubiquitin. This was thought to lead to the recruitment of the segregase p97/VCP and the 26S …
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Structural Insights into TRIM21 Ubiquitination Mechanisms
… suggested that TRIM21 requires the E2 enzymes Ube2W and Ube2N/Ube2V2 to build K63-linked ubiquitin chains and drive anti-viral function. My work reveals how TRIM21 facilitates ubiquitin transfer and differentiates Ube2N from other closely related enzymes. A tri-ionic motif allows TRIM21 to wrap …
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TRIM21 Mediated Antibody-Dependent Intracellular Immunity
… is known to functionally require the E2 enzyme Ube2W, which monoubiquitinates TRIM21 in vitro, and Ube2N, which extends monoubiquitinated TRIM21 to form anchored K63-linked chains. These ubiquitin chains are thought to drive proteasome recruitment and pro-inflammatory NF-B signalling. Using a …