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Showing 1 to 11 of 11 for “"USA300"”.
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Phagosomal escape, sopravvivenza intracellulare e formazione di varianti di piccole colonie di Staphylococcus aureus USA300 nei macrofagi murini RAW 264.7
… S. aureus e complica l'efficacia della terapia. USA300 è un clone importante di S. aureus resistente alla meticillina (MRSA), un patogeno acquisito in comunità e in ospedale in grado di causare infezioni, ma anche di colonizzare il corpo umano, come membro del microbiota. La carnosina …
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The Effect of Antibiotics on Toxin Gene Expression in PVL-positive Staphylococcus aureus Strains
… belong to the same PVL type variant of CA-MRSA USA300 strain, R variant. From which, two isolates were found to belong to the same CC of USA300, CC8. The remaining 7 isolates were found to belong to H variant. Data presented here showed that the sub-MIC levels of both cell wall inhibitors …
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Evaluating the Co-commensal Lifestyles of Staphylococcus aureus and Staphylococcus epidermidis
… encountered on human skin. The hypervirulent USA300 strain of S. aureus was more competitive in co-culture conditions of acidic pH or 25 µM palmitoleic acid alone, but could not compete with S. epidermidis when these conditions were combined. Conversely, in pure culture, these conditions …
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Movement and Stability of the Staphylococcal Cassette Chromosome mec among Staphylococcus aureus
… donor and recipient strains, primarily of the USA300 lineage. Both bacteriophages 80α and 29 were capable of transducing SCCmec type IV and SCCmec type I to recipient strains of S. aureus. Pulse-field gel electrophoresis and mec-associated dru typing were used to confirm the identity of the …
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Genomic surveillance of methicillin-resistant Staphylococcus aureus at local, regional and national levels
… for two potentially high-risk MRSA lineages (USA300 and ST2371) that are otherwise unmonitored by current surveillance. Screening the genomes of MRSA isolated from 1,465 people identified over a 12-month period demonstrated that 4.2% of cases were positive for MRSA USA300, with multiple …
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Microbial interactions with epithelial surfaces.
… severe pulmonary infections caused by USA300 S. aureus strains by challenging rabbits with live bacteria, or purified superantigen. While conducting these studies, I discovered certain USA300 isolates produce a variant form of TSST-1. I used rabbit TSS models, PCR, Southern blots, and …
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Characterisation of the Type VII secretion system of <i>Staphylococcus aureus</i>
… a transcriptional unit with esaA in strains COL, USA300 and SA113. The eleven genes downstream of esxA were shown to be co-expressed in all strains tested. A transcriptional start site for esaA was identified in the esxA-esaA intergenic region in strain RN6390. It was shown that esxA is expressed …
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Characterization of the Factors Associated with SCCmec Mobility in Staphylococcus Aureus
… on the chromosome. Staphylococcus aureus strain USA300 contains SCCmec type IV and a genomic island containing an arginine deiminase pathway, known as ACME, inserted adjacent to one another in the SCCmec chromosomal attachment site. Each element was site-specifically excised from the chromosome …
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Multi-target drug discovery against Staphylococcus aureus and Trypanosoma brucei infections
… methicillin against the community-acquired MRSA USA300 strain, indicating strong synergism. To further investigate antibacterial agents with novel motifs, I synthesized a series of benzoic acids and phenylphosphonic acids and investigated their effects on the growth of Staphylococcus aureus and …
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Investigating The Functional Relationships Of RND Efflux Pumps In Methicillin Resistant Staphylococcus Aureus
The RND superfamily of efflux pumps plays vital roles in the intrinsic defence mechanisms of bacterial pathogens. The staphylococci have two genes encoding RND transporters; farE, which promotes efflux of antimicrobial fatty acids, and an uncharacterized gene we have named femT. Although RND pumps …
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Staphylococcus spp. from animals intended for human consumption, animalderived food and humans in Spain and Senegal: genetic lineages, antibioresistance and virulence
… of both countries, and the human virulent clone USA300 was identified among Spain isolates. In the chapters three and four, the lineage CC398 was screened for pig-derived food S. aureus isolates on one hand, and among patients’ blood culture S. aureus isolates from Spanish hospitals located in …