Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"UV-induced"”.
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Fructose 1,6-diphosphate ameliorates UV-induced skin inflammation
… 최근 human keratinocyte cell line (HaCaT)에서 FDP가 UVB 유도 세포내 H2O2 및 prostaglandin 생성을 유의적으로 억제한다고 보고된 바 있다. 본 연구에서는 FDP가 자외선에 의해 유도되는 염증반응 및 산화적 스트레스를 억제할 수 있는지를 피부세포배양 모델과 in vivo 동물시험을 통해 검토하고자 하였다. FDP는 HaCaT keratinocyte에서 UVB에 의해 유도되는 세포사를 억제하였으며, COX-2의 발현 및 MMP-2,9의 활성을 억제하였다. 또한 …
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Microrna Functions In Uv-Induced Cutaneous Squamous Cell Carcinoma
… most common skin cancer, for which long term UV exposure and chronic wounding are the dominant risk factors. Despite these clinically established connections, little is understood about the early molecular response of human skin to UV exposure and its connection to acute wounding and cuSCC. …
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UV Induced Processes in Biomolecules, Hydrated Clusters and Stark Deflected Beams
The nanoscale processes by which UV irradiation initiates damage in biological material have not yet been fully elucidated. This represents a barrier to innovations in radiotherapy and also limits our understanding of the molecular origins of life. Experiments on gas-phase biological building …
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Protective Effects of Milk Phospholipids Against UV-Induced DNA Damage in Human Skin Cells
… cancer are caused by exposure to ultraviolet (UV) radiation from the sun. Some of the most common sunscreen ingredients are unstable and can form harmful radicals upon exposure to UV radiation. There is a strong clinical need for a more stable and effective sunscreen ingredient such as bovine …
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The Use of Sphingomyelin to Protect Against UV Induced DNA Damage in Human Keratinocytes
… serious condition caused by chronic ultraviolet (UV) exposure that leads to DNA damage in skin. UV radiation has the potential to lead to DNA damage, which triggers biochemical pathways within a cell. The result is that the cell either undergoes cell cycle arrest, giving the cell time to repair …
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The Tumor Suppressor PKCδ Is Critical for UV-Induced G2/M Checkpoint Activation and Apoptosis
… Following DNA damage, such as exposure to UV radiation, PKCδ is cleaved in a caspase-dependent manner, generating a constitutively active catalytic fragment (PKCδ-cat) which is necessary and sufficient for keratinocyte (KC) apoptosis. We found that in addition to inducing apoptosis, …
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Photosensitivity and Photodarkening of UV-induced Phosphate Glass Fiber Bragg Gratings and Application in Short Fiber Lasers
… glass fibers prevents the integration of UV-written intra-core fiber Bragg gratings (FBGs) into the fiber laser cavity. The research presented in this thesis is focused on the investigation of photosensitivity of UV-written Bragg gratings in phosphate glass fibers and their application in …
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UV-Induced Intrinsic Fabry-Perot Interferometric Fiber Sensors and Their Multiplexing for Quasi-Distributed Temperature and Strain Sensing
… sensing that can multiplex a large number of UV-induced sensors along a single fiber. The objective of this research is to develop a quasi-distributed sensing technology that will greatly increase the multiplexing capacity of a sensor network and can measure temperature and strain with a high …
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Studies on Potential of Resistance Development By Monilinia Fructicola to Selected Fungicides and Isolation of Uv Induced Cga 64251 Resistant Colonies
UV irradiated conidia of Monilinia fructicola were screened for resistance to 5 μg/ml benomyl, 20 μg/ml vinclozolin, 60 μg/ml captan, 4 μg/ml CGA 64251 and 24 μg/ml fenapronil. No isolates resistant to benomyl, vinclozolin, captan or fenapronil were found. From about 1.2 x 10⁶ conidia 137 colonies …
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The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway.
… mechanism by which TBX2 is upregulated by the UV-induced DNA damage pathway in melanoma cells and (3) to verify whether TBX2 is a suitable drug target by assessing the cellular sensitivity of control and TBX2-depleted cells in response to the chemotherapeutic drug cisplatin.
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The protective effects of the antioxidant combination of ferulic acid with vitamins C and E against UV-induced photodamage in human skin cells
… with vitamins C and E, to reduce the effect of UVA-induced photodamage in human epidermal (HaCaTs) and dermal skin cells (primary human fibroblasts (HFbs) and murine 3T3 cells). Pretreatment with the FA and vitamins C and E (vEC) combination solution reduced UVAinduced ROS in human fibroblasts …
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The Role of Erbb2 in Ultraviolet-Induced Nonmelanoma Skin Carcinogenesis
… increasing. Most of these cancers are caused by UV, which has many effects on the skin. The RTK Erbb2 is activated by UV and is overexpressed in some skin cancer. Targeted Erbb2 overexpression in a mouse model leads to spontaneous skin tumor development [82, 86, 87], However, the role of Erbb2 in …
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Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
… and proliferation in response to ultraviolet (UV) irradiation, resulting in increased skin tumor growth. The mechanisms of EGFR’s mitogenic effects on keratinocytes were examined using EGFR null keratinocytes and an EGFR inhibitor. Genetic ablation or inhibition of EGFR decreased keratinocyte …
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New Insights into the Roles of Human DNA Damage Checkpoint Protein ATR in the Regulation of Nucleotide Excision Repair and DNA Damage-Induced Cell Death
… pathways by which cells handle ultraviolet C (UV-C)- or other exogenous genotoxin-induced bulky DNA damage. However, it is unclear how these 2 pathways may be coordinated. In this study we show that ATR physically interacts with NER factor xeroderma pigmentosum group A (XPA) where an ATR …
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Disconnecting a Role for DNA Repair in the Pathogenicity of the Human pathogen Cryptococcus neoformans
… and to cause successful infection. The repair of UV induced DNA damage was studied for two genes: UVE1 and RAD23, parts of base excision repair and nucleotide excision repair pathways, respectively. My findings suggest that UVE1 is required to combat UV induced stress. Uve1 is a …
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The role of the histone variant H3.3 and its chaperones in the response to DNA damage
… of H3.3 and its chaperones in the response to UV induced DNA damage in a non-transformed, but immortalised, human cell system, the lymphoblastoid line TK6. Using CRISPR-Cas9 genome editing, I created H3.3, ATRX and HIRA knockout mutants and investigated their response to UV irradiation. h3.3 …
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Jednoduchý elektrochemický DNA biosenzor pro detekci poškození DNA způsobeného UV zářením
Ultraviolet (UV) radiation is a common DNA damaging agent. Major DNA lesions, such as cyclobutane pyrimidine dimers (CPDs) and pyrimidine-(6-4)-pyrimidone (6-4PPs) photoproducts, are carcinogenic and mutagenic. UV induced DNA damage was investigated using a simple electrochemical DNA biosensor …
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Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
… chronic exposure to ultraviolet irradiation (UV). UV-induced DNA damage activates cell cycle checkpoints through a mechanism involving degradation of the cyclin dependent kinase activators, the cell division cycle 25 (CDC25) phosphatases, and also activates Erbb family members indirectly …
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