Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"USP30"”.
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Mitochondrial regulation of CD8+ T cell cytotoxicity
… In this work I analyse CTLs derived from USP30-deficient mice, which have been previously characterised as part of the Infection, Immunity and Immunophenotype Consortium and shown to display altered CTL killing. USP30 is a deubiquitinase localised on the outer mitochondrial membrane and on …
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ERK1/2 signalling and protein ubiquitylation in the control of apoptosis
… therapeutic targets. Recent interest in the DUB USP30 has increased as it has been shown to inhibit parkin-mediated mitophagy, with defective mitophagy being linked to Parkinson’s disease. USP30 has also been suggested to play a role in apoptosis and its depletion was shown to sensitise cells to …
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Screening for genes involved in CD8⁺ T cell cytotoxicity and characterisation of a super-killer
… the TRAPP complex implicated in ciliogenesis and Usp30, involved in mitophagy and pexophagy. A further 4 genes were identified as increasing the lytic capacity of CTL and included: Arpc1b, involved in actin filament branching; Bach2, a transcriptional regulator; Lrrc8d, a component of the …