Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"UPLC"”.
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Biomarker analysis for APRT deficiency diagnosis using UPLC-MS/MS
… of kidney stones in APRT deficiency patients. UPLC-MS/MS method for simultaneous quantification of DHA, adenine and the drugs, allopurinol, oxypurinol and febuxostat in human plasma had been developed. The objective of this study was to perform full validation of the UPLC-MS/MS quantification …
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Mass Spectrometry Based Diagnostics for APRT Deficiency: A Validation of a UPLC-MS/MS Urinary Assay for Absolute Quantification of 2,8-dihydroxyadenine and Adenine
… aðferð til magngreiningar á DHA í þvagi með UPLC-QqQ-MS/MS mælingartæki með því að nýta samsætu efnisins í þekktum styrk sem innri staðal við mælingarnar, þó hefur gilding aðferðarinnar ekki enn verið framkvæmd að fullu. Tilgangur þessa verkefnis var að framkvæma gildingu á nýju ArcticMass …
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Subcellular Fractionation Methods for the Quantification of Endogenous Protein in Human Liver Using Targeted Proteomics
… chromatography-multiple reaction monitoring (UPLC-MRM) is a versatile mass spectrometry method with many applications in drug development. Due to its high selectivity, fast analysis time and high sensitivity, UPLC-MRM is widely used in sample bioanalysis for pharmacokinetics. Recently, …
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Characterization of Microorganisms of Interest to Homeland Security and Public Health Utilizing Liquid Chromatography/Mass Spectrometry
… of ultra performance liquid chromatography (UPLC) to this project to improve the throughput of the method. Given that numerous small molecule applications of UPLC have been published, efforts were made to examine the potential of UPLC to enhance the separation of intact proteins. Beginning …
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Examining the Roles of Membrane Lipids and Secreted Bioactive Lipids on Immune System Cell Function: Studies on Mast Cells and Platelets
… liquid chromatography tandem mass spectrometry (UPLC-MS/MS) methods to address the challenge of quantifying mast cell-secreted bioactive lipids in complex cell cultures as well as understanding the roles that membrane phospholipids play in platelet signaling. With the exception of red blood …
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Skysčių chromatografija–tandeminė masių spektrometrija antibiotikų nustatymui maisto produktuose /
… and/or ultra-performance liquid chromatography (UPLC) techniques coupled with tandem mass spectrometry (MS/MS) were developed for the determination of common antibiotics (chloramphenicol, sulfonamides and nitroimidazoles together with their metabolites) in food products. HPLC/UPLC and MS/MS …
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Measuring Kinetic Performance of Monolithic and Fused-Core Columns Using Packed-Capillary Liquid-, Ultrahigh-Performance- and Supercritical Fluid Chromatography
… column at high-speed separations (using UPLC in 0.67-6.76 mm/s linear velocity range). The kinetic performance parameters (minimal plate height, Hmin; maximal plate number, Nmax; optimal plate number, Nopt and optimal velocity, uopt) found for heptanophenone (C7) in packedcapillary LC …
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A More Efficient Method for Extracting and Analyzing Pesticides in Baby foods
… liquid chromatography-ultraviolet (UPLC/UV). The focus will be on improving the extraction process. Starting with eight pesticides, we will study structural differences in the pesticides via middle-infrared spectroscopy to establish extraction compatibility. Also, relative polarities …
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Synthesis of analogues of nordihydroguaiaretic acid and their oxidative metabolism
… peroxidase. Results are analyzed via HPLC and UPLC-MS. It is found that 1 does not autoxidize at pH 7.4 as NDGA does. Two products are produced during incubation of 1 in rat liver microsomes with UPLC-ESI(-)-MS results giving m/z of 879.2 and 574.18. This is consistent with 1 plus 2 GSH and 1 …
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Third Trimester Plasma Metabolites Associated with Gestational Diabetes: An Ancillary Analysis of the Healthy Beginnings Trial
… in the study. Plasma samples were analyzed using UPLC-MS with metabolomic assays for primary metabolomics, aminomics, and lipidomics. Plasma metabolite comparisons were made between participants who developed GDM (n=27) and individuals without GDM (n=23) through UPLC-MS analysis with metabolomic …
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Applications of metabolomics to study the pathophysiology of adverse pregnancy outcomes
… to quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS). Plasma (Cork) and urine (Cork, Auckland) samples were collected at 20 weeks of gestation from pregnant women participating in the SCreening fOr Pregnancy Endpoints (SCOPE) study, an international study that recruited 5,628 …
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Cultivo tradicional e in vitro de Crotalaria retusa para isolamento, identificação e quantificação de alcaloides pirrolizidínicos
… foram analisados por infravermelho, RMN e UPLC- QTOF-MS. Os dados gerados foram processados no software MassLynx versão 4.1 e tiveram todas as suas fórmulas moleculares possíveis deduzidas a partir da massa exata de cada componente. Os perfis químicos dos extratos foram estabelecidos …
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RILIEVO DI FATTORI XENOBIOTICI, CON PARTICOLARE RIFERIMENTO A NICOTINA E COTININA, IN CAMPIONI ISTOLOGICI APPARTENENTI A FETI E NEONATI DECEDUTI PER CAUSE NATURALI.
… last, all the 151 samples have been subjected to UPLC/MS-MS technique for the relief and dosage of nicotine and cotinine.
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The determination of veterinary antibiotics in live animals and animal products
… This thesis was undertaken to develop a UPLC-MS/MS method for the simultaneous analysis of the aminoglycoside and macrolide antibiotics. This is the first time that a combination method for the two classes of compound was developed. A Waters Acquity/ Premier XE system with a dual ESI/APCI …
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Stability of heroin metabolites and oxycodone in rat hair and liver during decomposition
… liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Oxycodone concentrations in both hair and liver decreased as the interment period and decomposition of the carcasses progressed. 6-Monoacetylmorphine was not detected in any hair samples collected from the exhumed carcasses.
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Advanced systems for the rapid detection of anthelmintic drugs in food
… for purpose when its performance was compared to UPLC-MS/MS analyses of milk from cows treated with benzimidazole products. In bovine liver the LOD (32 μg kg-1) and the CCβ (50 μg kg-1) were determined and the analyte recovery was in the range 77-132%. All non-compliant samples were identified …
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Metabolic Stability And Pharmacokinetics In Lead Optimization Of Potential Anti-Psychostimulant Pharmacotherapies
… sigma receptor antagonist using a validated UPLC/MS method. However due to its poor in vivo and in vitro performance further research was halted. Several analogs were then synthesized by blocking the metabolic soft spots of CM156. We performed a preliminary screening of a series of the high …
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Improving CNS Delivery of Genistein for the Treatment of Sanfilippo Syndrome
… of the formulation was evaluated using the UPLC-MS/MS method we developed and validated for quantification of genistein in mouse brain matrix. Consecutive once a day dosing of nanosuspension resulted in higher distribution of genistein in mouse brain. The heparan sulfate polysaccharide was …
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Phytochemical, biological and toxicity studies of terminalia sericea burch. (Combretaceae)
… liquid chromatography-mass spectrometry (UPLC-MS). A method was developed for the simultaneous determination of sericic acid, resveratrol-3-rutinoside, sericoside and arjungluicoside I in the extracts using UPLC with photodiode array detection (PDA). The method was validated according to …
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