Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"USP7"”.
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Interactions and Functions of the Ubiquitin Specific Protease 7 in Human Cells
The ubiquitin-specific protease 7 (USP7) is a deubiquitylating enzyme that regulates many important cellular processes and is highly studied for its contributions to cancer. Our lab has previously discovered a binding pocket in the USP7 N-terminal TRAF domain that mediates interactions with target …
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Identifying Novel Interaction Between the E3 Ubiquitin Ligase Ring Finger Protein 20 (RNF20) and the Deubiquitinating Enzyme Ubiquitin Specific Protease 7 (USP7)
USP7, which is a ubiquitin-specific protease, is an essential deubiquitinating enzyme involved in a plethora of cellular processes such as epigenetic regulation, DNA damage response and oncogenic processes. In this study, RNF20, which is an E3 ligase, has been identified as a novel substrate for …
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Identifying Novel Interactions Between Human Ubiquitin-Specific Protease 7 (USP7) and Histone Methylating/Demethylating Proteins
… deubiquitinase, Ubiquitin-Specific Protease 7 (USP7) is an indispensable protein responsible for regulating appropriate turnover of proteins involved in numerous signaling pathways and biological processes including immune response, DNA damage response, DNA replication, epigenetics and cell …
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Identifying Novel Interaction Between CDK8 Kinase Module and The Deubiquitinating Enzyme Ubiquitin Specific Protease 7 (USP7)
Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme that regulates and interacts with various cellular substrates, playing regulatory roles in various pathways such as DNA damage repair and epigenetics. This thesis explores the role of USP7 in regulating components of gene expression …
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LNCFOXP3 CONTROLS CELL IDENTITY AND FUNCTION OF HUMAN REGULATORY T CELLS
… lncFOXP3 by mass spectrometry. Analysis revealed USP7, a deubiquitinase known to prevent FOXP3 from proteasome-mediated degradation. By exploiting both primary Treg cells and ectopic expression of lncFOXP3 and FOXP3 in a 293T model system, we found that lncFOXP3 contributes specifically to FOXP3 …
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Characterizing the RanGAP1-RanBP2 complex in mitosis
… Komplexen (Topo II alpha, TACC2, CKAP-5, Plk1, USP7, PIAS1). Die meisten davon konnten entweder in vitro mit rekombinanten Faktoren (TACC2, Plk1) oder als endogene Proteine, die mit mitotischem RanGAP1-RanBP2 Komplex als Quelle der Sumo E3 Ligase-Aktivität assoziiert waren (TopoII alpha, Plk1, …