Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"UV-induced DNA damage"”.
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Protective Effects of Milk Phospholipids Against UV-Induced DNA Damage in Human Skin Cells
… cancer are caused by exposure to ultraviolet (UV) radiation from the sun. Some of the most common sunscreen ingredients are unstable and can form harmful radicals upon exposure to UV radiation. There is a strong clinical need for a more stable and effective sunscreen ingredient such as bovine …
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The Use of Sphingomyelin to Protect Against UV Induced DNA Damage in Human Keratinocytes
… serious condition caused by chronic ultraviolet (UV) exposure that leads to DNA damage in skin. UV radiation has the potential to lead to DNA damage, which triggers biochemical pathways within a cell. The result is that the cell either undergoes cell cycle arrest, giving the cell time to repair …
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The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway.
… mechanism by which TBX2 is upregulated by the UV-induced DNA damage pathway in melanoma cells and (3) to verify whether TBX2 is a suitable drug target by assessing the cellular sensitivity of control and TBX2-depleted cells in response to the chemotherapeutic drug cisplatin.
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Jednoduchý elektrochemický DNA biosenzor pro detekci poškození DNA způsobeného UV zářením
Ultraviolet (UV) radiation is a common DNA damaging agent. Major DNA lesions, such as cyclobutane pyrimidine dimers (CPDs) and pyrimidine-(6-4)-pyrimidone (6-4PPs) photoproducts, are carcinogenic and mutagenic. UV induced DNA damage was investigated using a simple electrochemical DNA biosensor …
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Disconnecting a Role for DNA Repair in the Pathogenicity of the Human pathogen Cryptococcus neoformans
… research. Considering the evidence of a role of DNA repair in pathogenesis, I investigated DNA repair strategies adopted by Cryptococcus to survive in the environment and to cause successful infection. The repair of UV induced DNA damage was studied for two genes: UVE1 and RAD23, parts of base …
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The role of the histone variant H3.3 and its chaperones in the response to DNA damage
… the response to and repair of various types of DNA damage. Furthermore, a supply of H3.3 has been shown to be required to maintain replication fork progression in the transformed avian cell line DT40, despite the availability during replication of canonical H3. In this thesis, I have examined …
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Role of DNA repair protein ERCC1 in skin cancer
… one of the major repair systems for removal of DNA lesions. The NER pathway has evolved mainly to repair UV-induced DNA damage and is also active against a broad range of endogenously generated oxidative lesions. Defects in NER result in the human inherited disorder xeroderma pigmentosum (XP), …
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Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
… chronic exposure to ultraviolet irradiation (UV). UV-induced DNA damage activates cell cycle checkpoints through a mechanism involving degradation of the cyclin dependent kinase activators, the cell division cycle 25 (CDC25) phosphatases, and also activates Erbb family members indirectly …
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Integration of the phosphorylation-dependent signaling in the DNA damage response network : implications for cancer
The cellular response to DNA damage is an evolutionarily conserved process mediated by Ser/Thr kinases that results in the formation of multiple protein-protein complexes designed to control the cell cycle. The assembly of those multi-protein complexes is often triggered by the phosphorylation of a …
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Regulation of DNA damage tolerance : studies of the translesion synthesis DNA ploymerase eta in Saccharomyces cerevisiae
All organisms must control the effects of DNA damage to protect the integrity of their genomes. In addition to DNA repair, this requires DNA damage tolerance pathways, which allow the continuation of essential processes in the presence of DNA damage. One such mechanism is translesion synthesis …
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New Insights into the Roles of Human DNA Damage Checkpoint Protein ATR in the Regulation of Nucleotide Excision Repair and DNA Damage-Induced Cell Death
… threatened by endogenous and exogenous DNA damaging reagents that may lead to genome instability and cancer. Cells have evolved multiple mechanisms to repair DNA damage or to eliminate the damaged cells beyond repair and to prevent diverse diseases. Among these are ataxia telangiectasia …
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The Role of CDC25A in Ultraviolet-induced Nonmelanoma Skin Tumorigenesis
… Activation of cell cycle checkpoints following DNA damage can result in degradation of CDC25A, leading to cell cycle arrest. Consistent with its role in cell cycle regulation, CDC25A is over-expressed in multiple types of human cancer. Ultraviolet (UV) irradiation, which causes most skin cancer, …
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Understanding the biological processes underpinning neurodegeneration in Xeroderma Pigmentosum
… coupled repair (TC-NER), which rapidly repairs DNA damage on the transcribed strand of actively transcribed regions of DNA. Global genome NER (GG-NER) is a slower process that repairs DNA damage on non-transcribed strands. Patients with defective NER are unable to repair Ultraviolet (UV) induced …