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Showing 1 to 3 of 3 for “"Uap1"”.
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Investigating the role of UDP-<i>N</i>-acetylhexosamine pyrophosphorylases in regulating <i>O</i>-GlcNAcylation in human disease
… by UDP-N-acetylhexosamine pyrophosphorylase (UAP1). Therefore, I considered whether <i>UAP1</i> gene mutations would phenocopy OGT-CDG mutations. A de novo heterozygous mutation of UAP1 (NM_001324114:c.G685A:p.A229T, DDD entry: …
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Functional Analysis of the F-box protein Fbxl17
… proteins. Among the 37 binding partners Uap1, an enzyme involved in O-GlcNAcylation of proteins was identified most frequently. We demonstrate that Fbxl17 binds to UAP1 directly and inhibits its phosphorylation, which we propose regulates UAP1 activity. Knockdown of Fbxl17 expression …
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Targeting final steps of sugar nucleotide biosynthetic pathway against <i>Aspergillus fumigatus</i>
… from GlcNAc-1P by UDPGlcNAc pyrophosphorylase (UAP1). GlcNAc-1-P is synthesized from GlcNAc-6-P by Phospho N-acetylglucosamine mutase (AGM1). Therefore, targeting AGM1 and/or UAP1 may affect UDP-GlcNAc biosynthesis and in turn elicit antifungal activity. Similarly, UDP-Glc is synthesized from …