Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"UPEC"”.
-
A Proteomics Approach to Investigate Uropathogenic Escherichia coli
Uropathogenic Escherichia coli (UPEC) is the most commonly known cause of urinary tract infection (UTI). The possession of many virulence factors and global dissemination of multi-drug resistant UPEC strains is posing a critical risk to treatment worldwide. The most virulent UPEC strains have …
-
An Investigation into the utilisation of ethanolamine by uropathogenic E. coli
… for 75% of all cases. Uropathogenic E. coli (UPEC) naturally reside in the gastrointestinal tract (GI tract) and infect the urinary tract via migratory ascension of the urethra. Ethanolamine, an amino alcohol found naturally in phospholipids as phosphatidylethanolamine, can be metabolised by …
-
Isolation and Characterization of Bacteriophages Targeting Uropathogenic E. coli
… infections, caused by uropathogenic E. coli (UPEC). Conventionally, UTI’s are treated with antibiotics, such as sulpha-mathoxazole/trimethoprim and ampicillin. However, a significant proportion of UPEC strains have become resistant to these antibiotics, resulting in a significant burden on the …
-
Conservation Of The Intracellular Bacterial Community Pathogenic Pathway In Urinary Tract Infection
… United States. Uropathogenic Escherichia coli: UPEC) is the predominant etiologic agent of UTI; however, several other uropathogens, including Klebsiella pneumoniae, are also significant causative agents. In a murine cystitis model, UPEC utilize a multistep pathogenic pathway in which they …
-
Molecular Insights into the Uropathogenesis of Enterococcus faecalis and Escherichia coli in the Context of Urinary Catheterization
… uropathogenic <italic>Escherichia coli</italic>: UPEC): the most common causative agent of UTI), and the effects of catheterization on bladder physiology using in vitro and optimized in vivo models. In vitro studies reported here demonstrated that <italic>E. faecalis</italic> produces …
-
The Physiological and Morphological Responses of the Bladder Urothelium to Differential Injury
… from instillation of uropathogenic E. coli: UPEC), a cellular damage model from single dose protamine sulfate: SDPS) instillation, and an inflammatory damage model from multiple instillations of lipopolysaccharide: LPS). We identified that UPEC injury increased the pain response to bladder …
-
Investigating the effect of prophylactic D-mannose treatment on adhesion of Uropathogenic Escherichia coli to the human bladder epithelium
… caused by Uropathogenic Escherichia coli (UPEC). Treatment of UTIs is challenged by the continued increase of antibiotic resistance, and alternative strategies are necessary to reduce this disease burden. The pathology of UTI rapidly develops when microorganisms bind to and invade the …
-
Innate immunity in defence against infection and tissue repair of the urinary tract
… are caused by uropathogenic *Escherichia coli* (UPEC) and are limited to the lower urinary tract (cystitis), but ascending infection (pyelonephritis) can lead to fibrosis and the development of chronic kidney disease. A complex network of tissue-resident immune cells exists throughout the urinary …
-
The Nature of Uropathogenic Escherichia coli ST127
… Analysis was performed to determine if UPEC ST127 had a propensity towards a certain group of individuals, was underrepresented due to diagnostic criterion or possessed a novel polymicrobial aetiology concealing the true prevalence of this clone in the general population. To enable …
-
Role of <i>bax</i>, <i>ibpA</i>, <i>ibpB</i> and <i>cspH</i> Genes in Protecting CFT073 (Uropathogenic <i>Escherichia coli</I>) Against Salt and Urea Stress
