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Showing 1 to 3 of 3 for “"UUO"”.
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Identification of Differentially Expressed Genes in a Rat Unilateral Ureteral Obstruction Model
일측성 요관 폐색(unilateral ureteral obstruction, UUO)은 신부전을 유도하는 동물 모델로 신장질환의 다양한 특징들을 관찰할 수 있다. 본 연구는 UUO 모델에서 신부전에 관여하는 유전자를 규명하고자 Wistar 백서의 좌측 요관을 결찰하여 UUO 모델을 만들고 결찰하지 않은 우측 신장을 대조군인 contralateral unobstructed kidney(CUK)로 하여 24시간 후, 이들 신장에서 나타난 유전자 변화를 annealing control primer(ACP)를 이용한 …
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NLRP3 in Renal Injury and Inflammation
… and fibrosis (unilateral ureteral obstruction, UUO), Nlrp3 expression and inflammasome activation were increased in injured kidneys. Compared to wild-type counterparts, Nlrp3-/-mice undergoing UUO displayed reduced renal injury, fibrosis and inflammatory cytokine levels confirming an important …
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Zur Rolle von C5 und [alpha]5[beta]1-Integrin für die Entstehung von renaler Fibrose und mögliche therapeutische Konsequenzen
… we induced a unilateral ureterobstruction (UUO) in C5 deficient mice and suitable wild type controls (as it is the standard model of tubulo-interstitial fibrosis in the mouse). In addition, C5aR-and alpha5beta1-Integrin antagonists were used in wild type mice next to control animals. On days …