Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"UV damage"”.
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Identification of Near-Uv Chromophores and Characterization of Cellular Responses to Near-Uv Damage and Oxygen Stress
… effect. DNA is the primary chromophore in the UV-C region of electromagnetic spectrum (100-280nm; also known as Far UV or germicidal-UV), and its interaction with UV-C has been extensively studied. However, DNA has very little absorbance in the UV-A region (315-400nm). The identification of …
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Chromosomal Fragmentation in Escherichia Coli: Its Absence in mutT Mutants and Its Mechanisms in seqA Mutants
… restriction enzymes, sensitivity of lysogens to UV damage, and the toxicity when the gam gene was overexpressed in the cell.
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The Use of Sphingomyelin to Protect Against UV Induced DNA Damage in Human Keratinocytes
… serious condition caused by chronic ultraviolet (UV) exposure that leads to DNA damage in skin. UV radiation has the potential to lead to DNA damage, which triggers biochemical pathways within a cell. The result is that the cell either undergoes cell cycle arrest, giving the cell time to repair …
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Residual restoration of DNA lesions in Deinococcus radiodurans mutants indicate presence of a bypass UV-repair process
The differing UV-susceptibility and UV-damage repair capability of the Deinococcus radiodurans strains and the hypothesis of a bypass repair system have been investigated. The results obtained provide evidence that UV radiation engenders synergistic effects in combination with other stressors like …
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Damage-Induced Inflammation and Nociceptive Hypersensitivity In Drosophila Larvae
Mounting an effective response to tissue damage requires a concerted effort from a number of systems, including both the immune and nervous systems. Immune-responsive blood cells fight infection and clear debris from damaged tissues, and specialized pain receptors become hypersensitive to promote …
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Synergistic Environmental Aging of Glass Reinforced Polymer Composites
… individually or in combination to ultraviolet (UV) radiation, water condensation and elevated temperature for approximately 1000 h. The composites and polymers were monitored for weight changes as a function of time and their surfaces were examined after the tests using optical and scanning …
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Targeting c-Met for therapy
… to confer resistance to apoptosis induced by UV damage or chemotherapeutic drugs. c-Met is thus an attractive target for drug development. This study describes the development of monoclonal antibodies against c-Met as therapeutic molecules in cancer treatment/diagnostics. Antibodies were …
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Cellular and Genetic Bases of Cold Nociception and Nociceptive Sensitization In Drosophila Larvae
… such as in patients suffering from tissue damage (from wound or sunburn), or injury to the peripheral nerves, as in patients with diabetes or undergoing chemotherapy. Our goal is to determine the genetic basis for noxious cold perception and injury-induced nociceptive sensitization using …
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Identification and Analysis of Germination-Active Proteins in Bacillus Spores
… Spores boast extreme resistance to chemical and UV damage among other bactericidal conditions. This is problematic due to the difficulty and economic costs of decontaminating exposure sites. The present work focuses on identifying and characterizing proteins active within spore germination, with …
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Investigating proteins that influence membrane-associated germination processes in Bacillus subtilis spores
… to chemical, et and dry heat, desiccation, and UV damage. For pathogenic spore formers, this poses an issue as spores are resistant to most decontamination methods currently in use. This work focuses on characterizing proteins thought to contribute to spore stability and efficient spore …
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New Insights into the Roles of Human DNA Damage Checkpoint Protein ATR in the Regulation of Nucleotide Excision Repair and DNA Damage-Induced Cell Death
… have evolved multiple mechanisms to repair DNA damage or to eliminate the damaged cells beyond repair and to prevent diverse diseases. Among these are ataxia telangiectasia and Rad3-related (ATR)-mediated DNA damage checkpoint and nucleotide excision repair (NER) that are the major pathways by …
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Y-family DNA polymerase architecture: three structural features control accurate deoxy CTP insertion opposite N2-deoxy-guanine-benzo-a-pyrene
… in the Y-Family, which synthesize passed DNA damage. One class of Y-Family DNAPs includes hDNAP k, EcDNAP IV and SsDbh, which insert accurately opposite N2-dG adducts, including BP-N2-dG formed from benzo[a]pyrene (BP). Another class includes hDNAP h, EcDNAP V and SsDpo4, which insert …
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Selenotrisulfide Derivative Of Alpha-lipoic Acid: Evaluation In A Cell Culture Model For Potential Use As A Topical Antioxidant
… Exogenous sources of oxidative stress, such as UV radiation, are capable of generating reactive oxygen species (ROS). Elevated levels of ROS can lead to covalent modifications of lipids, nucleic acids, and proteins within a cell. This damage has been implicated in the development of cancer and …
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Analyzing a calcium-dependent UV response that results in a global chromatin compaction in mammalian cells
… endogenous and exogenous stresses. Once DNA gets damaged, a series of events follow, starting with recognizing the damage by accessing it, then processing and repairing the damaged DNA, and eventually restoring the lesion area to its pre-damage state. However, the structural change in the global …
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Skin Cancer Knowledge, Beliefs, Self-Efficacy, And Preventative Behaviors Among North Mississippi Landscapers
… most comoutdoor workers, who are at high risk of UV damage which increases the individuals' risk of skin cancer development (Centers for Disease Control and Prevention, 2012). This cross-sectional study determined landscapers' skin cancer knowledge, health beliefs, self-efficacy, and protective …
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Characterization of the DNA repair role of the Saccharomyces cerevisiae NSE1 gene
… required for a normal response to DNA damage. Hypomorphic mutations in these subunits render cells sensitive to DNA damaging agents. Of the non-SMC subunits, Nse1 and Mms21 are of particular interest, because Nse1 contains a RING finger motif characteristic of ubiquitin ligases and …
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PARKIN, BLM AND EXO1: INVOLVEMENT IN POST-NER ACTIVITY IN NON-REPLICATING CELLS
… their integrity, a complex machinery of DNA Damage Repair (DDR) proteins has evolved, together with associated signaling pathways that coordinate repair activity with other metabolic processes. One specialized branch of DDR is Nucleotide Excision Repair (NER), responsible for the detection …
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Evaluating the impact of ultraviolet light on chemical and mechanical properties of human scalp hair through controlled and natural experiments
… from exposure to environmental factors such as UV radiation, have been the focus of some studies. Even though there are a range of environmental variables that could be worthy of consideration, understanding the impact of UV radiation is increasingly important given the inevitability of exposure …
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Contributions of aromatic pairs of human Gamma-D-Crystallin to its folding, stability, aggregation, and interaction with human Alpha B-Crystallin
… [Beta][[gamma]-crystallin family. Ultraviolet (UV) damage to these aromatic residues in [Beta][gamma]-crystallins may contribute to unfolding and aggregation of the proteins, leading to development of cataract. [Alpha]-Crystallins belong to the small heat shock protein (sHsp) family and have …
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