Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"USP18"”.
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Disentangling bacterial virulence mechanisms: Klebsiella pneumoniae targets post-translational modifications (PTMs) to manipulate innate immunity
… by increased expression of the deISGylase USP18 during infection. Remarkably, as was the case for PP2Ac, Klebsiella’s inhibition of ubiquitin-dependent proteolysis accounted for the elevated levels of USP18. Furthermore, elevated USP18 was also dependent on reduced Cullin1 NEDDylation. …
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Cryptosporidium Uses Its Cspv1 Virus to Activate Host Type I IFN Response and Attenuate IFN-Gamma-Mediated Epithelial Anti-Parasitic Defense
… the type I IFN signaling dependent induction of Usp18 expression, as depletion of Usp18 in intestinal epithelial cells enhances the cellular response to IFN-γ and restores IFN--mediated defense in infected cells. Thus, our findings demonstrate that type I IFN signaling in intestinal epithelial …
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Germline Genetic Modulator of Cancer Metastasis
… repressed metastasis-promoting genes XAF1 and USP18. Mechanistically, the V474I mutation may enhance PCSK9's suppression of LRP1 by increasing its binding affinity. Antibody-mediated therapeutic inhibition of PCSK9 suppressed breast cancer metastasis in a variety of murine, human, …