Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"UPRmt"”.
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The Role of ATF5 in Mitochondrial Maintenance, Biogenesis and UPRmt Signaling Following Acute Exercise in Skeletal Muscle
… The Mitochondrial Unfolded Protein Response (UPRmt) is a protein quality control mechanism that relieves intraorganellar proteotoxic stress in a manner dependent on activating transcription factor 5 (ATF5) during mitochondrial dysfunction. Protein homeostasis can temporarily be disrupted by …
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The Intersection of Neurodegeneration and Mitochondrial Stress in Caenorhabditis Elegans Models of Parkinson's Disease
… the mitochondrial unfolded protein response (UPRmt). Stressors, such as protein misfolding, trigger ATFS-1 to localize to the nucleus, where it activates the expression of over 400 molecular chaperones, proteases, and other proteins. Using Caenorhabditis elegans PD model in which human α-syn …
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Integrity of the Barrier Epithelium in Drosophila Gut is Mediated by Factors That Regulate Intestinal Stem Cell Activity
… the mitochondrial unfolded protein response (UPRmt), validating proliferation specific regulatory genes, and proposing gut barrier function–specific genes as regulators of commensal bacteria density. The results from this project have shown that intestinal stem cells (ISCs) respond …
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Losing Connection: Developmental Stress and Synaptic Loss in Caenorhabditis elegans
… comparable to C. elegans overexpressing the UPRmt inducing histone demethylase jmjd-3.1. We show that expression of jmjd-3.1 is not necessary for synaptic development but is necessary for protection against stress-related synaptic loss from ROS and combined stress in aging animals. We also …
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Evaluation of drought tolerance in genetically modified Lolium perenne L. and Arabidopsis thaliana
… with a mitochondrial unfolded protein response (UPRmt), and studies in yeast and human cells suggest a role in alternative splicing for Ubl5. This PhD study aimed to characterize the LpUbl5 gene in the context of its potential role in drought tolerance using LpUbl5-overexpressing perennial …
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IMPACT OF DRP1 ACTIVATION, UNFOLDED PROTEIN RESPONSE INDUCTION AND FGF21 LEVELS IN DMD PROGRESSION
… associated with the mitochondrial-specific UPR (UPRmt) and a muscle-specific induction of the stress mitokine FGF21. FGF21 detrimental effects have been reported concerning bone loss in mdx mice however it could also impact fibro-adipogenic progenitors differentiation considering that these cells …