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Showing 1 to 4 of 4 for “"Ube2S"”.
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Enhanced protein degradation by branched ubiquitin chains
… require the ubiquitin-conjugating enzyme E2 S (Ube2S) for degradation, e.g. the Never in mitosis A-related kinase 2 (Nek2A). The reconstitution of Nek2A ubiquitylation revealed that Ube2S does not simply extend a conjugate, but instead branches multiple lysine11-linked chains off the ubiquitin …
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Investigating the role of protein ubiquitylation in the maintenance of genome stability
… I identify the E2 ubiquitin conjugating enzyme UBE2S as a novel factor required for olaparib resistance, and confirm its direct involvement in DNA repair by showing that it rapidly accumulates at sites of DNA damage. This work highlights UBE2S as a potentially useful new biomarker for treatment …
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Understanding Structural And Functional Mechanisms of Emi1 Inhibition of the Anaphase Promoting Complex
… similar to the other APC/C- specific E2 enzyme, Ube2s. Emi1 competes directly with Ube2s for APC/C recruitment, and it is through the combination of these three mechanisms that are afforded by many motifs within Emi1, that makes Emi1 a potent APC/C inhibitor. When associated with Emi1, the APC/C …
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Phopsphorylation and Ubiquitin Modification At Dna Damage Sites In Response to Double-Strand Breaks
… DNA damage sites in an ATM-dependent manner by Ube2S/Ube2C E2 conjugating and RNF8 E3 ligase enzymes and deubiquitinated by OTUD7B (Cezanne) enzyme. I further showed that histones H2A and H2A.X is modified with Lys11-linked polyubiquitination in a DNA damage-dependent manner that is essential …