Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 111 for “"UPR"”.
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Study of the Cellular Role of GRP78/BiP mono-ADP-ribosylation in UPR and Cancer
Mono-ADP-ribosylation is a reversible post-translational protein modification that modulates the function of proteins involved in different cellular processes, including signal transduction, protein transport, transcription, cell cycle regulation, DNA (deoxyribonucleic acid) repair and apoptosis. …
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Biochemical and Biophysical Studies of the UPR Kinase PERK and its Interactors in Health and Disease
The unfolded protein response (UPR) is a protective cellular mechanism that restores protein folding homeostasis under conditions of endoplasmic reticulum (ER) stress. The PERK-eIF2α branch of the UPR is activated by the accumulation of misfolded proteins in the ER lumen. PERK, upon activation …
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Unfolded Protein Response (UPR) Signaling in Hepatic Stellate Cells (HSC) as a Key Regulator of Liver Fibrosis
… and initiate the Unfolded Protein Response (UPR). The UPR allows HSCs to adapt to ER stress and restore proteostasis to maintain fibrogenic secretion, while failure to restore proteostasis leads to apoptosis. All three arms of the UPR are activated in fibrogenic HSCs, propagated by ATF6α, …
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TMBIM3/GRINA: un gen regulado por la respuesta a proteínas mal plegadas (UPR) que inhibe la apoptosis mediante la modulación de la homeostasis del calcio
La familia de proteínas TMBIM (del inglés TransMembrane Bax-Inhibitor 1 Motive) es altamente conservada y ha sido pobremente caracterizada. Los genes de la familia TMBIM están presente en mamíferos, insectos, plantas y virus y no presentan homología aparente con los miembros de la familia BCL-2, …
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The unfolded protein response and HLA-B27 misfolding: implications for ankylosing spondylitis
The unfolded protein response (UPR) detects the presence of misfolded proteins in the endoplasmic reticulum (ER) and subsequently relieves ER stress by increasing the folding capacity of the ER. The secretory pathway substrate HLA-B27 is highly associated with the chronic inflammatory disease …
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Targeting mdr1 and endocrine therapy-resistant cancers through estrogen receptor
… cascade, the unfolded protein response (UPR), has documented in various human cancers and diseases. However, the precise roles of UPR signaling in development of hormone-dependent gynecological cancers were unknown. Here we show that the activation of UPR prior to EnR stress, also known …
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Mitochondrial Unfolded Protein Response Regulator Atf5 In Mitochondrial Targeted Therapies In Aml
<p>Mitochondrial unfolded protein response (UPR<sup>mt</sup>) is an adaptive transcriptional response induced by damaged proteins accumulated in mitochondria. UPR<sup>mt</sup> signaling involves induction of mitochondrial specific chaperones and proteases such as HSP60, LonP1 and ClpP, aiding in …
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Stress-signal recognition in the unfolded protein response
The unfolded protein response (UPR) maintains protein folding homeostasis in the endoplasmic reticulum (ER) by adjusting its folding capacity to the load of unfolded proteins in the compartment. This critical feedback mechanism governs the functioning of the secretory pathway, impacting various …
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Altered Responses to Endoplasmic Reticulum Stress In Pancreatic Cancer
… stress activates the unfolded protein response (UPR) to reduce the protein load in the ER. Under conditions of moderate ER stress, the UPR promotes cell cycle arrest which allows time for successful protein load reduction and enables cell survival. However, under conditions of high levels of ER …
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Investigating the role of the Caenorhabditis elegans unfolded protein response in immunity and development
… termed the ER Unfolded Protein Response (UPR), which function to restore ER proteostasis. In metazoans, the UPR is controlled by three signaling pathways, controlled by the ER localized transmembrane sensors IRE-1, PERK/PEK-1, and ATF6/ATF-6. The molecular mechanisms and output of the UPR …
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Modeling The Unfolded Protein Response And Its Connection To Cellular Stress
… of events, termed the Unfolded Protein Response (UPR). Cellular stresses range from hypoxia, nutrient deprivation to external stimulus such as heat or radiation. It is vital to understand the complexities involved in this system, to predict the role of UPR in cancer, diabetes and other diseases …
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Characterization of ARV1-Mediated Sterol Transport in Yeast and Mammalian Systems
… a component of the unfolded protein response (UPR) signaling cascade in yeast. Moreover, 𝘢𝘳𝘷1𝛥 strains exhibited constitutive UPR induction, mediated by the unfolded protein sensor Ire1p. Genetic interaction studies revealed that the 𝘢𝘳𝘷1𝛥 𝘪𝘳𝘦1𝛥 homozygous haploid strain is inviable, suggesting …
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Sexual Harassment at the University of Puerto Rico
… harassment within the University of Puerto Rico (UPR) by integrating cultural discourse and the study of sexual harassment. The study design includes qualitative and quantitative research methods to present a comprehensive picture of sexual harassment at the UPR. The study has several purposes …
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The unfolded protein response regulates hepatocellular injury during the pathogenesis of nonalcoholic steatohepatitis
… pathways such as the Unfolded Protein Response (UPR), an adaptive response to disruptions in endoplasmic reticulum (ER) homeostasis. Because the role of the UPR in the progression of liver disease is not well understood, we established an in vitro model to evaluate the role of the UPR in NASH and …
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Identifying new actions of estrogen receptor targetable with small molecules
… sensor pathway, the unfolded protein response (UPR). In ERα positive cancer cells, BHPI opens the endoplasmic reticulum IP3R calcium channel, triggering efflux of calcium into the cytosol, strongly activating all three arms of the UPR. BHPI activates the PERK arm of the UPR, which leads to …
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Probing the protein homeostasis mechanisms in long-lived naked mole-rats
… namely the unfolded protein response (UPR) in the endoplasmic reticulum (ER) and macroautophagy (autophagy), in the NMR. Using these methodologies, the effects of pharmacologically induced in vitro stress and the effects of disease-related neurotoxic protein species on the UPR and …
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Role of Abberant Proteolysis in the Pathogenesis of APL
… stress and activates unfolded protein response (UPR). Although accumulation of misfolded proteins is known to trigger UPR-induced cytotoxic cell death in several neurodegenerative disorders, APL cells are notably resistant to UPR-induced apoptosis. This project was initiated with the goals to …
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The Unfolded Protein Response Increases Production of Pro-Angiogenic Factors by Tumor Cell Lines
… it will trigger the unfolded protein response (UPR) signal pathway through ER membrane stress sensor proteins including activating transcription factor 6 (ATF6), inositol-requiring 1 (IRE1) and PKR-like ER localized kinase (PERK). The UPR is largely a cytoprotective response and is thought to …
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Human rights law in Tunisia in the post-Arab Spring era
Tunisia was at the heart of the series of uprisings known as the Arab Spring, which resulted in the change of the regime. The people of Tunisia demanded political and social changes for a better economy, democracy, human rights, and equality. Since the uprising in 2011, the changes in law, society …
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Genetic analysis of the neuronal integrated stress response in developmental plasticity and organismal physiology of C. elegans
… pathways-the Unfolded Protein Response (UPR) and translational control mediated by eIF2[alpha] phosphorylation. While the cell-autonomous functions of these stress-responsive mechanisms in maintaining cellular homeostasis have been examined, their organismal effects on remodeling …
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