Uropathogenic <i>Escherichia coli</i> (UPEC) are the primary cause of 80 to 90% of uncomplicated urinary tract infections. After entering the urinary tract, uropathogenic <i>E.coli</i> has to tolerate high levels of salt and urea in urine to cause a successful infection. The osmotic stress imposed …
-
Genetische und molekularbiologische Analyse von fim Determinanten bei Citrobacter freundii und Escherichia coli
… Virulenzfaktoren von uropathogenen E. coli (UPEC) angesehen. Trotzdem konnte eine Reihe von klinischen UPEC Isolaten identifiziert werden, die diesen Adhäsintyp nicht mehr exprimieren. Genetische Untersuchungen im Rahmen dieser Arbeit ergaben, dass in 11 Isolaten das fimEc Operon vollständig …
-
INVESTIGATION OF ANTIBIOFILM AND ANTIVIRULENCE ACTIVITY OF 5-FLUOROCYTOSINE IN ESCHERICHIA COLI
… virulence factors of uropathogenic E. coli (UPEC) like curli fibers, secreted toxins, type I and P fimbriae, suggesting that the effect of 5-FC can also take place in clinically relevant isolates of E. coli. This result is further supported by the observation of reduction in UPEC cell …
-
Untersuchungen zur Regulation von Shiga-Toxin 2 und zur Attenuierung von enterohämorrhagischen Escherichia coli
… dazu veränderte die Deletion von recA im UPEC-Stamm O6:K15:H31 536 die Virulenz dieses Stammes nicht. Im Rahmen dieser Arbeit erfolgte die Auswertung der Ergebnisse der Virulenztests. Die Deletion von recA ist außerdem eine wichtige Sicherheitsmaßnahme für eine Prävention der Integration …
-
Escherichia Coli ST131 Collected From Companion Animals Can Cause Cystitis and Pyelonephritis in a Murine Model of Urinary Tract Infection
Background: Uropathogenic Escherichia coli (UPEC) cause 80% of uncomplicated urinary tract infections (UTI) globally. Since the mid- 2000s, a subset of UPEC called ST131 have undergone rapid pandemic spread. ST131 are a major cause of UTIs that lead to serious complications in humans like …
-
Molekulargenetische Untersuchungen zur Persistenz und Genomvariabilität von Escherichia-coli-Isolaten von Patientinnen mit chronisch rezidivierenden Harnwegsinfektionen
… überwiegend durch uropathogene Escherichia coli (UPEC) ausgelöst. Die genaue Erforschung der Krankheitserreger durch molekularbiologische Verfahren könnte zur Entwicklung neuer diagnostischer Methoden sowie zu besseren Präventions- und Therapiestrategien führen. In der vorliegenden Studie wurden …
-
Analysis of the genome organization and fitness traits of non-pathogenic Escherichia coli strain Nissle 1917 (O6:K5:H1)
… and for the uropathogenic E. coli O6 strains (UPEC) 536 and CFT073. I. Summary 4 The molecular reason for the semi-rough phenotype and serum sensitivity of strain Nissle 1917 was analyzed. The O6-antigen polymerase-encoding gene wzy was identified, and it was shown that the reason for the …
-
Die Bedeutung der "High-Pathogenicity Island" (HPI) für kommensale und uropathogene Escherichia coli
… E. coli vermuten. Die Siderophorproduktion der UPEC-Stämme U3366 und der U3366 irp1-Rekomplementanten konnte in vitro unter Eisenmangelbedingungen gezeigt werden, wohingegen die Mutante des Syntheseapparates (U3366 irp1) keine Yersiniabaktinproduktion aufwies. Im Harntraktinfektionsmodell der …
-
Toll like Receptor 4-Mediated Immune Responses in the Bladder Epithelium
… we found that BECs continue to fight UPEC even after bacterial invasion by triggering bacterial exocytosis through a distinct TLR4-mediated mechanism following activation by LPS. In addition, we reveal that Caveolin-1, Rab27b, PKA, and MyRIP are components of the exocytic compartment …
-
Phenotypic, Genotypic, and Pathogenic Evaluation of E. coli ST131 Clinical Isolates
… and invasion, and curli production. Twenty UPEC clinical isolates of E. coli ST131 and non-ST131 were used for both in vivo and in vitro studies. Six mice per isolate were inoculated via urethral catheterization. CFUs were determined from bladder and kidneys. In vitro and in vivo …
Page 1 of 2